No abstract available.
Botulinum Toxins, Type A* ; Muscles* ; Nerve Block*

Objective:To investigate the role of shelter hospital in carrying out the medical support.Methods: Analysis to the application of wartime medical rescue, the large scale activities medical rescue security in peacetime, medical support of military exercise, respond to biological terrorist attack and infectious events of public health, natural disaster medical rescue, army emergency force of medical service training and remote and poor area to make a round of visits. Results: As an important part of medical rescue, shelter hospitals have full-featured, highly mobile, rapid assembly and so on.Conclusion: Shelter hospital shows the importance of in carrying out the diversification medical support tasks.

Objective To investigate the effects of combined treatment of suberoylanilide hydroxamic acid(SAHA)and TNF?related apoptosis inducing ligand(TRAIL)on proliferation and morphology change of triple?negative breast cancer cell MDA?MB?231. Methods The effects of combination treatment of SAHA and TRAIL on proliferation and morphology change of MDA?MB?231 cells were monitored by RTCA. Morphology changes of MDA?MB?231 cells by different treatment factors were observed through time?lapse live cell imaging acquisition. Results Real?time cell proliferation assays showed that a synergistic effect were found when MDA?MB?231 cells were treated with combination of SAHA and TRAIL , and reached the best effect with 5μmol/L SAHA and 50 ng/mL TRAIL. The results of time?lapse live cell imaging acquisition showed that the growth inhibition of MDA?MB?231 cells with combined treatment of SAHA and TRAIL were more obvious than that with treatment of SAHA or TRAIL alone. Conclusion The combined treatment of SAHA and TRAIL induces a synergistic effect on growth inhibition in triple?negative breast cancer cell line MDA?MB?231.

Aim To investigate the effects of com-bined treatment of SAHA and TRAIL on human breast cancer ER positive cell line MCF-7 . Methods MCF-7 cells were treated with SAHA and/or TRAIL. The inhibitory rates were detected by real-time cell prolifer-ation assays. Morphology changes of MCF-7 cells were observed through time-lapse live cell imaging acquisi-tion. Results Real-time cell proliferation assays showed that the anti-tumor efficacy of SAHA was sig-nificantly enhanced in combination with TRAIL. The results of time-lapse live cell imaging acquisition dem-onstrated that, with treatment of SAHA and TRAIL, the growth inhibition of MCF-7 cells was more obvious than that of in TRAIL or SAHA treatment alone. Con-clusion The combination treatment of SAHA and TRAIL has a synergistic effect of growth inhibition on breast cancer MCF-7 cells.

OBJECTIVE:To study the adverse drug reactions induced by?-lactam antibiotics and to promote rational use of drugs in clinics.METHODS:442ADR cases induced by?-lactam antibiotics collected in our hospital during2001～2005were analyzed retrospectively.RESULTS:Among the total961ADR cases collected in5years,46%were induced by?-lactam antibiotics.The most common displays of ADR were the lesion of skin and the appendants,followed by the lesion of cardiovas-cular system and digestive system etc.CONCLUSION:It is advisable to promote rational use of?-lactam antibiotics and strengthen ADR monitoring so as to decrease or avoid the occurrence of ADR.

No abstract available.
Societies, Medical*

Primary health care providers play a critical role in maintaining public health, and the appropriate use of pharmaceutical products is one of the major parts of their practice. This series of articles, entitled 'Clinical Pharmacology Review for Primary Health Care Providers,' is intended to help primary health care providers select more appropriate prescriptions for frequently used drugs based on up-to-date information. We expect that this effort will contribute to improvements in public health and diminish unnecessary drug use.
Histamine Antagonists* ; Pharmaceutical Preparations ; Pharmacology ; Pharmacology, Clinical* ; Prescriptions ; Primary Health Care* ; Public Health

No abstract available.
Androgens* ; Bone Density* ; Female ; Humans

Microcirculation includes arteriole, capillary and venule, which occupies more than 90% of whole vessels. It provides molecular exchange between inside and outside of the vessels. In the microcirculatory disturbance, there are change of vascular diameter, decrease in blood flow, oxidative stress, increase in vascular permeability, degranulation of mast cells, and so on. Microcirculatory disturbance is related with not only cardiovascular and cerebral vascular diseases, but also vascular diseases in diabetes mellitus, and liver and renal dysfunction. Traditional Chinese medicine has treated the microcirculatory disturbance by herbal medicines and acupuncture. However, little is known about mechanisms of effects of herbal medicines and acupuncture on the microcirculatory disturbance. The technique of intravital microscopy allows for quantitative investigation of vascular permeability, oxidative stress, and adhesive interaction between different circulation cells and the blood vessel walls.
In Department of Internal Medicine, Keio University, we have investigated the effects of herbal medicines and acupuncture on microcirculatory disturbance through observation of changes in vascular permeability using FITC-labeled albumin, and oxidative stress using DHR fluorescence. In this literature, I show our data and explain the mechanisms of protective effects of herbal medicines and acupuncture on microcirculatory disturbance.