1.A Case of Rickettsia Typhi.
Deuk Hwan JUN ; Sang Joo HAN ; Bae Young KIM ; Won Il PARK ; Kyung Ja LEE
Journal of the Korean Pediatric Society 1989;32(12):1736-1739
No abstract available.
Rickettsia typhi*
;
Rickettsia*
2.Three-Week Dietary Intervention at Workplace Cafeteria - a Pilot Study.
Moo Young KIM ; Mi Jeoung KIM ; Han Deuk PARK ; Shin Sil KIM ; Ji Won LEE
Korean Journal of Health Promotion 2012;12(3):123-128
BACKGROUND: A healthy diet is important for the prevention and management of major chronic diseases including cancer, cardiovascular disease, diabetes, and obesity. However, the effect of dietary intervention-based education and consultation has not been satisfactory. This study sought to investigate the effects of a diet intervention supplying food directly to the workplace cafeteria. METHODS: Study subjects included 36 employees (23 men) staffed at two companies located in Seoul and Gyeonggi-do. Participants were supplied with liquid meals made mainly with fruits and vegetables for breakfast and dinner. Lunch was supplied as well and comprised of a balanced diet. Consumption of other foods, except water and provided snacks, were prohibited. The program also included light exercise, yoga, and mind-body control for 20 minutes, three times a week. Changes in anthropometric and metabolic parameters were evaluated. RESULTS: None of the subjects complained of serious adverse effects or dropped out of the program. Post-intervention mean body weight and body fat mass decreased significantly (-3.3 kg and -2.0 kg respectively, p<0.001 for both comparisons). There were additional reductions in systolic blood pressure (-6.7 mmHg, p<0.001), fasting glucose (-9.0 mg/dL, p<0.001), total cholesterol (-13.9 mg/dL, P=0.005), triglyceride (-44.0 mg/dL, p<0.001), and insulin (-2.4 uIU/mL, P=0.007). The satisfaction rate of the program was 88%. CONCLUSIONS: This study showed that a diet intervention supplying food directly to the workplace cafeteria could succeed in decreasing body weight and improving metabolic parameters, most likely due to high compliance.
Adipose Tissue
;
Blood Pressure
;
Body Weight
;
Breakfast
;
Cardiovascular Diseases
;
Cholesterol
;
Chronic Disease
;
Compliance
;
Diet
;
Fasting
;
Fruit
;
Glucose
;
Insulin
;
Light
;
Lunch
;
Meals
;
Obesity
;
Pilot Projects
;
Snacks
;
Triglycerides
;
Vegetables
;
Yoga
3.Clinical analysis of the acromioclavicular dislocation treated with modified phemister method.
Churl Hong CHUN ; Keun Ho PARK ; Hong Jun HAN ; Deuk Man CHO
The Journal of the Korean Orthopaedic Association 1992;27(4):1052-1059
No abstract available.
Dislocations*
4.Nuclear protein binding patterns in the 5'-upstream regulatory elements of HLA class I genes.
Jeon Han PARK ; Joo Deuk KIM ; Se Jong KIM
Yonsei Medical Journal 1994;35(3):295-307
The expression of MHC class I genes has been thought to be regulated by two major cis-acting regulatory elements. The first region, enhancer A (Enh A) spanning from positions -210 to -165 contains perfect palindrome (PP), TGGGGATTCCCCA. The PP is well-conserved both in mouse and human MHC class I genes, even though the PP is disrupted by 2 bp substitutions (TGAGGATTCTCCA) in HLA-C genes. Three proteins binding to the Enh A of HLA-A and -B locus genes, but very weakly or nearly not to the Enh A of HLA-C locus gene have been identified. To determine functional importance of the PP for binding of trans-acting protein, mutant DNA probes were made by site-directed in vitro mutagenesis and then electrophoretic mobility shift assay was performed. HLA-A mutant DNA probe, in which the PP is disrupted, shows the same nuclear protein binding pattern as that of the HLA-C gene, and HLA-C mutant DNA probe, in which the PP is introduced, shows the same nuclear protein binding pattern as that of the wild type HLA-A gene. These data suggest that the perfect palindrome and its cognate DNA binding nuclear protein play an important role in the HLA class I gene regulation, and thus the lower expression of HLA-C antigen may be ascribed to no or very weak factor binding to the nonpalindromic sequences of HLA-C upstream DNA.
Animal
;
Base Sequence
;
Cell Nucleus/metabolism
;
Enhancer Elements (Genetics)
;
*Genes, MHC Class I
;
Human
;
Mice
;
Molecular Sequence Data
;
Nuclear Proteins/*metabolism
;
Protein Binding
;
*Regulatory Sequences, Nucleic Acid
;
Support, Non-U.S. Gov't
5.Effect of Combined Administration of Acamprosate and Naltrexone on Alcohol Intake in C57BL/6 Mice.
Sung Gon KIM ; Byeung Deuk HAN ; Je Min PARK ; Myung Jung KIM
Journal of Korean Neuropsychiatric Association 2001;40(5):981-990
OBJECTIVES: For the relapse prevention in alcohol dependence, a lot of studies suggested that combined administration of two or more drugs which have different mechanism of action is more effective than each drug alone. In order to investigate the effectiveness of combined administration of naltrexone and acamprosate in comparison with naltrexone alone, this study was carried out by comparing the amount of alcohol intake in C57BL/6 mice co-administered with naltrexone and acamprosate with that in C57BL/6 mice with naltrexone alone. METHODS: In 42 C57BL/6 mice in the state of alcohol dependence, naltrexone 0.025mg/kg or 1.0mg/kg alone or with acamprosate 50mg/kg or 200mg/kg were administrated for ten days. The amounts of alcohol consumption for 2 hour, water consumption for 22 hours, and food intake for 24 hours were measured. RESULTS: 1) A significant reduction of alcohol intake for 2 hours was observed when the mice were treated with naltrexone 0.025mg/kg or 1.0mg/kg and acamprosate 50mg/kg or 200mg/kg simultaneously compared with naltrexone 0.025mg/kg or 1.0mg/kg alone. This effect was significant on the eighth and tenth days of drug administration. 2) Naltrexone administration of 1.0mg/kg was significantly more effective than that of 0.025 mg/kg in reducing alcohol intake from the second day of drug administration up to the tenth day. 3) No significant difference was revealed between the effect of naltrexone alone and that of naltrexone with acamprosate on 22 hour water consumption and 24 hour food intake. CONCLUSION: From these results, it is suggested that the effect of combined treatment with naltrexone and acamprosate is superior to that of naltrexone alone in prevention of relapse in alcohol dependence.
Alcohol Drinking
;
Alcoholism
;
Animals
;
Drinking
;
Eating
;
Mice*
;
Naltrexone*
;
Recurrence
6.Locking of the metacarpophalangeal joint due to volar plate tear.
Jong Deuk RHA ; Yong Hoon KIM ; Suong Il YOON ; Goo Hyun BAEK ; Yong Han PARK ; Duk Ryeon KIM
The Journal of the Korean Orthopaedic Association 1992;27(6):1493-1498
No abstract available.
Metacarpophalangeal Joint*
;
Palmar Plate*
7.The Role of Simple Radiography in the Evaluation of Intraarticular Calcaneal Fracture.
Woo Chun LEE ; Jong Deuk RHA ; Hyun Soo PARK ; Young Kil HAN ; Byeong Chun CHANG ; Kea Hyuak UHM
The Journal of the Korean Orthopaedic Association 1998;33(6):1592-1598
Since CT scanning was introduced in the diagnosis of calcaneal fracture, we became to understand more clearly the pathoanatomy of the injury. However we have to determine if we would or would not take CT scanning by simple radiography in the acute setting and most of the surgeons still use simple radiography in evaluating postoperative result. And also we have to determine the accuracy of reduction and position of screws by simple radiography intraoperatively. The purpose of this report is to determine the accuracy of simple radiography in assessing the pathological anatomy of the intraarticular calcaneal fracture by experimental and clinical studies. This is a combined experimental and clinical studies using four below knee amputation specimens and 15 patients with 19 displaced intraarticular calcaneal fractures treated at Hanil General Hospital between Jan. 1996 and May 1997. The lateral view of the foot was the best radiographic view for visualizing the degree of depression of the posterior facet. With regard to the location of a fracture line, findings of Broden views correlated well with findings on CT in 17 of 19 fractures. With regard to gapping between fragments, the axial view was not satisfactory in the majority of cases(15 of 19 cases). There was no case which showed more than 2 mm of discrepancy between the findings on Broden view and CT. We conclude that we may obtain most of the important informations about the pathological anatomy of the intraarticular calcaneal fracture by simple radiography.
Amputation
;
Depression
;
Diagnosis
;
Foot
;
Hospitals, General
;
Humans
;
Knee
;
Radiography*
;
Tomography, X-Ray Computed
9.K-ras and p53 gene mutation in endometrial hyperplasia and adenocarcinoma.
Hye Ok KIM ; Joo Han LEE ; In Woo LEE ; Sun Aee HAN ; Mee Ja PARK ; Hyun Deuk CHO ; In Sun KIM ; Chul Hwan KIM
Korean Journal of Obstetrics and Gynecology 1999;42(10):2192-2198
Endometrial adenocarcinoma is the third common malignancy of female genital tract and categorized as estrogen-dependent tumor (type I) or not (type II). Type II endometrial adenocarcinoma more frequently occurs in oriental, which may arise from genetic alterations such as K-ras and p53. To identify whether the K-ras and p53 mutational activation are occurred during endometrial carcinogenesis, we examined point mutations of K-ras codon 12, 13, 61 (PCR-RFLP) and p53 exon 5, 6, 7, 8 (PCR-SSCP) in the 19 samples of endometrial adenocarcinoma. The 9 samples of normal endometrium and 24 samples of endometrial hyperplasia were also examined. K-ras codon 12 mutations were found in one of 3 cases of atypical hyperplasia (33.3%) and three of 19 cases of endometrial adenocarcinoma (15.7%). The correlation with K-ras mutation and endometrial hyperplasia/adenocarcinoma was statistically insignificant(p=0.306). p53 mutation was found in only one case of endometrial adenocarcinoma which concomitantly occurred with K-ras mutation. It could not be determined that K-ras mutation was early or late event during endometrial carcinogenesis due to a few cases of atypical hyperplasia and no K-ras mutation in the benign endometrial hyperplasia. The endometrial adenocarcinoma with K-ras mutation was observed in postmenopausal old age groups, and revealed moderate to severe histologic grade, early clinical stage, and negative lymph node metastasis.
Adenocarcinoma*
;
Carcinogenesis
;
Codon
;
Endometrial Hyperplasia*
;
Endometrium
;
Exons
;
Female
;
Genes, p53*
;
Humans
;
Hyperplasia
;
Lymph Nodes
;
Neoplasm Metastasis
;
Point Mutation
10.Electromyographic evaluation of delayed spinal cord injury secondary to high voltage electrical burns.
Jong Deuk RHA ; Yong Hoon KIM ; Seung Il YOON ; Joon Soon KANG ; Goo Hyun BAEK ; Yong Han PARK ; Tai Ryoon HAN ; Hyun Sook KIM
The Journal of the Korean Orthopaedic Association 1992;27(4):1187-1193
No abstract available.
Burns*
;
Spinal Cord Injuries*
;
Spinal Cord*