1.A Case of Mycobacterium chelonae Infection at the Site of Acupuncture.
Byeol HAN ; Min Wha CHOI ; Tae Young HAN ; June Hyunkyung LEE ; Sook Ja SON
Korean Journal of Dermatology 2017;55(10):717-720
No abstract available.
Acupuncture*
;
Mycobacterium chelonae*
;
Mycobacterium*
;
Nontuberculous Mycobacteria
2.A Sporadic Case of Verrucoid Cornifying Darier's Disease.
Byeol HAN ; Tae Young HAN ; June Hyunkyung LEE ; Sook Ja SON
Korean Journal of Dermatology 2016;54(9):755-756
No abstract available.
Darier Disease*
3.A Case of Systemic Sclerosis Manifesting as Digital Finger Ulcers and Leg Ulcers.
Byeol HAN ; Min Wha CHOI ; Sook Ja SON ; June Hyunkyung LEE ; Tae Young HAN
Korean Journal of Dermatology 2018;56(3):218-220
No abstract available.
Fingers*
;
Leg Ulcer*
;
Leg*
;
Scleroderma, Systemic*
;
Ulcer*
4.A Case of Nodular Colloid Degeneration in a 40-year-old Woman.
Byeol HAN ; Won Mi LEE ; Sook Ja SON ; June Hyunkyung LEE ; Tae Young HAN
Korean Journal of Dermatology 2018;56(6):393-395
Colloid degeneration of the skin is a rare, distinct clinicopathological entity characterized by the deposition of colloid material in the dermis. Nodular colloid degeneration (NCD) is a clinical variant of colloid degeneration of the skin. Herein, we report the case of a 40-year-old woman who presented with a 3-year history of multiple asymptomatic yellowish-brown, indurated papules and plaques on her forehead. Histopathologic examination of the lesion revealed deposition of amorphous pale pink homogenous colloid material with irregular clefts, fissures, and scattered pyknotic nuclei in the upper dermis. The material was negative for Congo red staining, and periodic acid-Schiff and Masson's trichrome staining revealed positive reactivity. Scattered fragmented elastic fibers were present in the colloid material on Verhoeff—Van Gieson staining. The patient was diagnosed with NCD. We propose that NCD should be considered in the differential diagnosis of long-standing facial nodules and plaques.
Adult*
;
Colloids*
;
Congo Red
;
Dermis
;
Diagnosis, Differential
;
Elastic Tissue
;
Female
;
Forehead
;
Humans
;
Skin
7.The Effect of Treadmill Exercise on Ischemic Neuronal Injury in the Stroke Animal Model: Potentiation of Cerebral Vascular Integrity.
Kyoung Ah KANG ; Hohyun SEONG ; Han Byeol JIN ; Jongmin PARK ; Jongmin LEE ; Jae Yong JEON ; Youn Jung KIM
Journal of Korean Academy of Nursing 2011;41(2):197-203
PURPOSE: This study was done to identify whether pre-conditioning exercise has neuroprotective effects against cerebral ischemia, through enhance brain microvascular integrity. METHODS: Adult male Sprague-Dawley rats were randomly divided into four groups: 1) Normal (n=10); 2) Exercise (n=10); 3) Middle cerebral artery occlusion (MCAo), n=10); 4) Exercise+MCAo (n=10). Both exercise groups ran on a treadmill at a speed of 15 m/min, 30 min/day for 4 weeks, then, MCAo was performed for 90 min. Brain infarction was measured by Nissl staining. Examination of the remaining neuronal cell after MCAo, and microvascular protein expression on the motor cortex, showed the expression of Neuronal Nuclei (NeuN), Vascular endothelial growth factor (VEGF) & laminin. RESULTS: After 48 hr of MCAo, the infarct volume was significantly reduced in the Ex+MCAo group (15.6+/-2.7%) compared to the MCAo group (44.9+/-3.8%) (p<.05), and many neuronal cells were detected in the Ex+MCAo group (70.8+/-3.9%) compared to the MCAo group (43.4+/-5.1%) (p<.05). The immunoreactivity of laminin, as a marker of microvessels and Vascular endothelial growth factor (VEGF) were intensively increased in the Ex+MCAo group compared to the MCAo group. CONCLUSION: These findings suggest that the neuroprotective effects of exercise pre-conditioning reduce ischemic brain injury through strengthening the microvascular integrity after cerebral ischemia.
Animals
;
Brain Infarction/pathology
;
Disease Models, Animal
;
Infarction, Middle Cerebral Artery/metabolism/pathology/*prevention & control
;
Laminin/metabolism
;
Male
;
Microvessels/metabolism
;
Neurons/metabolism
;
*Physical Conditioning, Animal
;
Rats
;
Rats, Sprague-Dawley
;
Stroke/prevention & control
;
Vascular Endothelial Growth Factor A/metabolism
8.Aprepitant prophylaxis effectively reduces preventing postoperative nausea and vomiting in patients receiving opioid based intravenous patient-controlled analgesia.
Gwieun YEO ; Mi Kyoung LEE ; Heezoo KIM ; Myounghoon KONG ; Hyo Jung SON ; Han Byeol OH
Anesthesia and Pain Medicine 2018;13(3):256-263
BACKGROUND: Aprepitant is effective in prevention of chemotherapy-induced nausea and vomiting, when administrated with other antiemetics. We compared the effectiveness of aprepitant to ondansetron for prevention of post-operative nausea and vomiting (PONV) in patients who received a patient-controlled analgesia (PCA) containing opioids. METHODS: 198 patients were randomized into two groups. The treatment group was received an aprepitant, 80 mg, and the control group received a placebo. General anesthesia with inhalational anesthetics–N2O was performed, and PCA was supplied, which contained opioids-NSAIDs-ondansetron. The primary end-point was the incidence of PONV for postoperative 48 hours, and the secondary end-point was the changes in the relationship between PONV incidence and risk factors. RESULTS: PONV incidence in the treatment group was lower than in the control group (18.6% [95% CI: 10.8–26.3], 33.3% [95% CI: 23.6–43.1], respectively, P = 0.021). Relative risk of PONV in the control group was 1.80 (95% CI: 1.08–3.00, P = 0.010). PONV scores peaked at around postoperative 6 hours, then gradually decreased in the control group but not in the treatment group, which showed lower values than the control group (P = 0.001), and no changing patterns were observed (P < 0.001). Risk factors analyzed were sex, surgery type, history of motion sickness or PONV, and smoking habits. Their effects of all risk factors except sex were abolished in the treatment group. CONCLUSIONS: Prophylactic aprepitant with ondansetron was more effective than ondansetron-only regimen in preventing PONV after volatile anesthesia with opioid-containing PCA. Aprepitant abolished the effects of most of risk factors, so it could be efficacious in a high-risk PONV group.
Analgesia, Patient-Controlled*
;
Analgesics, Opioid
;
Anesthesia
;
Anesthesia, General
;
Antiemetics
;
Humans
;
Incidence
;
Motion Sickness
;
Nausea
;
Ondansetron
;
Passive Cutaneous Anaphylaxis
;
Postoperative Nausea and Vomiting*
;
Pre-Exposure Prophylaxis
;
Risk Factors
;
Smoke
;
Smoking
;
Vomiting
9.Safety and Efficacy of Bone Cement (Spinofill®) for Vertebroplasty in Patients with Osteoporotic Compression Fracture : A Preliminary Prospective Study
Han Byeol PARK ; Seong SON ; Jong Myung JUNG ; Sang Gu LEE ; Byung Rhae YOO
Journal of Korean Neurosurgical Society 2022;65(5):730-740
Objective:
: Although several commercialized bone cements are used during percutaneous vertebroplasty (PVP) for patients with osteoporotic vertebral compression fracture (OVCF), there are no reports using domestic products from South Korea. In this study, we investigated the safety and efficacy of Spinofill® (Injecta Inc., Gunpo, Korea), a new polymethyl methacrylate product.
Methods:
: A prospective, single-center, and single-arm clinical trial of 30 participants who underwent PVP using Spinofill® for painful thoracolumbar OVCF was performed with 6-months follow-up. Clinical and surgical outcomes included the Visual analog scale (VAS), Korean-Oswestry disability index (K-ODI), and Odom’s criteria, complication rate, and recurrence rate. Radiological outcomes were evaluated by measuring the findings of postoperative computed tomography and simple radiograph.
Results:
: The pain of VAS (from 8.95±1.05 to 4.65±2.06, p<0.001) and the life quality based on K-ODI (from 33.95±5.84 to 25.65±4.79, p<0.001) improved significantly, and successful patient satisfaction were achieved in 20 patients (66.7%) 1 day after surgery. These immediate improvements were maintained or more improved during the follow-up. There was no surgery- or product-related complications, but OVCF recurred in two patients (6.7%). Favorable cement interdigitation was reported in 24 patients (80.0%), and extra-vertebral cement leakage was reported in 13 patients (43.0%). The mean vertebral height ratio (from 60.49%±21.97% to 80.07%±13.16%, p<0.001) and segmental kyphotic angle (from 11.46°±8.50° to 7.79°±6.08°, p=0.002) improved one day after surgery. However, these short-term radiological findings somewhat regressed at the end.
Conclusion
: The overall outcomes of PVP using Spinofill® were as favorable as those of other conventionally used products.
10.Validation of high-sensitivity troponin I levels for major adverse cardiac events in low risk chest pain patients
Hyun Jin RYU ; Ha Young PARK ; Tae Sik HWANG ; Han Byeol KIM ; Ju Hong LEE
Journal of the Korean Society of Emergency Medicine 2023;34(6):586-598
Objective:
This study examined whether the efficiency of the level of detection (LOD) and upper reference limit (URL) for high-sensitivity cardiac troponin I (hs-cTnI) is increased when major adverse cardiovascular events (MACEs) occur in patients with low-risk chest pain who visit the emergency department (ED) and how long they stay in the ED.
Methods:
The URL for hs-cTnI used in the hospital improved from 0.04 ng/mL (LOD <0.0041 ng/mL) in 2018 to 19.8 pg/mL (LOD <2.3 pg/mL) in 2019. In these two years, the occurrence of MACEs, frequency of hs-cTnI follow-up in the ER, and the length of stay in the ER were compared. In addition, the three calculated risk assessment scores for the safety level of early discharge were compared.
Results:
In 2018, there were six MACEs out of 120 patients (5.0%), no cardiac deaths, one acute myocardial infarction (AMI), and five unplanned coronary revascularizations. In 2019, six MACEs out of 105 patients (5.7%) were all unplanned coronary revascularizations without any cardiac deaths or AMIs.
Conclusion
Although the level of hs-cTnI measurement was improved, there was no difference in the incidence of MACEs in patients with low-risk chest pain who were discharged from the ED, and the number of hs-cTnI follow-ups and time in the ED increased. Interestingly, there were only short-term MACEs and no medium-term MACEs. In addition, there was little to no coronary artery occlusion disease. The risk assessment score combined with hs-cTnI improved the predictive performance for MACEs.