Background: The effects of soy extract on memory as well as the oxidative damage to brain tissue induced by ischemia was investigated in ovariectomised (OVX) rats. Methods: The rats were divided into: 1) Sham; 2) OVX; 3) Sham‑Ischemia; 4) OVX‑Ischemia; 5) OVX-‑Ischemia-‑S 20; and 6) OVX-‑Ischemia-‑S 60. The common carotid artery was occluded (30 minutes), and it was then re-‑perfused. The OVX-‑Ischemia-‑S 20 and OVX-‑Ischemia-‑S 60 groups received 20 or 60 mg/kg of soy extract for eight weeks before the ischemia. Results: The Sham-‑Ischemia and OVX-‑Ischemia groups took a longer time to reach the platform while, spent a shorter time in the target quadrant (Q1) than the Sham and OVX. The escape latencies in the OVX-‑Ischemia-‑S 20 and OVX-‑Ischemia-‑S 60 groups were lower while, time spent in the Q1 was higher than that of the OVX-‑Ischemia. In the rotarod test, there were no significant differences between the groups. The hippocampal concentrations of malondialdehyde (MDA) in the Sham-‑Ischemia and OVX-‑Ischemia groups were higher than the Sham and OVX. Pre-‑treatment by 20 and 60 mg/kg of the extract reduced the MDA. Conclusion: It is suggested that soy prevents memory impairment and brain tissue oxidative damage due to ischemia in OVX rats.

Objective: To investigate the parasitic infection status of cyprinid fish, Capoeta damascina in Gomban spring-stream, Kor River Basin, Fars Province, southwestern Iran.Methods:stream, Kor River Basin, Fars Province, southwestern Iran. The collected fish were dissected carefully and their internal organs such as liver, gonad, muscle, abdominal lobes, whole viscera and digestive tract were surveyed parasitologically.Results:One female cyprinid fish out of 12 fish was infected with three nematodes. Two A total of 12 cyprinid fish (7 females and 5 males) were collected from Gomban spring-nematodes (larvae) were identified as Contracaecum sp. which were attached firmly to the outer part of intestine and another adult helminth was recognized as Capillaria sp. which was recovered from digestive content.Conclusions:This study is the first record indicating that cyprinid fish acts as a new host for recovered nematodes. Further helminthological investigations are highly recommended in different parts of Iran in order to expand our knowledge about helmintic parasites of cyprinid fish and their role in transmission of diseases to human and animal.

Strongyloides stercoralis is a human intestinal parasite which may lead to complicated strongyloidiasis in immunocompromised. Here, a case of complicated strongyloidiasis in a patient with chronic lymphocytic leukemia is reported. Presence of numerous S. stercoralis larvae in feces and sputum confirmed the diagnosis of hyperinfection syndrome in this patient. Following recovery of filariform larvae from agar plate culture of the stool, the isolate was characterized for the ITS1 region of ribosomal DNA gene by nested-PCR and sequencing. Albendazole therapy did not have cure effects; and just at the beginning of taking ivermectin, the patient died. The most important clue to prevent such fatal consequences is early diagnosis and proper treatment.
Aged ; Albendazole/therapeutic use ; Animals ; Anthelmintics/therapeutic use ; Fatal Outcome ; Humans ; Ivermectin/therapeutic use ; Larva ; Leukemia, Lymphocytic, Chronic, B-Cell/*complications/parasitology ; Male ; Strongyloides stercoralis/*classification ; Strongyloidiasis/*complications/drug therapy

OBJECTIVES: Antibiotic exposure in children is a possible contributor to the increasing asthma prevalence in several countries. The present study aimed to investigate the association between antibiotic exposure and the risk of developing childhood asthma at 2-8 years of age. METHODS: A case-control study was undertaken among children aged 2-8 years old between March and September 2010 in the Urmia district in the northwest of Iran. The cases were doctor-diagnosed asthmatic children based on Global Initiative for Asthma criteria (n=207), and the controls were children without respiratory symptoms (n=400) selected by frequency matching by age and gender. Clinical data including antibiotic exposure was collected by a validated and reliable questionnaire, which was completed by interviewing parents/guardians. RESULTS: Antibiotic consumption during the first year of life increased the odds ratio [OR] of asthma symptoms at 2-8 years of age (crude OR, 2.26; 95% confidence interval [CI], 1.53-3.35; p<0.01), and the strength of association was similar after adjusting for a family history of asthma or atopic disorder, preterm delivery, birth order, and delivery method (adjusted OR, 1.91; 95% CI, 1.27-2.88; p=0.03). CONCLUSIONS: Our study suggests that antibiotic consumption in children was associated with an increased risk of childhood asthma, and an additional confirmative study is needed.
Asthma* ; Birth Order ; Case-Control Studies ; Child* ; Humans ; Iran ; Odds Ratio ; Prevalence ; Surveys and Questionnaires

OBJECTIVETo investigate the parasitic infection status of cyprinid fish, Capoeta damascina in Gomban spring-stream, Kor River Basin, Fars Province, southwestern Iran.

METHODSA total of 12 cyprinid fish (7 females and 5 males) were collected from Gomban spring-stream, Kor River Basin, Fars Province, southwestern Iran. The collected fish were dissected carefully and their internal organs such as liver, gonad, muscle, abdominal lobes, whole viscera and digestive tract were surveyed parasitologically.

RESULTSOne female cyprinid fish out of 12 fish was infected with three nematodes. Two nematodes (larvae) were identified as Contracaecum sp. which were attached firmly to the outer part of intestine and another adult helminth was recognized as Capillaria sp. which was recovered from digestive content.

CONCLUSIONSThis study is the first record indicating that cyprinid fish acts as a new host for recovered nematodes. Further helminthological investigations are highly recommended in different parts of Iran in order to expand our knowledge about helmintic parasites of cyprinid fish and their role in transmission of diseases to human and animal.