1.Hypersensitivity Pneumonitis: Radiological, Clinical and Pathologic Evaluation.
Seog Hee PARK ; Jeong Sup SONG ; Kyung Sub SHINN ; Hak Hee KIM ; Kyo Young LEE ; Jeong Mi PARK ; Eun Ja LEE ; Young Shin KIM ; Chun Yul KIRN
Journal of the Korean Radiological Society 1994;31(3):471-476
PURPOSE: This paper is to evaluate radiological features of hypersensitivity pneumonitis, correlated with clinical and pathologic findings. MATERIALS AND METHODS: Patients consisted of 2 men and 3 women, aged 23-51 years old (average 41). Diagnosis was based on the presence of suggestive clinical and radiological findings (chest radiography, high resolutional CT, gallium scintigraphy), and lung biopsy showing characteristic histological features. RESULTS: All patients complained of exertional dyspnea and three patients experienced coughing. On the pulmonary function test, four patients revealed restrictive pattern and one patient was normal. Results of bronchoalveolar lavage, available in four patients, revealed lymphocytosis in three patients and normal finding in one patient. Chest radiographs showed ground glass opacity or diffuse nodular densities. On the HRCT, diffuse nodular opacity and ground glass opacity were seen in variable features. All 4 patients had diffuse increased uptake on the gallium scan. On lung biopsy, a combination of histologic findings showed cellular bronchiolitis, diffuse interstitial infiltrates and non-necrotizing granulomas, consistent with diagnosis of hypersensitivity pneumonitis. CONCLUSION: Hypersensitivity pneumonitis could be diagnosed with these radiological, clinical and pathological findings.
Alveolitis, Extrinsic Allergic*
;
Biopsy
;
Bronchiolitis
;
Bronchoalveolar Lavage
;
Cough
;
Diagnosis
;
Dyspnea
;
Female
;
Gallium
;
Glass
;
Granuloma
;
Humans
;
Hypersensitivity*
;
Lung
;
Lymphocytosis
;
Male
;
Radiography
;
Radiography, Thoracic
;
Respiratory Function Tests
2.Radiologic Findings of Metastatic Tumors to the Breast.
Sang Heum KIM ; Eun Suk CHA ; Jeong Mi PARK ; Hak Hee KIM ; Ji Young KIM ; Young Ha PARK ; Kyung Sub SHINN
Journal of the Korean Radiological Society 1999;41(3):601-606
PURPOSE: To analyze the radiologic findings of metastatic tumors of the breast. MATERIALS AND METHODS: We retrospectively analyzed the findings of mammography (n=12), ultrasonography (n=9) and CT (n=4) of 13 patients with metastatic tumors of the breast. Methods for confirmation were biopsy (n=8) and clinical follow-up (n=5). The patient's ages ranged from 24 to 63 (mean 43) years. RESULTS: Primary malignancies were contralateral breast cancer (n=3), non-Hodgkin's lymphoma (n=3), stomach cancer (n=2), uterine cervix cancer (n=1), laryngeal cancer (n=1), esophageal melanoma (n=1), malignant thymoma (n=1), and lung cancer (n=1). Patterns of metastasis from contralateral breast cancer and the stomach cancer were diffuse and infiltrative, while metastasis from other cancers was of the focal massforming type. The radiologic findings of metastasis from contralateral breast cancer (n=3) were diffuse skin thickening and increased density or echogenicity in the medial aspect of the breast, while in cases involving metastasis from stomach cancer (n=2) radiographs revealed extensive skin thickening, increased density or echogenicity, lymphedema and ipsilateral lymphadenopathy in the left breast. In cases of metastatic tumors to the breast in which focal masses were seen on mammography (n=7), marginal spiculation or microcalcification of the tumors was not present. In six such cases, ultrasonography revealed well-defined margin, posterior acoustic shadowing or an irregular thick echogenic boundary was not seen. In two patients who underwent CT scanning, well-defined masses with moderate contrast enhancement were present. CONCLUSION: Radiographs of metastatic tumors to the breast from contralateral breast cancer and stomach cancer showed diffuse infiltration. The metastatic tumors with focal masses showed oval to round, smooth-marginated, well-defined masses without spiculation or microcalcification on mammography, and a well-defined mass without posterior acoustic shadowing or irregular thick echogenic boundary on ultrasonography.
Acoustics
;
Biopsy
;
Breast Neoplasms
;
Breast*
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Cervix Uteri
;
Female
;
Follow-Up Studies
;
Humans
;
Laryngeal Neoplasms
;
Lung Neoplasms
;
Lymphatic Diseases
;
Lymphedema
;
Lymphoma, Non-Hodgkin
;
Mammography
;
Melanoma
;
Neoplasm Metastasis
;
Retrospective Studies
;
Shadowing (Histology)
;
Skin
;
Stomach Neoplasms
;
Thymoma
;
Tomography, X-Ray Computed
;
Ultrasonography
3.Pseudoaneurysm Due to Squamous Cell Carcinoma of the Lung: Two Cases of Spontaneous Resolution after Chemotherapy.
So Young KIM ; Hak Ryul KIM ; Jung Sub SONG ; Ki Eun HWANG ; Jeong Hyun SHIN ; Seoung Nam SHIN ; Dong KIM ; Seong Hoon PARK ; Sei Hoon YANG ; Eun Taik JEONG
Cancer Research and Treatment 2009;41(4):237-240
Pseudoaneurysm due to cancer is uncommon generally and is extremely rare in lung cancer. We report two cases of false aneurysms due to lung cancer that spontaneously regressed upon chemotherapy without intervention. Both patients had squamous cell carcinoma of the lung and the diagnosis of a pseudoaneurysm was made using computed tomography. There was no evidence of severe bronchial hemorrhage and the psuedoaneurysms were small and well-encased. Chemotherapy was performed and the pseudoaneurysms resolved.
Aneurysm
;
Aneurysm, False
;
Carcinoma, Squamous Cell
;
Hemorrhage
;
Humans
;
Lung
;
Lung Neoplasms
4.First Blindness Cases of Horses Infected with Setaria Digitata (Nematoda: Filarioidea) in the Republic of Korea.
Jihun SHIN ; Kyu Sung AHN ; Guk Hyun SUH ; Ha Jung KIM ; Hak Sub JEONG ; Byung Su KIM ; Eunsang CHOI ; Sung Shik SHIN
The Korean Journal of Parasitology 2017;55(6):667-671
Ocular setariases of cattle were reported but those of equine hosts have never been reported in the Republic of Korea (Korea). We found motile worms in the aqueous humor of 15 horses (Equus spp.) from 12 localities in southern parts of Korea between January 2004 and November 2017. After the affected animals were properly restrained under sedation and local anesthesia, 10 ml disposable syringe with a 16-gauge needle was inserted into the anterior chamber of the affected eye to successfully remove the parasites. The male worm that was found in 7 of the cases showed a pair of lateral appendages near the posterior terminal end of the body. The papillar arrangement was 3 pairs of precloacal, a pair of adcloacal, and 3 pairs of postcloacal papillae, plus a central papilla just in front of the cloaca. The female worms found in the eyes of 8 horses were characterized by the tapering posterior terminal end of the body with a smooth knob. Worms were all identified as Setaria digitata (von Linstow, 1906) by the morphologic characteristics using light and electron microscopic observations. This is the first blindness cases of 15 horses infected with S. digitata (Nematoda: Filarioidea) in Korea.
Anesthesia, Local
;
Animals
;
Anterior Chamber
;
Aqueous Humor
;
Blindness*
;
Cattle
;
Cloaca
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Female
;
Horses*
;
Humans
;
Korea
;
Male
;
Needles
;
Parasites
;
Republic of Korea*
;
Setariasis
;
Syringes
5.Power Doppler Ultrasound Findings of Renal Infarct after Experimental Renal Artery Occlusion: Comparison withSpiral CT.
Seung Eun JUNG ; Kyung Sub SHINN ; Hak Hee KIM ; Seok Hwan MUN ; Young Joon LEE ; Bae Young LEE ; Byung Gil CHOI ; Jae Mun LEE ; Hee Jeong LEE
Journal of the Korean Radiological Society 1999;40(2):307-315
PURPOSE: To evaluate the efficacy of power Doppler ultrasonography (PDUS) in depicting renal infarction inrabbits during experimental renal segmental arterial occlusion, and to compare the results with those of CTscanning. MATERIALS AND METHODS: In 28 rabbits weighing 2.5-4kg, the segmental renal artery was occluded throughthe left main renal artery by embolization with Ivalon (Nycomed, Paris, France). Power Doppler ultrasonography andspiral CT scanning were performed before and at 2, 5, 8, 15, and 24 hours, and 3 and 7 days after occlusion of thesegmental renal artery. The location of infarcted areas and collaterals, as seen on PDUS and CT scans, wasevaluated by two radiologists. RESULTS: In all cases, as seen on power Doppler ultrasonography, infaretedareas-when compared with normal parenchyma, clearly demonstrated wedge-shaped perfusion defects in the kidney. Thelocation of the lesion closely corresponded to the location seen during CT scanning. After renal arterialocclusion, transiently congested capsular arteries, which were named 'capsular sign', were seen in 63% ofrabbits in the two and five-hour groups. No significant cortical rim sign was demonstrated on power Dopplerultrasonography, though it was noted on spiral CT at 15 and 24 hours, and 3 and 7 days after renal arterialocclusion. CONCLUSION: Power Doppler ultrasonography was useful for the diagnosis of renal infarction. Congestedcapsular artery seen in the early stage of renal infarction might be a characteristic finding of this condition,as seen on power Doppler ultrasonography.
Animals
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Arteries
;
Diagnosis
;
Estrogens, Conjugated (USP)
;
Infarction
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Kidney
;
Perfusion
;
Rabbits
;
Renal Artery*
;
Tomography, Spiral Computed
;
Tomography, X-Ray Computed
;
Ultrasonography*
;
Ultrasonography, Doppler
6.The Role and Significance of Biomarker for Plasma G-CSF in Patients with Primary Lung Cancer.
Jung Sub SONG ; So Young KIM ; Hyang Jeong JO ; Kang Kyoo LEE ; Jeong Hyun SHIN ; Seong Nam SHIN ; Dong KIM ; Seong Hoon PARK ; Young Jin LEE ; Chang Bo KO ; Mi Kung LEE ; Soon Ho CHOI ; Jong Hoon JEONG ; Jung Hyun PARK ; Hui Jung KIM ; Hak Ryul KIM ; Eun Taik JEONG ; Sei Hoon YANG
Tuberculosis and Respiratory Diseases 2009;66(6):444-450
BACKGROUND: Biomarkers for cancer have several potential clinical uses, including the following: early cancer detection, monitoring for recurrence prognostication, and risk stratification. However, no biomarker has been shown to have adequate sensitivity and specificity. Many investigators have tried to validate biomarkers for the early detection and recurrence of lung cancer. To evaluate plasma G-CSF as such a biomarker, protein levels were measured and were found to correlate with the clinicopathological features of primary lung tumors. METHODS: Between December 2006 and May 2008, 100 patients with histologically-validated primary lung cancer were enrolled into this study. To serve as controls, 127 healthy volunteers were enrolled into this study. Plasma G-CSF levels were measured in lung cancer patients using the sandwich ELISA system (R & D inc.) prior to treatment. RESULTS: The mean plasma G-CSF levels were 12.2+/-0.3 pg/mL and 46.0+/-3.8 pg/mL (mean+/-SE) in the normal and in the cancer groups, respectively. In addition, plasma G-CSF levels were higher in patients with early lung cancer than in healthy volunteers (p<.001). Plasma G-CSF levels were higher in patients who were under 65 years old or smokers. Within the cancer group, plasma G-CSF levels were higher in patients with non small cell lung cancer than in patients with small cell lung cancer (p<.05). Overall, plasma G-CSF levels were shown to increase dependent upon the type of lung cancer diagnsosed. In the order from highest to lowest, the levels of plasma G-CSF tended to decrease in the following order: large cell carcinoma, squamous cell carcinoma, adenocarcinoma, and bronchioloalveolar carcinoma. Plasma G-CSF levels tended to be higher in patients with advanced TNM stage than in localized TNM stage (I, II
7.The Clinical and Histopathologic Features according to Loss of LKB1 Protein Expression on Primary Lung Cancer.
Ki Eun HWANG ; Hyang Jeong JO ; Kang Kyoo LEE ; Hyeok SHIM ; Jung Sub SONG ; Jeong Hyun SHIN ; Seong Nam SHIN ; Seong Hoon PARK ; Kyeong Man HONG ; Jung Hyun PARK ; Jong Hoon JEONG ; Hui Jung KIM ; Hak Ryul KIM ; Sei Hoon YANG ; Eun Taik JEONG
Tuberculosis and Respiratory Diseases 2008;64(5):362-368
BACKGROUND: LKB1(STK11) is a serine/threonine kinase that functions as a tumor growth suppressor. The functions of LKB1 in lung cancer are not completely understood. This study evaluated the relationship between LKB1 protein expression and the clinicopathological features in lung cancer tissues. METHODS: The expression of LKB1 was studied in paraffin-embedded tumor blocks, which were obtained from 77 patients who had undergone surgery at Wonkwang University Hospital. The expression of the LKB1 protein was considered positive if the staining intensity in the tumor tissue adjacent to the normal airway epithelium was >30%. RESULTS: The LKB1 expression was positive in 31 (40%) of samples. Loss of LKB1 expression was significantly associated with being male, smoking history, and squamous cell carcinoma. In the peripheral sites, the loss of LKB1 expression was strongly associated with a smoking history. A loss of LKB1 expression was more frequently associated with progression according to TNM staging, particularly more than T2, N progression. CONCLUSION: There was a significant relationship between the loss of the LKB1 protein and gender, smoking history, and histological type in primary lung cancer. Although LKB1 expression was not found to be a significant prognostic factor, further studies with a larger cohort of patient's lung cancer tissue samples will be needed to confirm this.
Carcinoma, Squamous Cell
;
Cohort Studies
;
Epithelium
;
Humans
;
Lung
;
Lung Neoplasms
;
Male
;
Neoplasm Staging
;
Phosphotransferases
;
Smoke
;
Smoking
8.Two Cases of Chemical Pneumonitis Induced by Hydrocarbon Aspiration.
Dong Hyo NOH ; Hak Ryul KIM ; Kyung Hwa CHO ; Dong KIM ; Seong Nam SHIN ; Jeong Hyun SHIN ; Jung Sub SONG ; Ki Eun HWANG ; So Young KIM ; Hwi Jung KIM ; Sei Hoon YANG ; Eun Taik JEONG
Tuberculosis and Respiratory Diseases 2009;67(2):148-153
Chemical pneumonitis induced by hydrocarbon aspiration is rare in Korea. Kerosene is a petroleum distillate with low viscosity and high volatility. We report two adult cases of chemical pneumonitis caused by the accidental aspiration of kerosene. They were treated successfully with antibiotics and systemic corticosteroids, and recovered without complications.
Adrenal Cortex Hormones
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Adult
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Anti-Bacterial Agents
;
Humans
;
Kerosene
;
Korea
;
Petroleum
;
Pneumonia
;
Viscosity
;
Volatilization
9.Central Venous Catheterization Via Persistent Left Superior Vena Cava.
Nam Sub LEE ; Hak Jun SEO ; Kee Hwan KIM ; Ji Il KIM ; Chang Hyk AHN ; Jeong Soo KIM ; Sung Jin YU ; Keun Woo LIM ; Young Mi KU ; Sun Wha SONG
Journal of the Korean Surgical Society 2004;66(5):444-446
Although the use of central venous cannulation has been increasing in recent years, it can produce serious complications such as hemothorax, pneumothorax, arterial puncture, and malposition of the catheter. Therefore, post-procedure chest radiograph must be obtained to confirm correct placement of the catheter and to exclude pneumothorax or hemothorax. We experienced an abnormal course of left subclavian catheter along the left border of the heart on post-procedure chest radiograph. Here we report a case of persistent left superior vena cava detected by hemodialysis catheterization in a patient with acute renal failure after ruptured abdominal aortic aneurysm.
Acute Kidney Injury
;
Aortic Aneurysm, Abdominal
;
Catheterization
;
Catheterization, Central Venous*
;
Catheters
;
Central Venous Catheters*
;
Heart
;
Hemothorax
;
Humans
;
Pneumothorax
;
Punctures
;
Radiography, Thoracic
;
Renal Dialysis
;
Vena Cava, Superior*
10.Survey-Based Analysis of the Clinical Treatment Status of Irritable Bowel Syndrome in Korea
Hoon Sup KOO ; Hui Chang SON ; Hong Sub LEE ; Hyeon Jeong GOONG ; Ju Seok KIM ; Ki Bae KIM ; Yong Hwan KWON ; Jae Hak KIM ; Hyun Deok SHIN ; Ji Eun SHIN ; Sam Ryong JEE
Journal of Korean Medical Science 2023;38(16):e126-
Background:
The quality-of-life of patients with irritable bowel syndrome is low; incorrect diagnosis/treatment causes economic burden and inappropriate consumption of medical resources. This survey-based study aimed to analyze the current status of irritable bowel syndrome treatment to examine differences in doctors’ perceptions of the disease, and treatment patterns.
Methods:
From October 2019 to February 2020, the irritable bowel syndrome and Intestinal Function Research Study Group of the Korean Society of Neurogastroenterology and Motility conducted a survey on doctors working in primary, secondary, and tertiary healthcare institutions. The questionnaire included 37 items and was completed anonymously using the NAVER platform (a web-based platform), e-mails, and written forms.
Results:
A total of 272 doctors responded; respondents reported using the Rome IV diagnostic criteria (amended in 2016) for diagnosing and treating irritable bowel syndrome.Several differences were noted between the primary, secondary, and tertiary physicians’ groups. The rate of colonoscopy was high in tertiary healthcare institutions. During a colonoscopy, the necessity of random biopsy was higher among physicians who worked at tertiary institutions. ‘The patient did not adhere to the diet’ as a reason for ineffectiveness using low-fermentable oligo-, di-, and mono-saccharides, and polyols diet treatment was higher among physicians in primary/secondary institutions, and ‘There are individual differences in terms of effectiveness’ was higher among physicians in tertiary institutions. In irritable bowel syndrome constipation predominant subtype, the use of serotonin type 3 receptor antagonist (ramosetron) and probiotics was higher in primary/secondary institutions, while serotonin type 4 receptor agonist was used more in tertiary institutions. In irritable bowel syndrome diarrhea predominant subtype, the use of antispasmodics was higher in primary/secondary institutions, while the use of serotonin type 3 receptor antagonist (ramosetron) was higher in tertiary institutions.
Conclusion
Notable differences were observed between physicians in primary/secondary and tertiary institiutions regarding the rate of colonoscopy, necessity of random biopsy, the reason for the ineffectiveness of low-fermentable oligo-, di-, and mono-saccharides, and polyols diet, and use of drug therapy in irritable bowel syndrome. In South Korea, irritable bowel syndrome is diagnosed and treated according to the Rome IV diagnostic criteria, revised in 2016.