1.3 cases of granurocytic sarcoma in CNS.
Hyung Kyoo SHIN ; Chang Sik CHAE ; Hwan Tae KIM ; Ki Jung CHO ; Chang Hak SON
Journal of the Korean Cancer Association 1993;25(5):785-792
No abstract available.
Sarcoma*
2.Effects of Carbogen Inhalation and Stellate Ganglion Block in the Treatment of Idiopathic Sudden Sensorineural Hearing Loss.
Korean Journal of Otolaryngology - Head and Neck Surgery 2002;45(3):219-224
BACKGROUND AND OBJECTIVES: Impairment of inner ear circulation may be one of the pathophysiology of idiopathic sudden sensorineural hearing loss (ISSNHL). Carbogen inhalation therapy, in which patients breathe a gas mixture of 5% CO2 and 95% O2 by mask, and a stellate ganglion block (SGB) are potent vasodilatation and tissue oxygenation procedures widely used as treatment modalities in ISSNHL. The purpose of this study was to compare the effectiveness of each modality and to find out the differences in the effectiveness of carbogen inhalation therapy and SGB. MATERIALS AND METHOD: We reviewed the records of 313 patients who were admitted to the Masan Samsung Hospital from January 1995 to December 2000 for investigation of the efficacy of carbogen inhalation therapy and SGB. One hundred and thirty-one patients were treated with carbogen inhalation, SGB and drug medication, and 57 patients without SGB and 125 patients were treated with medication only. RESULTS: Therapeutic results of carbogen inhalation and SGB group was better than that of medication only group. But no statistical differences were found between the carbogen inhalation and SGB group. CONCLUSION: These results suggest that carbogen inhalation and SGB were effective treatment modalities of ISSNHL. We recommend that carbogen inhalation therapy and SGB could be utilized as the standard treatment of ISSNHL.
Ear, Inner
;
Hearing Loss, Sensorineural*
;
Humans
;
Inhalation*
;
Masks
;
Oxygen
;
Respiratory Therapy
;
Stellate Ganglion*
;
Vasodilation
3.Mortality Study of Intertrochanteric Fractures of the Femur in the Elderly Patients
Keun Woo KIM ; Yong Hoon KIM ; Hak Jin MIN ; Ui Seoung YOON ; Woong Je CHO ; Dong Seok SON
The Journal of the Korean Orthopaedic Association 1996;31(1):119-123
Intertrochanteric fractures are common in older age group. Recently better implant design and surgical technique have improved clinical results. But still many patients suffer from high morbidity and mortality, because of accompanying osteoporosis and various senile diseases. From January 1991 to June 1994, we treated 54 patients older than 70 years with intertrochanteric fractures of femur. Among them, 23 patients were followed up at our hospital and the other patients were informed from police station. Lost follow up was ten patients and final follow up were 44 patients. Mortality was analyzed for the detection of causative factors, such as age, sex, associated medical problems. type of fracture, degree of osteoporosis, type of operation, internal between injury and operation and duration of admission. The results were as follows; 1. 26 patients survived and 18 patients died(Mortality rate :40.9%) 2. 10 patients died within 1 year(Mortality rate :22.7%) 3. Mortality was related to associated medical problems, interval between in jury and operation and type of fracture, which were statistically significant(P < 0.05).
Aged
;
Femur
;
Follow-Up Studies
;
Hip Fractures
;
Humans
;
Mortality
;
Osteoporosis
;
Police
4.Temporospatial clustering analysis of foot-and-mouth disease transmission in South Korea, 2010~2011.
Sun Hak BAE ; Yeun Kyung SHIN ; Byunghan KIM ; Son Il PAK
Korean Journal of Veterinary Research 2013;53(1):49-54
To investigate the transmission pattern of geographical area and temporal trends of the 2010~2011 foot-and-mouth disease (FMD) outbreaks in Korea, and to explore temporal intervals at which spatial clustering of FMD cases space-time analysis based on georeferenced database of 3,575 burial sites, from 30 November 2010 to 23 February 2011, was performed. The cases represent approximately 98.1% of all infected farms (n = 3,644) during the same period. Descriptive maps of spatial patterns of the outbreaks were generated by ArcGIS. Spatial Scan Statistics, using SaTScan software, was applied to investigate geographical clusters of FMD cases across the country. Overall, spatial heterogeneity was identified, and the transmission pattern was different by province. Cattle have more clusters in number but smaller in size, as compared to the swine population. In addition, spatiotemporal analysis and the comparison of clustering patterns between the first 7 days and days 8 to 14 of the outbreak revealed that the strongest spatial clustering was identified at the 7-day interval, although clustering over longer intervals (8~14 days) was also observed. We further discussed the importance of time period elapsed between FMD-suspected notice and the date of confirmation, and emphasized the necessity of region-specific and species-specific control measures.
Animals
;
Burial
;
Cattle
;
Disease Outbreaks
;
Foot-and-Mouth Disease
;
Geographic Information Systems
;
Korea
;
Population Characteristics
;
Republic of Korea
;
Spatial Analysis
;
Spatio-Temporal Analysis
;
Swine
5.Thymic Carcinoma: Report of Eight Cases.
Young Don JOO ; Joon Hee KIM ; Chang Hak SON ; Ye Hoe KIM ; Chan Hwan KIM ; Hyun Sook SEO
Journal of the Korean Cancer Association 1998;30(4):743-751
Thymic carcinoma is a rare malignant neoplasm of the thymic epithelium, distinguished from benign or invasive thymoma by the presence of malignant cytology and a greater incidence of local invasion and embolic metastases. The true incidence of this neoplasm is unknown. Nearly three fourth of their patients had symptoms of an anterior mediastinal mass, including cough, chest pain, and superior vena cava syndrome. These patients rarely have myasthenia gravis or other thymoma-associated paraneoplastic syndromes. The treatment of thymic carcinoma remains a controversial matter. We report eight cases of thymic carcinoma treated in our institution from 1990 to 1997.
Chest Pain
;
Cough
;
Epithelium
;
Humans
;
Incidence
;
Mediastinum
;
Myasthenia Gravis
;
Neoplasm Metastasis
;
Paraneoplastic Syndromes
;
Superior Vena Cava Syndrome
;
Thymoma*
6.Coronary Artery Bypass Graft Surgery in the Elderly.
Hak Jae KIM ; Jae Joon HWANG ; Hyun Goo KIM ; Jae Seung SHIN ; Young Sang SON ; Young Ho CHOI
The Korean Journal of Thoracic and Cardiovascular Surgery 1999;32(8):715-721
BACKGROUND:The number of old patients receiving coronary artery bypass grafting(CABG) is increasing. With the more recent advances in operative techniques, the age at which CABG is indicated has also increased. This study evaluated the risk factors associated with the hospital mortality and the morbidity following CABG in elderly patients. MATERIAL AND METHOD: Between March 1991 and June 1998, we retrospectively reviewed 45 consecutive patients aged 65 years or older who underwent CABG. We compared the data with the results of 179 patients under the age 65 years operated during the same period. RESULT: Mean age was 68+/-1.41 years(range 65 to 74 years). Emergency surgery was required in 4, and elective surgery in 41 patients. The mean number of distal anastomosis per patient was 3.62 +/-0.81 and mean aortic cross-cramp time was 69.84+/-18.5 minutes. Thirty patients had Canadian class III or IV preoperatively, but 43 patients had class I or II postoperatively. The left ventricular ejection fraction increased significantly from 54.23+/-10.62% preoperatively to 58.14+/-9.88% postoperatively(p<0.05). Postoperative complication was pneumonia in 2 patients, acute renal failure in 2 patients, sternal wound infection in 1 patient, and postoperative myocardial infarction in 1 patient. There were two postoperative deaths. The causes of deaths were low output syndrome in one patient, and sepsis due to pneumonia in the other patient. The hospital mortality was higher in the elderly group(4.4 versus 2.86%) but was not statistically significant(p>.05). Incremental risk factors for hospital deaths in the elderly were emergent operation, preoperative PTCA, postoperative use of IABP and postoperative ARF(p<0.05). The duration of hospital stay after operation was significantly longer for the elderly group than the younger group(19.27+/-12.51 vs 15.55+/-6.99 days; p<0.05). Follow-up was complete for 34 of the hospital survivors and ranged from 1 to 73 months(mean: 23.58+/-19.56 months). There was no late mortality of cardiac origin. CONCLUSION: Age is an important factor in selecting optimal management for elderly patients with coronary compromise, but age alone should not dictate the choice of therapy. Coronary artery bypass surgery in the elderly is associated with acceptable early mortality and excellent long-term results.
Acute Kidney Injury
;
Age Factors
;
Aged*
;
Cause of Death
;
Coronary Artery Bypass*
;
Coronary Vessels*
;
Emergencies
;
Follow-Up Studies
;
Hospital Mortality
;
Humans
;
Length of Stay
;
Mortality
;
Myocardial Infarction
;
Pneumonia
;
Postoperative Complications
;
Retrospective Studies
;
Risk Factors
;
Sepsis
;
Stroke Volume
;
Survivors
;
Wound Infection
7.Clinical analysis of chest trauma.
Seung Kye KIM ; Soon Pil HONG ; Je Moon SON ; Won Sang CHUNG ; Young Hak KIM ; Heng Ok JEE ; Joon Young LEE
The Korean Journal of Thoracic and Cardiovascular Surgery 1993;26(12):944-949
No abstract available.
Thorax*
8.Development of Computerized Anthropometric Analysis Model in Cleft Lip Nasal Deformity Using 3D Laser Scanned Facial Cast Model.
Suk Wha KIM ; Jong Lim PARK ; Jae Chan KIM ; Seung Hak BAEK ; Woo Gil SON
Journal of the Korean Society of Plastic and Reconstructive Surgeons 2008;35(3):303-308
PURPOSE: The purpose of this study is to develop three-dimensional computerized anthropometry(3DCA) and to compare its reliability and accuracy 3DCA with manual anthropometry(MA) for measurement of lips and nasal deformities in unilateral cleft lips and palate(UCLP) patients. METHODS: Samples were consisted of six UCLP patients whose facial plaster models were available immediately before and 3 months after the cleft lip surgery. MA of the facial plaster models was carried out using an electronic caliper. In 3DCA, three-dimensional auto- measuring program was used to digitize landmarks and to measure three-dimensional virtual facial models (3DVFM), which was generated with a laser scanner and 3D virtual modeling program. Intraclass correlation coefficients(ICC) were calculated to evaluate reliability and reproducibility of the variables in both methods, and Wilcoxon's signed rank test was done to investigate the difference in values of the same variables of facial models of each patient between two methods. RESULTS: All ICC values were higher than 0.8, so both methods could be considered reliable. Although most variables showed statistical differences between two methods(p<0.05), differences between mean values were very small and could be considered not significant in clinical situation. CONCLUSION: In clinical situation, 3DCA can be an objective, reliable and accurate tool for evaluation of lips and nasal deformities in the cleft patients.
Cleft Lip
;
Congenital Abnormalities
;
Electronics
;
Electrons
;
Humans
;
Lip
9.A Case of Mucocele of the Submandibular Gland.
Myoung Jong YOO ; Hak Son KIM ; Sang Ryeol SEOK ; Myung Gu KIM
Korean Journal of Otolaryngology - Head and Neck Surgery 2001;44(4):441-444
Cysts of the salivary gland are non-neoplastic, localized lesions of the duct system. They form about 6 % of lesions of the salivary glands. Mucoceles represent more than 70% of the salivary cysts and usually arise from minor salivary glands; however, major salivary glands, especially the sublingual glands, may also be involved. Characteristically, mucoceles consist of a soft fluctuant bluish or translucent swelling which contain mucus, varying in size. They are most commonly found on the lower lip, but may also occur on the buccal mucosa, floor of the mouth, palate, upper lip, and tongue. They are found in all age groups but are most frequent in children and young adults. There are two types of mucoceles-one in which mucus has extravasated into the tissues (extravasation cyst) and one which is lined with epithelium (retention cyst). Recently, we experienced an unusual case of huge extravasation mucocele arising from the submandibular gland. The mucocele and submandibular gland were completely excised surgically, which were confirmed by computed tomographic scanning and histopathologic examination.
Child
;
Epithelium
;
Humans
;
Lip
;
Mouth
;
Mouth Mucosa
;
Mucocele*
;
Mucus
;
Palate
;
Salivary Glands
;
Salivary Glands, Minor
;
Sublingual Gland
;
Submandibular Gland*
;
Tongue
;
Young Adult
10.PCR and RFLP-based CYP2D6(B) and CYP2D6(T) Genotyping for Korean Lung Cancer Cases and Controls.
Jin Ho CHUN ; Chang Hee LEE ; Sang Hwa URM ; Byung Chul SON ; Jun Han PARK ; Kui Oak JUNG ; Chang Hak SOHN ; Hye Kyoung YOON ; Choon Hee SON ; Hyung In KIM ; Jin Seok KIM
Korean Journal of Preventive Medicine 1998;31(1):1-14
The genetically determined CYP2D6 activity is considered to be associated with cancer susceptibility with inter-individual variation. Genetic polymorphism of CYP2D6(B) and CYP2D6(T) was determined by the two polymerase chain reaction(PCR) and BstN1 and EcoN1 restriction fragment length polymorphisms(RFLP) for 67 lung cancer cases and 95 healthy volunteer controls. The cases were composed of 26 squamous cell carcinoma, 14 small cell carcinoma, 10 adenocarcinoma, 3 large cell undifferentiated carcinoma, and 14 not histologically diagnosed. The results were gained from the 142 subjects (57 cases and 85 controls) who observed successfully in two PCR and BstN1/EcoN1 RFLP. Only one and no mutant allele of the CYP2D6(B) and CYP2D6(T) gene was detected, that is, the frequency of mutant allele was very low; 0.7%(1/142) and 0%(0/142), respectively. Detected mutant allele of the CYP2D6(B) was heterozygous type(WM). The odds ratios for lung cancer susceptibility with CYP2D6(B) and CYP2D6(T) genotype were not calculated. These results are similar to the previous understanding that the mutant allele is very rare in Orientals compared to Caucasians, therefore, it considered that CYP2D6(B) and CYP2D6(T) genotypes have maybe no association with lung cancer susceptibility in Koreans. This is the basic data of CYP2D6(B) and CYP2D6(T) genotypes for Koreans. It would be hepful for further study to determine lung cancer susceptibility of Koreans with the data about CYP1A1, CYP2E1, GSTM1 from future study.
Adenocarcinoma
;
Alleles
;
Carcinoma
;
Carcinoma, Small Cell
;
Carcinoma, Squamous Cell
;
Cytochrome P-450 CYP1A1
;
Cytochrome P-450 CYP2D6
;
Cytochrome P-450 CYP2E1
;
Genotype
;
Healthy Volunteers
;
Lung Neoplasms*
;
Lung*
;
Odds Ratio
;
Polymerase Chain Reaction*
;
Polymorphism, Genetic
;
Polymorphism, Restriction Fragment Length