beta-receptor antagonist as antihypertensive agent has adverse effect such as vasoconstriction, bronchoconstriction and aggravation of atherosclerosis. So beta-receptor antagonist with alpha-receptor blocking property has been studied for avoidance of adverse effects of beta-receptor antagonist. Nipradilol, a new beta-receptor antagonist with alpha-receptor blocking property was administrated in 30 essential hypertensive patients for 10 week in order to evaluate the antihypertensive effects and adverse effects. The results were as follows: 1) Nipradilol was effective in 20 patients(67%) on systolic blood pressure 22 patients (73%) on diastolic blood pressure at the end of 10 weeks treatment. 2)Before medication, mean systolic and diastolic blood pressure in sitting position were 160+/-14mmHg and 102+/-18mmHg,and after 10 weeks of medication, mean systolic and diastolic blood pressure were significantly declined to 143+/-22mmHg and 89+/-12mmHg(p<0.001). 3) There was no significant change in pulse rate, from 78+/-12 beats per minute the beginning of the treatment to 75+/-11 beats per minute after 10 week of treatment. 4) There was no significant changes in sodium, potassium, GOT, GPT, bilirubin, alkalin ephosphatase, BUN, creatinine, LDH, CPK and lipid. 5) The adverse effects of nipradilol were bradycardia(7%), dyspnea(3%), chest discomfort(3%) and headache(3%). In summary, nipradilol seemed to be effective antihyertensive drug in treating mild to moderate hypertension.
Atherosclerosis ; Bilirubin ; Blood Pressure ; Bronchoconstriction ; Creatinine ; Heart Rate ; Humans ; Hypertension ; Potassium ; Sodium ; Thorax ; Vasoconstriction

No abstract available.
Leukemia*

A cross-sectional study of 118 car painters and controls of 113 workers was performed to investigate the interrelation between self-reported neuropsychiatric symptom and neurobehavioral performance using Scandinavian Questionnaire 16, Zung anxiety, depression scale and Swedish performance evaluation system (simple reaction time, symbol digit, digit span, finger tapping speed). The typical symptoms characteristic of painter's syndrome were not found and no significant association was found between solvent exposure and !total score of neuropsychiatric symptom but neurobehavioral performance of simple reaction time, symbol digit and digit span had association with solvent exposure. No significant associations were found between total score of neurotoxic symptom, anxiety scale, depression scale and the neurobehavioral performance. In factor analysis, the factor of questionnaire 16 measuring function of memory demonstrated no significant association with the factor of neurobehavioral test items measuring short term memory.
Anxiety ; Cross-Sectional Studies ; Depression ; Fingers ; Memory ; Questionnaires ; Reaction Time ; Solvents*

A clinical review was made on 48 cases with cor pulmonale who were admitted to medical department, National Medical Center, between 1973 and 1982, and the results were as follows : 1) Teh age of subjects ranged from 26 to 88, and their mean was 51. male to female ratio was 1.6:1 and majority of them were in their 6th and 7th decade. 2) COPD was the most common cause of cor pulmonale but pulmonary tuberculosis had also a considerable portion. Less commonly it was caused by chest deformity which was mainly from spine tuberculosis and kyphoscoliosis. 3) Almost all patients were admitted with over heart failure. 4) Laboratory features showed indirect evidence of heart failure and pulmonary hypertension in chest X-ray films, RVH patterns in EKG and hypoxia and hypertcapnea with metabolic compensation in arterial gas analysis. 5) The case fatality rate was one-forth and that from kyphoscoliosis was especially high(80%).
Anoxia ; Compensation and Redress ; Congenital Abnormalities ; Electrocardiography ; Female ; Heart Failure ; Humans ; Hypertension, Pulmonary ; Male ; Mortality ; Pulmonary Disease, Chronic Obstructive ; Pulmonary Heart Disease* ; Spine ; Thorax ; Tuberculosis ; Tuberculosis, Pulmonary ; X-Ray Film

Pulmonary Fibrosis*

No abstract available.

Pulmonary artery sling is an uncommon and potentially lethal vascular anomaly that can produce airway obstruction. Despite the availibility of a corrective operation, the mortality rate remains very high due to the high incidence of associated obstructive anomalies of the tracheobronchial tree. We experienced a 70-day-old male infant who was admitted to our unit because of sudden dyspnea, cyanosis, coarse expiratory wheezing and inspiratory stridor. At first, he was treated with bronchodilator and steroid under the impression of infantile asthma, but the symptoms went on without interval change. We performed magnetic resonance imaging study followed esophagography and two dimensional echocardiography. Finally he was diagnosed as a vascular sling. We report this with a brief review and related literatures.
Airway Obstruction ; Asthma ; Cyanosis ; Dyspnea ; Echocardiography ; Humans ; Incidence ; Infant ; Magnetic Resonance Imaging ; Male ; Mortality ; Pulmonary Artery ; Respiratory Sounds

No abstract available.
Endometrial Neoplasms* ; Female

The clinical life-time and the causes for the change of soft contact lens(SCL) were analyzed according to the sex, age and kinds of SCL. The clinical life-time(time interval of changing of the SCL) was 6.9 months on the average. In the clinical life-time and the causes for the change of SCL, there were no sexual difference and also no difference between plus and minus lenses(p>0.05). However, there were significant differences in them according to the age and kinds of SCL(p<0.05).In groups below 10 years old and over 60 years old, and in the extended SCL, loss rates were relatively high. This was thought to be related to shortening theclinical life-time of SCL.
Child ; Contact Lenses, Hydrophilic* ; Humans ; Middle Aged

PURPOSE: To evaluate the effects of threshold values, reconstruction interval, slice thickness and table speed on the spiral CT volumetry. MATERIALS AND METHODS: Two phantoms made of a balloon and diluted contrast media underwent spiral CT scanning with section thicknesses of 5, 7 and 10 mm and table speeds of 5, 8 and 10 mm with scans of 5 mm section thickness, 7, 10, and 14 mm with scans of 7 mm section thickness, and 10, 15, and 20 mm with scans of 10 mm section thickness. The volumetric values of phantom A and B were obtained at varying threshold values and a reconstruction interval of 5 and 10 mm for all scans. Volumes were also determined with the threshold value fixed and a reconstruction interval of 1, 5, 7 and 10 mm, respectively. Three-dimensional display and volumetric measurements were obtained using reconstructed images. The effects of threshold value, reconstruction interval, slice thickness and table speed on volumetry were analyzed. RESULTS: Volumetric values varied according to threshold values. Where a threshold value was low, value increased as pitch increased, but where a the threshold value was high, value decreased as pitch increased. With varying threshold values, measurement errors in hydrostatic volumetry were between 0.19 and 27.98%; at a fixed threshold value, measurement errors in CT volumetry were 1.6 to 9.0%. Volume decreased as reconstruc-tion interval increased. Where the table speed/ slice thickness ratio was constant, volume was constant though slice thickness differed. At fixed threshold values, variation in the reconstruction interval was statistically more significant than variation in slice thickness or table speed ( p<0.05, Kruskal-Wallis one-way ANOVA). CONCLUSION: Among serveral spiral scanning and image reconstruction parameters including threshold value, reconstruction interval, slice thickness, and table speed, threshold value most affected the result obtained. At fixed threshold values, the reconstruction interval usded had more effect on CT volumetry than other parameters.
Contrast Media ; Image Processing, Computer-Assisted ; Tomography, Spiral Computed*