1.Change of Serum IGF-I and IGFBP-3 Concentration During Induction Chemotherapy in Children with Acute Lymphocytic Leukemia.
Jee Yeon SONG ; Bin CHO ; Hak Ki KIM ; Byung Churl LEE
Journal of Korean Society of Pediatric Endocrinology 1997;2(1):53-59
PURPOSE:The most important regulatory factor for IGF-I and IGFBP-3 known so far GH and food intake. Poor nutrition in children with acute lymphocytic leukemia(ALL) increase morbidity during treatment. The aim of this study was to assess the changes of serum IGF-I and IGFBP-3 concentration during induction chemotherapy in 13 children with acute lymphocytic leukemia. METHODS:13 children aged between 1.6 and 13.5 years with ALL were studied the changes of serum IGF-I and IGFBP-3 concentration before, at 2 and 4 weeks after induction chemotherapy. Serum IGF-I and IGFBP-3 were measured using radioimmunoassay. Results : 1) Mean serum IGF-I and IGFBP-3 concentration before induction chemotherapy in ALL patient was significantly lower than the those of normal control(p<0.05). 2) Mean serum IGF-I and IGFBP-3 concentration at 2 weeks of induction chemotherapy were significantly higher than the those of the basal levels (p<0.05). 3) Mean serum IGF-I and IGFBP-3 concentration at 4 weeks after induction chemotherapy were significantly higher than the those of the basal levels (p<0.05). Conclusion : Concentration of serum IGF-I and IGFBP-3 in patients with ALL were significantly increased during induction chemotherapy. These results are probably related to improvement of nutritional status following induction chemotherapy.
Child*
;
Eating
;
Humans
;
Induction Chemotherapy*
;
Insulin-Like Growth Factor Binding Protein 3*
;
Insulin-Like Growth Factor I*
;
Nutritional Status
;
Precursor Cell Lymphoblastic Leukemia-Lymphoma*
;
Radioimmunoassay
2.Roentgenorams of the Chest in Acute Glomeruloneptritig in Children.
Sung Churl PARK ; Su Yung KIM ; Hak Soo LEE
Journal of the Korean Pediatric Society 1980;23(11):935-939
Roentgenograms of the chest were reviewed from 122 childrens with acute glomeruloneph ritis. Abnormalities were found in 110 roentgenograms. These included cardiomegaly in 82(67.2%), prominent pulmonary vasculature in 98(80.3%), pleural effusion in 35(28.6%), pulmonary edema in 24(19.6%), and pulmonary consolidation in 20(16.3%). The roentgen findings in the chest, although not pathognomic, may have diagnostic values occasionally.
Cardiomegaly
;
Child*
;
Humans
;
Pleural Effusion
;
Pulmonary Edema
;
Thorax*
3.Periodontal treatment of a Glanzmann's thrombasthenia patient: A case report.
Hak Churl LEE ; Soo Boo HAN ; Woo Sung KIM ; Hye Ja LEE
The Journal of the Korean Academy of Periodontology 1997;27(3):597-602
Glanzmann's thrombasthenia is a qualitative platelet disorder characterized by a deficiency in the platelet membrane glycoproteins IIb/IIIa. It belongs to a group of hereditary platelet disorders typified by normal platelet numbers and a prolonged bleeding time. The severity of bleeding does not correlate with the severity of the platelet glycoprotein IIb/IIIa abnormality. The present case report describes the periodontal treatment of a patient with Glanzmann's thrombasthenia. A 30-year-old female with a history of Glanzmann's thrombasthenia was referred for gingival bleeding on tooth brushing and discomforts in #38 area. The periodontal finding revealed a diagnosis of localized slight adult periodontitis. Root planing and extraction of #38 was performed under 12 pack of platelets transfusion and digital compression was done for hemostasis. The gingival bleeding ceased within a day in maxilla and 2 days later in mandible. 42 pack of platelets was administered for 3 days of post-treatment and for iron-deficiency anemia 3 pack of RBCs was transfused 2 days later. 1 week later the inflammation in gingiva disappeared and gingival stippling appeared. The clinical result we got was good and in such a medically compromised patient it is an ability to maintain a proper oral hygiene that is essential both for oral and systemic health.
Adult
;
Anemia, Iron-Deficiency
;
Bleeding Time
;
Blood Platelet Disorders
;
Blood Platelets
;
Chronic Periodontitis
;
Diagnosis
;
Female
;
Gingiva
;
Glycoproteins
;
Hemorrhage
;
Hemostasis
;
Humans
;
Inflammation
;
Mandible
;
Maxilla
;
Oral Hygiene
;
Platelet Count
;
Platelet Membrane Glycoproteins
;
Root Planing
;
Thrombasthenia*
;
Tooth
4.Treatment of Tibial Pilon Fractures using Ring Fixators and Arthroscopy
Hak Sun KIM ; Jun Seop JAHNG ; Sang Soo KIM ; Churl Hong CHUN ; Hong Jun HAN ; Sung Ho LEE
The Journal of the Korean Orthopaedic Association 1995;30(5):1538-1545
There were 21 cases of tibial pilon fractures in total: type I-2 cases, type II-14 cases, type III-5 cases according to Rued's classification. In type I and II, ring fixators were applied to tibia and foot and closed reduction was performed monitoring the quality of the reduction with an image intensifier. When the quality of the reduction was questionable, we rechecked it using arthroscopy and if neces- sary, the reduction was readjusted. Instead of using plate and screws, we used olive stop wires to achieve stable fixation. In type III, a limited open reduction was performed in the place of arthroscopy. Approximately at the eighth week after operation, we removed the fixation of calcaneus, metatarsal and foot mounting. Between 16 and 28 weeks, we removed the foot mounting after achieving bony union in all cases except one case(20 cases). In the follow-up cases of 2 years and more, we obtained the fine functional results of 15 good, 4 fair and 2 poor cases. Fewer major complications were observed except 8 cases of pin tract infection(grade 1) and 1 case of reduction loss. Using ring fixators and arthroscopy, we had fewer surgical complications.
Arthroscopy
;
Calcaneus
;
Classification
;
Follow-Up Studies
;
Foot
;
Metatarsal Bones
;
Olea
;
Tibia
5.Change of plaque removal ability by worn toothbrush.
Hak Churl LEE ; Byung Kun YANG ; Chul Woo LEE ; Yong Moo LEE ; In Chul RHYU ; Chong Pyung CHUNG ; Soo Boo HAN
The Journal of the Korean Academy of Periodontology 2004;34(1):61-70
No abstract available.
6.Femoral Neuropathy Subsequent to Abdominal Hysterectomy.
Ji Wook JEONG ; Ji Kwon PARK ; Hyon Churl CHO ; Won Jun CHOI ; Soon Ae LEE ; Jong Hak LEE ; Won Young PAIK
Korean Journal of Gynecologic Oncology and Colposcopy 2001;12(1):3-11
OBJECTIVE: To evaluate the clinical factors that contribute to femoral neuropathy subsequent to abdominal hysterectomy. METHODS: From March 1993 to March 2000, retrospective study on 17 cases of femoral neuropathy subsequent to abdominal hysterectomy was performed. Sixty eight patients who had normal neurologic finding on the lower extremities after the same operation were used as a control group. RESULTS: The incidence of femoral neuropathy subsequent to abdominal hysterectomy was 1.67%. Age, body weight, parity and type of skin incision were significantly different between study and control group. The mean age of the study group was 38.1+6.1 years and that of the control group was 43.2+/-8.9 years(p<0.05). The mean body weight of the study group was 52.9 6.4kg, while that of the control group was 57.8+/-7.4kg(p<0.05). The mean parity of the study group was 1.9+/-0.7 as opposed to 2.6+/-1.3 for the control group(p<0.05). Pfannenstiel`s incision was performed in 13 cases(76.5%) in the study group as opposed to 34 cases(50%) in the control group(p<0.05). There were no correlation between these two groups with respect to patient height, operative time, transfusion and change in hemoglobin level. In the study group, 13 cases(76.5%) with femoral neuropathy on the left side were found, 3 cases(17.6%) on the right side and 1 case(5.9%) on both side. Left side femoral neuropathy was more common than the right(p<0.05). Spontaneous recovery occurred in 16 cases of the study group within 4 months and, although residual symptoms were noted in the remaining 1 case, no serious sequelae have been observed. CONCLUSION: It was suggested that pelvic retractor compresses the femoral nerve during the abdominal hysterectomy. The patients age, body weight, parity and a type of skin incision could be contributing factors to femoral neuropathy.
Body Weight
;
Female
;
Femoral Nerve
;
Femoral Neuropathy*
;
Humans
;
Hysterectomy*
;
Incidence
;
Lower Extremity
;
Neurologic Manifestations
;
Operative Time
;
Parity
;
Retrospective Studies
;
Skin
7.The Effect of Bioresorbable Membrane on the Bone Regeneration of Streptozotocin Induced Diabetic Rats.
Byung Kun YANG ; Hak Churl LEE ; Ji Young LEE ; Kang Bae SON ; Yang Jo SEOL ; Sang Cheol LEE ; Seung Beom KYE ; Chong Pyoung CHUNG ; Soo Boo HAN
The Journal of the Korean Academy of Periodontology 2000;30(2):287-303
The purpose of this study is to evaluate the effects of bioresorbable membranes in guided bone regeneration of streptozotocin induced diabetic rats. 50 Sprague-Dawley rats were randomly categorized into 4 groups: Group 1 & 2 had 10 normal rats each and group 3 & 4 included 15 streptozotocin induced diabetic rats each. Defect measuring 7mm in diameter was formed on every rat calvarium. No membrane was used in groups 1 & 3 and membranes were used in groups 2 & 4. The rates were sacrificed at 2 and 4 weeks after defect formation. Routine histological specimens were prepared. Masson-trichrome and HE stain were done before light microscopy. Guided regenerative potential was evaluated by measuring the amount of new bone formation in the calvarial defect by histomorphometry. Following results were obtained. 1.New bone formation in the diabetic groups was significantly less that than in the normal groups regardless of membrane use(p <0.05). 2.In the comparison of new bone formation in the normal groups, membrane group showed significantly more bone formation(p <0.1). 3.When the amount of new bone formation was compared in the diabetic groups, more bone was formed in the membrane groups but the difference was not statistically significant. 4.In the normal groups the amount of new bone formation was significantly greater at 4 weeks compared to that at 2 weeks(p <0.05) but amount of bone regeneration at 4 weeks was not significantly greater than that at 2 weeks in both diabetic groups.
Animals
;
Bone Regeneration*
;
Diabetes Mellitus
;
Membranes*
;
Microscopy
;
Osteogenesis
;
Rats*
;
Rats, Sprague-Dawley
;
Skull
;
Streptozocin*
8.Arterial Thoracic Outlet Syndrome: A Case Report.
Churl Bum LEE ; Shee Yeung HAHM ; Won Sang JUNG ; Young Hak KIM ; Jung Ho KANG ; Hong Gee LEE ; Choong Gee PARK
The Korean Journal of Thoracic and Cardiovascular Surgery 1998;31(9):903-906
A 17-year-old-boy with a bilateral incomplete cervical rib, upon abduction of his left arm at 45 degrees, had immediately begun to show symptoms of severe tingling, claudication, pallor, and weakness of his left upper extremity. These symptoms were aggravated at 90 degrees, leaving him debilitated from his work in the printing office. Transfemoral positional subclavian arteriography revealed total occlusion of the subclavian artery immediately distal to a cervical rib during 90 degrees abduction. Resection of the anterior scalene and medial aspect of the middle scalene muscles, cervical and first ribs, and arteriolysis were performed via a combined supraclavicular and infraclavi cular approach. He has returned to work as a printer with marked relief of symptoms and has remained asymptomatic over follow-up periods of 10 months.
Angiography
;
Arm
;
Cervical Rib
;
Follow-Up Studies
;
Muscles
;
Pallor
;
Ribs
;
Subclavian Artery
;
Thoracic Outlet Syndrome*
;
Upper Extremity
9.Treatment of Class II Furcation Involvements in Humans with Bioabsorbable Guided Tissue Regeneration Barriers.
Hak Churl LEE ; Seoung Min HAN ; Yang Jo SEOL ; Chul Woo LEE ; Heung Sik UM ; Beom Suk CHANG ; Chong Pyoung CHUNG ; Soo Boo HAN
The Journal of the Korean Academy of Periodontology 1999;29(3):539-551
The purpose of this 6-months study was to compare the clinical and radiographic outcomes following guided tissue regeneration treating human mandibular Class II furcation defects with a bioabsorbable BioMesh barrier(test treatment) or a non-absorbable ePTFE barrier(control treatment). Fourteen defects in 14 patients(mean age 44 years) were treated with BioMesh barriers and ten defects in 10 patients(mean age 48 years) with ePTFE barriers. After initial therapy, a GTR procedure was done. Following flap elevation, root planing, and removal of granulation tissue, each device was adjusted to cover the furcation defect. The flaps were repositioned and sutured to complete coverage of the barriers. A second surgical procedure was performed at control sites after 4 to 6 weeks to remove the nonresorbable barrier. Radiographic and clinical examinations(plaque index, gingival index, tooth mobility, gingival margin position, pocket depth, clinical attachment level) were carried out under standardized conditions immediately before and 6 months after surgery. Furthermore, digital subtraction radiography was carried out. All areas healed uneventfully. Surgical treatment resulted in clinically and statistically equivalent changes when comparisons were made between test and control treatments. Changes in plaque index were 0.7 for test and 0.4 for control treatments; changes in gingival index were 0.9 and 0.5. In both group gingival margin position and pocket depth reduction was 1.0mm and 3.0mm; clinical attachment level gain was 1.9mm. There were no changes in tooth mobility and the bone in radiographic evaluation. No significant(p< or =0.05) difference between the two membranes could be detected with regard to plaque index, gingival index, gingival margin position, pocket depth, and clinical attachment level. In conclusion, a bioabsorbable BioMesh membrane is effective in human mandibular Class II furcation defects and a longer period study is needed to fully evaluate the outcomes.
Furcation Defects
;
Granulation Tissue
;
Guided Tissue Regeneration*
;
Humans*
;
Membranes
;
Periodontal Index
;
Radiography
;
Root Planing
;
Tooth Mobility
10.Puberty and Gonadal Function after Bone Marrow Transplantation During Childhood.
Kyung Hwa HA ; Min Ho JUNG ; Nak Gyun CHUNG ; Bin CHO ; Byung Kyu SUH ; Hak Ki KIM ; Byung Churl LEE
Journal of Korean Society of Pediatric Endocrinology 2006;11(2):148-154
PURPOSE: Bone marrow transplantation (BMT) involving high dose chemotherapy and irradiation can seriously affect the gonad and reproductive axis. We studied puberty and gonadal function in the subjects who underwent BMT during childhood for the treatment of acute leukemia. METHODS: 25 females (age at examination:15.7+/-3.1 years; age at BMT:10.3+/-3.0 years) and 22 males (age at examination:16.4+/-2.0 years; age at BMT:11.1+/-2.2 years) who underwent BMT for acute leukemia were included. We evaluated their pubertal status and gonadal function before and after BMT, and investigated the clinical factors influencing disturbances of gonadal function in these patients. RESULTS: Of the 13 females who were prepubertal before BMT, two had no breast development by 13 years of age, and the others entered puberty spontaneously. Of the 8 females who were older than 16 years at the last evaluation, 5 had primary amenorrhea, and 3 developed secondary amenorrhea. Sixteen (64.0%) out of 25 pubertal females had abnormally elevated serum concentrations of luteinizing hormone (LH), and 23 (92.0%) had abnormally elevated serum concentrations of follicle-stimulating hormone (FSH). Abnormal elevation of LH was more frequent in the females who had entered puberty at BMT compared with those before puberty (91.7% vs 45.5%, OR=13.2, P<0.05). Of the 19 males who were prepubertal before BMT, 3 did not enter puberty spontaneously by 14 years of age, and the others entered puberty spontaneously. Four (18.2%) out of 22 pubertal males had abnormally elevated plasma concentrations of LH, and 9 (42.9%) had abnormally elevated plasma concentrations of FSH. Abnormal elevation of FSH was more frequent in males who underwent BMT after relapse than those without relapse (87.5% vs 20.0%, OR=28.0; P<0.05). CONCLUSION: More than 40% of the girls who underwent BMT cannot retain adequate ovarian function to complete puberty and menstruate regularly. The ovaries of the pubertal girls seem to be more vulnerable to BMT. The majority of the boys experience normal pubertal development after BMT, but about 40% of the boys had abnormally elevated levels of FSH, which is indicative of germ cell dysfunction.
Adolescent
;
Amenorrhea
;
Axis, Cervical Vertebra
;
Bone Marrow Transplantation*
;
Bone Marrow*
;
Breast
;
Drug Therapy
;
Female
;
Follicle Stimulating Hormone
;
Germ Cells
;
Gonads*
;
Humans
;
Leukemia
;
Luteinizing Hormone
;
Male
;
Ovary
;
Plasma
;
Puberty*
;
Recurrence