1.Alterations in antibacterial activity of amniotic fluid by meconium.
Kwon Il NOH ; Pyl Ryang LEE ; Seung Cheol KIM ; Hak Soon KIM
Korean Journal of Perinatology 1993;4(2):206-214
No abstract available.
Amniotic Fluid*
;
Female
;
Meconium*
2.Free Fillet Flap of the Forearm Amputee for Coverage of the Contralateral below Elbow Amputee and Restoration of the Flexion of the Elbow.
Soo Joong CHOI ; Bong Cheol KWON ; Kyu Hak JUNG
Journal of the Korean Microsurgical Society 2007;16(2):82-85
Free vascularized tissue transfer to preserve upper extremity amputation level is uncommon but very useful procedure. To cover the below-elbow amputee stump and restore the function of the elbow, we have used a free flap as a spare part concept from the contralateral hand which was so severely damaged that amputation was inevitable.
Amputation
;
Amputees*
;
Elbow*
;
Forearm*
;
Free Tissue Flaps
;
Hand
;
Humans
;
Upper Extremity
3.Pars Interarticularis Injections in a Patient with Spondylolysis: A case report.
Sang Cheol PARK ; Joon Byum PARK ; Young Eun KWON ; Jun Hak LEE
The Korean Journal of Pain 2005;18(2):251-254
Spondylolysis, also known as stress injury of pars interarticularis, is a common cause of back pain in athletes, particularly children and young adults. Repeated minor traumas during flexion and extension of the spine are thought to result in bony failure due to excessive bone resorption. These lesions are common in the low back, with the majority found at the L5 vertebra. In the majority of cases of spondylolysis, non-operative treatments are recommended, such as NSAIDs, physiotherapy and bracing. Only if symptoms do not respond to conservative treatments should surgical intervention be considered. Recently, pars interarticularis injections for diagnostic and therapeutic purposes have been found to allow significant pain relief from spondylolysis for long periods. Here, the case of a 57-year-old man with spondylolysis, who suffered from back pain, which was not relieved by an epidural steroid injection, but in whom pars interarticularis injections of local anesthetic and steroid induced complete transient pain relief, following by moderate long-term relief, is presented.
Anti-Inflammatory Agents, Non-Steroidal
;
Athletes
;
Back Pain
;
Bone Resorption
;
Braces
;
Child
;
Humans
;
Middle Aged
;
Spine
;
Spondylolysis*
;
Young Adult
4.Performance Evaluation of the Syva EMIT Methotrexate Assay on the Toshiba 200FR NEO.
Jinsook LIM ; Jimyung KIM ; Yong Hak SOHN ; Sun Hoe KOO ; Gye Cheol KWON
Laboratory Medicine Online 2014;4(4):187-190
BACKGROUND: Methotrexate (MTX) is an antifolate antagonist that is widely used for treating various malignancies and non-malignant diseases. MTX levels should be monitored when used in high concentration to determine when to start leucovorin rescue. In this study, we evaluated the analytical performance of the EMIT Methotrexate Assay on a 200FR NEO Chemistry Analyzer (Toshiba Medical System Co., Japan) and compared it with Viva-E Drug Testing System (Siemens Healthcare, Germany). METHODS: According to the Clinical Laboratory and Standards Institute (CLSI) Evaluation Protocol (EP) 5-A2, three concentrations of the Liquichek Therapeutic Drug Monitoring Control (Bio-Rad Laboratories, USA) were analyzed twice a day for 20 days to monitor assay precision. The 200FR NEO and Viva-E instruments were compared using 40 patients' sera, according to CLSI EP9-A2. The linearity and carry-over rate were also evaluated. RESULTS: Between-run CVs for low-, medium-, and high-level controls were 4.9%, 0.9%, and 2.0%, respectively, whereas between-day CVs for low-, medium-, and high-level controls were 8.1%, 1.3%, and 3.5%, respectively. In the linearity test, the coefficient of determination (R2) was 0.98 (0.06-1.92 micromol/L). In the comparison study, R2 was 0.955, showing good correlation between the 200FR NEO and Viva-E instruments. The carry-over rate was 0.9%. CONCLUSIONS: The EMIT assay showed good precision, linearity, and carry-over rate on the Toshiba 200FR. An excellent correlation was observed when comparing results obtained using the Toshiba and Viva-E instruments. In conclusion, the Syva EMIT MTX assay can be readily used for MTX monitoring on the Toshiba 200FR NEO.
Chemistry
;
Delivery of Health Care
;
Drug Monitoring
;
Leucovorin
;
Methotrexate*
5.Long Term Outcomes of Gamma Knife Radiosurgery for Typical Trigeminal Neuralgia-Minimum 5-Year Follow-Up.
Jong Kwon LEE ; Hyuk Jai CHOI ; Hak Cheol KO ; Seok Keun CHOI ; Young Jin LIM
Journal of Korean Neurosurgical Society 2012;51(5):276-280
OBJECTIVE: Gamma knife radiosurgery (GKRS) is the least invasive surgical option for patients with trigeminal neuralgia (TN). However, the indications and long term outcomes of GKRS are still controversial. Additionally, a series with uniform long-term follow-up data for all patients has been lacking. In the present study, the authors analyzed long-term outcomes in a series of patients with TN who underwent a single GKRS treatment followed by a minimum follow-up of 60 months. METHODS: From 1994 to 2009, 40 consecutive patients with typical, intractable TN received GKRS. Among these, 22 patients were followed for >60 months. The mean maximum radiation dose was 77.1 Gy (65.2-83.6 Gy), and the 4 mm collimator was used to target the radiation to the root entry zone. RESULTS: The mean age was 61.5 years (25-84 years). The mean follow-up period was 92.2 months (60-144 months). According to the pain intensity scale in the last follow-up, 6 cases were grades I-II (pain-free with or without medication; 27.3%) and 7 cases were grade IV-V (<50% pain relief with medication or no pain relief; 31.8%). There was 1 case (facial dysesthesia) with post-operative complications (4.54%). CONCLUSION: The long-term results of GKRS for TN are not as satisfactory as those of microvascular decompression and other conventional modalities, but GKRS is a safe, effective and minimally invasive technique which might be considered a first-line therapy for a limited group of patients for whom a more invasive kind of treatment is unsuitable.
Follow-Up Studies
;
Humans
;
Microvascular Decompression Surgery
;
Radiosurgery
;
Trigeminal Neuralgia
6.Chest Pain due to Rapidly Developed Metastatic Spinal Tumor : A case report.
Jun Hak LEE ; Hyung Tae KIM ; Cheol Sin MUN ; Hyeon Eon HEO ; Young Eun KWON
Korean Journal of Hospice and Palliative Care 2009;12(2):88-94
Chest pain is a symptom observed commonly in outpatients and emergency room patients, and its causes are variable. Because treatment and prognosis of chest pain are different depending on its cause, it is more important than anything else to accurately diagnose the cause of chest pain. Most of patients complaining of chest pain undergo basic tests at a private local clinic or at the Internal medicine or chest surgery department of a general hospital and, they are referred to the pain clinic, with a note stating no particular finding. However, if they have sustained severe neuropathic pain in spite of nerve block, accurate diagnosis for chest pain is essential. We experienced rapidly developing spine breakdown and cord compression caused by metastatic spinal tumor in an inpatient who was being treated for chest pain, and thus, we report here in the case with literature review.
Chest Pain
;
Emergencies
;
Hospitals, General
;
Humans
;
Inpatients
;
Internal Medicine
;
Nerve Block
;
Neuralgia
;
Outpatients
;
Pain Clinics
;
Prognosis
;
Spine
;
Thorax
7.Concomitant ultrasound-guided intra-gestational sac methotrexate-potassium chloride and systemic methotrexate injection in the recurrent cesarean scar pregnancy.
Ju Hak LEE ; Dae Hui KWON ; Ki Hoon AHN ; Soon Cheol HONG ; Tak KIM
Obstetrics & Gynecology Science 2016;59(3):245-248
Recurrent ectopic pregnancy of cesarean scar is very rare and its therapeutic management is still not established. We reported the first case of recurrent cesarean scar pregnancy that was successfully treated with concomitant intra-gestational sac methotrexate-potassium chloride injection and systemic methotrexate injection. This case study provides physicians with a safe and effective minimally invasive treatment option for recurrent cesarean scar pregnancy.
Cicatrix*
;
Female
;
Methotrexate*
;
Potassium Chloride
;
Pregnancy*
;
Pregnancy, Ectopic
8.Detection of HPV in cervical scrape specimens of cervical neoplasia using the polymerase chain reaction.
Seung Chul KIM ; Hak soon KIM ; Ju Cheol SONG ; Seo Ok KANG ; Young Bum CHA ; In Kwon HAN ; In Geol MOON ; Won Hee HAN ; Chong Taek PARK
Korean Journal of Obstetrics and Gynecology 1992;35(9):1269-1279
No abstract available.
Polymerase Chain Reaction*
9.Radiation Therapy (RT) of Midline Granuloma.
Hyoung Cheol KWON ; Yoon Kyeong OH ; Hak Jun GIL ; Sei Chul YOON ; Yong Whee BAHK
Journal of the Korean Society for Therapeutic Radiology 1986;4(2):135-140
Seven patients having midline granuloma received local irradiation from March 1983 to June 1986. Clinically, all of the 7 patients had pansinusitis with necrotic destruction of the involved sites and one case revealed colonic lesion. Each of the patients received a tumor dose of 4,000 ~ 5,000 cGy/5~6wks to the upper aerodingestive tract using a 6-MV linear accelerator. Complete and partial remission occurred in 3 patients each, and in one case, the disease progressed despite of the irradiation.
Colon
;
Granuloma*
;
Humans
;
Particle Accelerators
10.A Clinical Profile of Peripheral Neuropathy in Korean Children.
Hwan Seok LEE ; Woo Saeng PARK ; Cheol Woo KO ; Yoon Kyung SOHN ; Soon Hak KWON
Journal of the Korean Child Neurology Society 2003;11(1):128-134
PURPOSE: To analyze the clinical features of peripheral neuropathy in Korean children. METHODS: A total of 62 children with acute flaccid paralysis, longstanding weakness of extremities, or abnormal electrophysiological studies, suggestive of peripheral neuropathy, were evaluated retrospectively from the hospital records. The subjects were recruited at the pediatric neurology and endocrine clinic, Kyungpook National University Hospital from 2000 to 2002 and they all went through neurological examination and electrophysiological studies with or without nerve biopsy. RESULTS: Thirty nine children(Male 24:Female 15; Mean age 7.6+/-4.3 years) were found to have clinical peripheral neuropathy. Inflammatory neuropathy(5 children with Guillain Barre syndrome, 1 children with chronic inflammatory demyelinating polyneuropathy, 12 children with Bell's palsy; 46%) was the most common, followed by hereditary neuropathy(4 children, 10%), Chemotherapy induced neuropathy(3 children, 8%), metachromatic leukodystrophy(2 children, 5%), trauma(2 children, 5%), diabetic neuropathy(1 children, 3%) and so on. Thirty two children had motor neuropathy(82%), six children had combined motor and sensory neuropathy(15%), two had pure sensory(5%), but nobody had autonomic neuropathy. With respect to the type of involvement, polyneuropathies constitute 59%(23 children), mononeuropathy simplex accounted for 38%(15 children), mononeuropathy multiplex was found in 3%(1 child). Based on electrophysiological studies and biopsy results, demyelinating neuropathy was seen in 22 children(56%), axonal neuropathy in 12 children(31%), combined neuropathy in 5 children(13%). Eighteen children(46%) were completely or almost completely recovered from the illness. CONCLUSION: Inflammatory neuropathy was the most common among the acquired neuropathies and hereditary motor sensory neuropathy was the most common among the genetic neuropathies. Treatable neuropathies took up 46%. Potentially preventable neuropathies accounted for 36%. Early diagnosis and early intervention may have significant impacts on the prognosis of peripheral neuropathy in children.
Axons
;
Bell Palsy
;
Biopsy
;
Child*
;
Drug Therapy
;
Early Diagnosis
;
Early Intervention (Education)
;
Extremities
;
Guillain-Barre Syndrome
;
Gyeongsangbuk-do
;
Hospital Records
;
Humans
;
Mononeuropathies
;
Neurologic Examination
;
Neurology
;
Paralysis
;
Peripheral Nervous System Diseases*
;
Polyneuropathies
;
Prognosis
;
Retrospective Studies