No abstract available.
Induction Chemotherapy* ; Uterine Cervical Neoplasms*

No abstract available.
Gestational Trophoblastic Disease*

No abstract available.
Epidermolysis Bullosa Dystrophica* ; Epidermolysis Bullosa*

An experimental study was performed to investigate. The subjects drank 0.5g/kg ethanol and performed 7 items of SPES(simple reaction time, color word stress, digit classification, finger tapping speed, numerical ability, symbol digit coding, memory digit span). 20 students of medical college participated in the study during August, 1996. After ethanol intake, performance of 4 items(simple reaction time, digit classification, finger tapping speed, symbol digit coding) significantly showed to be decreased. The function of perception - response speed and steady movement were found to be more sensitive to ethanol than that of short - term memory, numerical ability and specification of color. No significant association were found between smoking, alcohol drinking, BMI(body mass index) and the effects of ethanol on neurobehavioral performance.

No abstract available.
Cyclic GMP* ; Cytomegalovirus* ; Gene Expression* ; Humans*

In a conservative treatment of lumbar disc herniation, authors customarily had included the flexion exercise untill 1991. Thereafter, the extension exercise started to be included for the selected patients and this study was designed to assess the clinical outcome of the extension exercise compared to the flexion exercise in the conservative treatments of lumbar disc herniations. 55 consecutive patients (31 males and 24 females having ages ranging from 19-68 years with a mean of 37.2) were included in this prospective study. Criteria for inclusion in this group were: 1. Contained herniations of a single lumbar disc, documented by CT or MRI; 2. no other concurrent spine pathology; 3. conservative treatments with an uniform program including the extension exercise; 4. follow-up for a minimum of one year. For comparison with this prospective group, another 62 consecutive patients (36 males and 26 females having ages ranging from 17-63 years with a mean of 35.7) were selected who were treated during 1991 with flexion exercise before this study was designed and who were matched with the designed criteria except for the direction of exercise. Apart from the therapeutic exercise, the conservative treatments also included medication, physiotheraphy, epidural injection, and back school in the both groups uniformly. The clinical outcome of the extension exercise group indicated that 28 (50.9%) patients excellent, 23 (41.8%) patients good, three (5.5%) patients fair, and one (1.8%) patient failed outcomes. In the flexion exercise group, there were 23 (37.1%) excellent, 27 (43.5%) good, seven (11.3%) fair, and five (8.1%) failed outcomes. From these results, it would seem to follow that the extension exercise group had superior clinical outcome compared to the flexion exercise, i.e. higher excellent and good outcomes (92.7% vs. 80.6%) and lower poor and failed outcomes (7.3% vs. 19.4%), respectively, Moreover, the excellent outcome in terms of full recovery without any pain and disability was more common in the extension exercise group (50.9% vs. 37.1%). A better clinical outcome was obtained in the extension exercise group of patients who were younger than 40 years and who had a history of three months or less compared with those who were older and had longer history of disease. The sizes of disc protrusion did not affect the clinical outcome. In conclusion, we would recommend that the extension exercise, instead of the flexion exercise, should be included in the conservative treatment of a contained herniation of lumbar disc for a better clinical outcome.
Female ; Follow-Up Studies ; Humans ; Injections, Epidural ; Magnetic Resonance Imaging ; Male ; Pathology ; Prospective Studies ; Spine

No Abstract Available.
Arthroplasty* ; Knee*

No abstract available.
Amikacin* ; Cefuroxime* ; Hysterectomy* ; Sodium*

Fibrin glue(FG) has been successfully used in a wide range of surgical fields such as skin graft fixation, nerve repair, cartilage reattachment and microvascular anastomoses. The sustained release of antibiotics from FG for a longer period is desirable to avoid bacterial infection after application. Furthermore, this is indispensible for FG so as to be used as a local antibiotic carrier. Ampicillin sodium(AMP-Na) was selected as a model antibiotic and incorporated into FG. In an attempt to achieve sustained release of it, the incorporation of AMP-Na into FG was tried in two different ways. One was incorporation of AMP-Na in a dispersed state with the modification of the preparation method of FG. The other was incorporation of bovine serum albumin microspheres(BSA-MS) containing AMP-Na. The in vitro release of AMP-Na from various FG was examined. The modifications of FG were found not to be appropriate methods to achieve sustained release of AMP-Na. However, the incorporation of crosslinked BSA-MS containing AMP-Na into FG was found to reduce the initial rapid release of AMP-Na and retared the release of AMP-Na ; t0.9 was 33 hours. The prophylactic efficacy of antibiotic-loaded FG against pathogenic bacteria was evaluated by artificially induced abscess model in the rabbit. The abscess model in the rabbit was induced by inoculation of pathogenic bacteria(synchronized culture of Staphylococcus aureus). Three different experimental group of pathogenic bacteria was injected into oral mucosa of the rabbit and hisopathological assessment was examined to evaluated the prophylatic efficacy of antibiotic-loaded FG. In pathogen only group, large pus pocket was formed after only 24 hours. However, the abscess diameter of the combination group(i.e.,pathogen and AMP-Na loaded FG) showed much smaller than of pathogen only group. Histopathological study also showed that there was the least inflammatory cell in the combination group of pathogen and BSA-MS loaded FG among the three experimental group tested. These results indicate that antibiotic-loaded FG has not only the prophylactic efficacy against post-operative infection, but also has the potential to be employed as a local biodegradable antibiotic carrier.
Abscess ; Ampicillin ; Anti-Bacterial Agents ; Bacteria ; Bacterial Infections ; Cartilage ; Fibrin Tissue Adhesive* ; Fibrin* ; Mouth Mucosa ; Serum Albumin, Bovine ; Skin ; Staphylococcus ; Suppuration ; Transplants

A man with bilateral primitive persistent trigeminal artery combined with cerebral rete mirabile is reported. Direct both common carotid artery angiogram is described with a brief discussion of the embryogenesis of carotid-basilar anastomosis and cerebral rete mirabile. Associated findings of previously reported cases of persistent trigeminal artery and cerebral rete mirabile are briefly reviewed. Persistent of the bilateral trigeminal artery associated with hemorrhage from cerebral rete mirabile seems worthy of notation. The angiographic findings were as follows; 1) The characteristic angiographic findings are bilateral occlusion at the cavernous portion of internal carotid artery. 2) Retrograde filling of middle cerebral artery from the collateral anastomotic channel was showed. 3) Anterior and posterior cerebral arteries are filled from leptomeningeal anastomotic channel and cerebral rete anastomosis. Authors suggested that the persistent trigeminal artery is congenital origin and cerebral rete mirabile may suspect to the secondary change.
Arteries* ; Carotid Artery, Common ; Carotid Artery, Internal ; Embryonic Development ; Female ; Hemorrhage ; Middle Cerebral Artery ; Posterior Cerebral Artery ; Pregnancy