Objective To evaluate the efficacy and safety of bortezomib combined with dexamethasone and thalidomide in the treatment of autologous stem cell transplantation ( ASCT) in multiple myeloma ( MM) . Methods The randomized con-trolled trials ( RCTs) on combined therapy with bortezomib,dexamethasone and thalidomide for ASCT in MM were retrieved from Pubmed,Medline,the Cochrane Library,CNKI,VIP and Wanfang databases (published until December 2014).The method of the Cochrane systematic review was used to evaluate the quality of the included RCTs and the Review Manager 5.3.5 software was em-ployed for Meta-analysis. Results Five RCTs involving 1 271 patients were included.The meta analysis results showed that the complete remission ( CR) rate,near-CR rate and total effective rate were significantly higher after combined treatment with borte-zomib,dexamethasone and thalidomide when compared with those in other combination therapies [CR+nCR, RR=1.50,95%CI (1.16,1.94),P=0.002;the total effective rate,RR=1.13,95%CI (1.03,1.24),P=0.009].In terms of safety,the grade 3/4 ad-verse events were significantly increased in the group of combined therapy with bortezomib,dexamethasone and thalidomide [ RR=1.29,95%CI (1.05,1.59),P=0.02]. Conclusion Bortezomib combined with thalidomide and dexamethasone for the treat-ment of ASCT in MM can significantly improve the CR+nCR and the total effective rate,but it also increases the incidence of the overall adverse events at the same time.

The paper is to explore the goals and models of Orthodontic teaching in eight-year medical students. It tries to design some teaching goals, teaching models and standards of examination to train medical students according to the eight-year program characteristics, and discuss the problems of eight-year program orthodontic teaching.

Objective:To analyze the association between obesity and age at spermarche among Chinese Han boys aged 11-18 years . Methods:The height, weight and status of the spermarche of Chinese Han boys aged 11-18 years were selected from the data of 2010 National Physical Fitness and Health Surveil-lance. The body mass index ( BMI) , prevalence of spermarche in each age group and ages at spermarche by BMI groups were calculated. Chi square test was used to analyze the differences of prevalences of spermarche among the boys with different BMIs across ages. U-test was used to compare the differences of age at spermarche between the boys who were obese and not. Results:In the boys aged 12 and 17 years in urban areas and boys aged 13 years in rural areas, the differences of prevalences of spermarche among the normal weight, overweight and obesity groups were significant (P<0. 05). The age at spermarche in the obesity group (13. 90 years) was 0. 1 years earlier than that in the non-obesity group (14. 00 years) (P<0. 05). Conclusion:Obesity may make the age at spermarche ahead of time.

Objective:To study the effects of treatment of Angle Ⅱ division 2 malocclusion with upper/lower arch expansion and Class Ⅱ elastics in adults. Methods:Expanding upper/lower arch and Class Ⅱ elastic were used to treat Angle Class Ⅱ division 2 malocclusion in 15 adults. Study models and cephalograms were analyzed before and after treatment. Results:Before and after treatment the maxillary variables of cephalograms showed no significant differences, the mandibular variables showed significant differences in sagittal and vertical direction. U1-NA, U1-PP, L1-NB, L1-MP, U1-L1 and L6-Ptm were significantly increased after treatment(P

Drug metabolism determines several pharmacological and toxicological properties of pharmaceuticals and is catalyzed by drug metabolizing enzymes. Predicting of drug metabolism in humans based on animal experiments is complicated by species differences in the catalytic properties of these enzymes. This review describes and evaluates the use of recombinant models that contain human drug metabolizing enzymes to facilitate the prediction of pharmacokinetical properties of candidate drugs in humans.

Objective To observe the clinical effect of Yangjinhua Powder Capsule(Flos Daturae Powder Capsule)in the treatment of Parkinson's disease(PD).Methods Of the 51 PD patients,15 who came for the first visit were administered Yangjinhua Powder Capsule only,and 36 who had been taking western medicine were given Yangjinhua Powder Capsule without stopping using the original medicine.The Unified Parkinson Disease Rating Scale(UPDRS)was used to score the patients before treatment,7 days,3 months,and 6 months after treatment respectively,and as well to evaluate the total effect and untoward reactions.Results After treatment,29(56.86%)patients were remarkably improved;11(21.57%)patients were improved;and 2(3.92%)patients were slightly improved.Totally 42 patients were improved.The total effective rate was 82.35%.After 7 days' treatment,the improvement of tremor was significant(P

Objective To investigate the value of low-dose MDCT in the diagnosis of breast cancer using ROC analysis. Methods Retrospectively analyze the breast images of 105 cases that had performed both 64-row CT and pathological examinations. The case number that underwent CT examination with routinedose parameters was 48; and that with low-dose was 57. Two radiologists with clinical experiences more than 5 years evaluated the breast lesions, respectively. And ROC curve was used to test the diagnostic efficacy of breast cancer between the two groups. Results Compared with the routine-dose group, the quality of CT image was high enough to disclose the breast lesions while the exposure dose was significantly decreased. The areas under the ROC curve between the routine-dose group (0.943) and the low-dose group (0.908) did not show significant difference (P >0.05). Conclusion Low-dose thin-slice MDCT with contrast enhancement can efficiently and safely diagnose breast cancer.

Objective To study the chemical constituents of the EtOAc soluble fraction obtained from the stems and branches of Euonymus alatus with anti-myocardial ischemic effect. Methods Chemical constituents were isolated and purified by solvent extraction together with various chromatographic techniques, and the structures were identified by physicochemical properties and spectral analyses. ResultsFive compounds, 1-[3-?-D-glucopyranosyloxy)-4, 5-dihydroxyphenyl]-ethanone (Ⅰ), phenethyl alcohol 8-O-?-D-glucopyranosyl-(1→2)-?-D-glucopyranoside (Ⅱ), eugenyl-O-?-D-glucopyranoside (Ⅲ), hyperin (Ⅳ), and hesperidin (Ⅴ) were isolated. Conclusion Compound Ⅰ is determined as a new compound named guijianyuside. Compounds Ⅱ and Ⅲ are isolated from this plant for the first time.

Objective To identify Isatidis Radix in different areas by SDS-PAGE;To provide the basis for the identification and quality evaluation of Isatidis Radix. Methods By using SDS-PAGE technology, the protein profiles of Isatidis Radix in Heilongjiang and Hebei regions were established. Results Isatidis Radix protein in Heilongjiang contained about 13 protein subunits, and the major subunits were 10.5 kD, 23.0 kD, 24.9 kD, and 44.1 kD. Isatidis Radix protein in Hebei contained about 12 subunits, and the major subunits were 55.6 kD, 45.9 kD, 34.3 kD, 18.9 kD, 12.4 kD, and 10.5 kD. Conclusion SDS-PAGE technology can be used as one of the references to identify Isatidis Radix in different areas.

To generate an epitope-mutated foot-and-mouth disease virus (FMDV) as a marker vaccine, the infectious clone pAsia 1-FMDV containing the complete genomic cDNA of Asia 1 type FMDV was used as backbone, the residues at positions 27 and 31 in the 3D gene were mutated (H27Y and N31R). The resulting plasmid pAsia 1-FMDV-3DM encoding a mutated epitope was transfected into BHK-21 cells and the recombinant virus rAsia 1-3DM was rescued. The recombinant virus showed similar biological characteristics comparable with the parental virus. In serological neutralization test the antisera against recombine virus have a good reactivity with parental virus. The antisera against the mutant virus were shown to be reactive with the mutated epitope but not the wild-type one. The results indicated that the two virus strains could be distinguished by western blotting using synthetic peptides. This epitope-mutated FMDV strain will be evaluated as a potential marker vaccine against FMDV infections.
Animals ; Cell Line ; DNA, Complementary ; Epitopes ; genetics ; Foot-and-Mouth Disease Virus ; genetics ; Immune Sera ; Neutralization Tests ; Transfection