Objective To explore the clinical effect of minimally invasive puncture combined urokinase treatment of hypertensive intracerebral hemorage.Methods As a retrospective study,90 patients with hypertensive intracerebral hemorage were treated,they were divided into the observation group and control group,each group had 45 cases.The control group was given traditional surgical operation treatment,the observation group was given YL -1 type of disposable needle with urokinase treatment.The data of operation time,hematoma clearance time,ratio of rehaemorrhagia,hospitalization time and clinical effect in the two groups were analyzed by the software of SPSS 21.0.Results The operation time(χ2 =17.507,P =0.000),hematoma clearance time(χ2 =44.272,P =0.000)and hospitalization time(χ2 =10.601,P =0.000)in the observation group were significantly shorter than those of the control group,the difference was statistically significant.The ratios of rehaemorrhagia in the observation group and the control group,were no statistically significant(χ2 =0.385,P =0.535).The excellent and good ratio was 60.0% in the observation group,significantly higher than the 28.9% in the control group,the difference was statistically signifi-cant (χ2 =8.820,P =0.003).Conclusion The clinical effect of minimally invasive puncture combined urokinase treatment of hypertensive intracerebral hemorage is better than the traditional surgical operation treatment.

Hospital information management has penetrated into each aspect of hospital management.We discussed briefly the role of the hospital information system in medical records management in Chinese medicine hospital on information sharing,data statistics and convenience of case consulting and management,which improved greatly the efficiency of medical records management.

Oxygen sensitive potassium channels can sense the change of oxygen pressure and mediate modifications in cell excitability,contractivity and secretory activity. Several oxygen sensitive K + channels subunits have been identified: Kv 1 2, Kv 1 4, Kv 1 5, Kv 2 1, Kv 3 1 b, Kv 3 3, Kv 3 4, Kv 4 2, Kv 4 3, Kv 9 3, K ATP , K Ca , TASK 1 and hTASK3. There are three mechanisms about the oxygen sensitivity of potassium channels. The subtypes and mechanisms of oxygen sensitive potassium channels variy from different cells and species. Discovery of the subunits of the oxygen sensitive potassium channels and their mechanisms might help to develop understanding and treatment of ischemic disorders, such as stroke, myocardial infarction, pulmonary hypertention as well as reperfusion injury.

Objective:To observe the factors of adverse drug reactions in the nervous system.Methods:197 cases of adverse drug events in the nervous system were collected and analyzed in our hospital from January,2007 to December, 2008.Results:In the 197 cases,80 patients(about 40.61%) were above 60 years old,and 149 patients(about 75.63%) were medicated by i.v.183 cases belonged to the scope of ADRs,and the other 14 cases,to ADEs.The main drugs were anti -bacterials which caused ADR/ADE of the nervous system,and the second were traditional Chinese drug preparations. Conclusion:The ADRs in the neurological system were involved in many kinds of drugs,and had many clinical manifestations. The clinicians should pay attention to them.

PKC plays a pivotal role in the mechanism of myocardial preconditioning. After preconditioning, PKC is activated and translocated to membranes and cytoskeleton structures by multiple endogenous substances such as adenosine, calcium, etc. Recent studies imply that MAPK carries the signal from PKC to the mitochondria K ATP channel and thus protect the heart.

Objective To study the application effects of from-bottom-to-up objective management model in nursing quality control.Methods Eight surgical departments in our hospitals were selected as research objects.Traditional objective management model was applied in the control group (8 004 cases,9 453 visiting times) from June 2012 to June 2013.From-bottom-to-up objective management model was applied in the experimental group (8169 cases,9 603 visiting times) from July 2013 to July 2014.Nursing work quality and continuous improvement projects were compared between two groups by questionnaire survey,a return visit by telephone and statistical evaluation.Results The satisfaction of patients with nurses' service attitudes and professional technology level and the awareness of patients about major nurses in the experimental group were significantly higher than those in the control group [95.56％ (7 806/8 169),95.19％ (7 776/8 169),97.17％ (7 938/8 169) vs.93.22％ (7 461/8 004),92.62％ (7 413/8 004),84.60％ (6 771/8 004),allP＜0.01].Patient complaints and the incidence of nursing adverse events in the experimental group were significantly lower than those in the control group (46,16 cases vs.85,39 cases,x2=9.783,P＜0.01).Conclusions Applying from-bottom-to-up objective management model could cultivate self-control abilities and innovation awareness of nurses,which can improve nursing work quality.

OBJECTIVE:To understand the teaching effect of cooperative training model between colleges and hospitals,and provide reference for the teaching effect of clinical pharmacy. METHODS:Questionnaire survey was conducted on 87 clinical phar-macy students that joint trained by our hospital and Chongqing Medical University. The questionnaire included the students’opin-ions on teachers,teaching materials,teaching methods and suggestions for teaching improvement,all the questionnaires were col-lected and analyzed. RESULTS:There were totally 87 effective question naires with effective rate of 100%. 94.25% of students showed overall satisfaction in cooperative training model between colleges and hospitals,however,5 students thought distribution of the theoretical study time and the traine time still exist some problems;57.48% of students considered the textbook was not suit-able to use and they made recommendations;25.29% of students thought that clinicians responsible for teaching was not appropri-ate,the main reason was clinicians were not clear enough for drug teaching. CONCLUSIONS:Compared with traditional teaching model,the clinical pharmacist training model of cooperation between college and hospital has certain advantages,but some prob-lems still exist in the teachers,textbooks and curriculum arrangements,which need to be further improved.

Objective To detect the correlation between the periodontal bone loss and carotid calcifications by using MSCT.Methods Imaging materials of 270 patients who were suspected atherosclerosis and underwent MSCT were retrospectively studied.According to the score of carotid calcification,the patients were divided into three groups:slight calcification group (carotid calcification score <100),severe calcification group (carotid calcification score ≥100),and normal control group (carotid calcification score=0).The original images were post-processed with volume rendering(VR),multi planar reformation(MPR),curved planar reformation(CPR)and maximum intensity projection (MIP)by using EBW4.5 workstation,and then the residual teeth number and the periodontal bone loss teeth were recorded in different groups.Results On MSCT,the carotid calcification score and the number of periodontal bone loss were displayed clearly.The number of the periodontal bone loss teeth in the calcification groups were significantly higher than those in the normal control group(P<0.01).Furthermore,the number of the periodontal bone loss teeth was positively correlated with the severity of carotid calcification.Conclusion The periodontal bone loss is highly correlated with the severity of the carotid calcification.The volume reconstruction technique of MSCT is a non-invasive diagnostic testing to detect the periodontal desease and to quantify carotid calcifications.

There are many ways to prepare middle cerebral artery occlusion (MCAO) rat model. The focal cerebral ischemia model es-tablished by the suture-occluded method is widely accepted as an ideal focal cerebral ischemia model, which can be used in the basic and clinical study of cerebral vascular diseases. However, it still has the defects of high technical requirement, large model difference and high animal mortality. A variety of focal cerebral ischemia models were established by changing the retention time of the thread, the road the thread plugging into, the type of thread bolt and the depth of the thread plugging. This article compared different suture-occluded method, as well as the suture-occluded method to other modeling methods, different cerebral ischemia models may be different in the pathophysiology of cerebral infarction, and the effects may also be different.

OBJECTIVE:To provide reference for further developing the use of national essential medicine system and formulat-ing the plan for essential medicine that is consistent with the local situation. METHODS:A questionnaire survey was conducted on site to collect the 1 800 medical staffs chosen from 35 community health service institutions in Xinjiang with multi-stage stratified random cluster sampling to investigate the cognition to the national essential medicine,and it was statistically analyzed by SPSS 13.0 software. RESULTS:Totally 1 800 questionnaires were sent out and 1 642 were effective received with effective recovery of 91.2%. 26.5% acquired such specialized knowledge through professional training,and 50.0% by books and Internet;62.4% did never participated in training. Only 20.2% shared it for patients. The average score of recognition for the system was(6.09±2.86) scores,which was related to age,education,profession,work experience and the title (P<0.01). 75.2% supported this system. CONCLUSIONS:The basic medical staff just have some know of the concept of national essential medicine,but the understanding is still low. It is suggested to improve the cognition level by seminars and continuing training to strengthen reliability of all ethnic groups on essential medicine,change their bad medication habits,popularize common sense of rational drug use and form a good atmosphere for the implementation of the national essential medicine system in the whole society.