Objective To compare the effect between mifepristone and medroxyprogesterone in the treatment of patients with perimenopausal dysfunctional uterine bleeding.Methods 90 patients with perimenopausal dysfunctional uterine bleeding were randomly divided into two groups after diagnostic curettage surgery,the control group (n =45 cases) and the observation group(n =45 cases).The patients in the control group were treated with medroxyprogesterone,while the patients in the treatment group were treated with mifepristone.The endometrial thickness,anemia and menstrual flow were analyzed after three months.Results The total efficient rates were 71.1％ in the control group and 88.9％ in the observation group.There was a significant difference between two groups (P ＜ 0.01).The endometrial thickness,anemia and menstrual flow were improved after treatment in both groups,which were more significantly improved in the treatment group (P ＜ 0.05).Conclusion The mifepristone is significantly better than medroxyprogesterone acetate tablets in the control perimenopausal dysfunctional uterine bleeding.

OBJECTIVE:To study the characteristics of the occurrence of ADR in our hospital so as to promote rational drug use in the clinic.METHODS:Information concerning clinical manifestation,patients'age,dosage forms,route of administration and the related drug variety of 162 cases of ADR reports collected in2004in our hospital were analyzed statistically.RESULTS:The main characteristics of the 162 ADR cases were like the following:the dosage forms of drugs administered was centralized,the patients turned out to be the older one,dosage of drugs were too much,course of treatment was longer,the percentage of allergic response was higher and etc.CONCLUSION:Medical worker should work cooperatively in the monitoring of ADR and promote rational drug use in the clinic.

Objective Study the effect of chlorogenie acids(CHA)on insulin resistance in obese rats induced by high‐fat diet . Methods We induced the obese rat model by feeding high‐fat diet ,obese rat model were divided into 4 groups:model group ,piogli‐tazone group(4 .5 mg/kg) ,CHA large dose group and group ,and finally determinated the levels of glucose tolerance ,serum insulin , serum lipid profiles and others .Results CHA showed a higher anti‐obesity activity with lower rate of increase of obese rats′body weights ,reversingglucose intolerance induced by high‐fat diet ,ameliorating the hyperinsulinemia ,decreaseing the levels of TG and TC ,and increase liver glycogen and muscle glycogen level compared with other group which treated with high‐fat diet .And in‐creased HOMA‐ISI ,decreased HOMA‐IR .Conclusion CHA can ameliorate the symptoms of insulin resistance in obese rats ,which mechanism may be related with CHA can stimulate glucose uptake and utilization by peripheral tissues ,and decrease the the serum levels of FFA ,decrease oxygen stress ,prevent and cure the injury induced by lipid peroxidation .

Resveratrol is a natural phytoalexins.In vivo aud vitro experiments show that resveratrol could inhibit tumor metastasis by multiple approaches,such as influencing the expression level of matrix metalloproteinases and inhibitors,inhibiting tumor angiogenesis and interferencing signaling pathways,et al.

Objective To study the correlation of multiple factors with phlegm blood-stasis syndrome(PBSS) of coronary heart disease(CHD),and to explore the objective evidence for the clinical research.Methods A total of 135 cases was enrolled,which were divided into PBSS group(N=87) and non-PBSS group(N=48).Meanwhile,28 healthy volunteers served as the normal control.Five aspects including symptom scoring,hazard factor,basic laboratory examination,inflammatory factors and the result of coronarography were compared in the three groups.Results PBSS was the dominated syndrome of CHD.Symptom score in PBSS was higher.The analysis results of hazard factors of CHD showed that the body weight index,hypertension and the abnormal level of blood lipid were closely related with PBSS of CHD.The incidence of PBSS of CHD had a close relationship with the increased levels of total cholesterol(TC) and low-density lipoprotein cholesterol(LDL-C) in blood lipid examination.Of the inflammatory factors,C-reactive protein(CRP),tumor necrosis factor ?(TNF-?),interleukin 6(IL-6),soluble CD40 ligand(SCD40L) and intercellular adhesion molecule 1(ICAM-1) levels were closely related with PBSS of CHD.The pathological changes of coronary artery of PBSS involved multiple vessels,and were severe.Conclusion Phlegm blood-stasis syndrome of coronary heart disease is relevant with multiple factors.

Objective To analyze the characteristics of epidemic situation of HIV/AIDS in Yongzhou from 1993 to 2014,and provide evidence for HIV/AIDS prevention and control strategy.Methods Descriptive epidemiological analysis was conducted on HIV/AIDS epidemic situation in Yongzhou from 1993 to 2014.Results A total of 2 917 HIV/AIDS cases were reported,the reported cases increased year by year;the ratio of male to female cases was 2.30∶1 ;52.04% were aged 20-49 years old,46.76% were aged ≥50 years old,the percentage of population ≥50 years old increased obviously in recent years;the major transmission route was sexual contact (88.48% ),gay transmission accounted for 2.64%.Conclusion The knowledge about AIDS in Yongzhou should be strengthened, intervention in high risk population should be implemented,scope of detection should be expanded,so as to prevent the transmission of AIDS effectively.

Aconite roots are a common clinical poisonous herb in Chinese herb. It has the effect of restoring yang and rescuing collapse, supplementing fire and assisting yang, eliminating cold and relieving pain. It is used in the treatment of yang collapse and yang deficiency syndromes. It is called principle medicine of all medicines. Monks-hood polysaccharide is one of effective components in Aconite roots. The study found that monkshood polysaccharide has effects of immune regulation, antitumor, myocardial preservation, lipid lowering, etc.

Objective To investigate the effects of Astragalus polysaccharide (APS) on damage of keratinocytes in ultraviolet B (UVB) radiation skin in HaCaT cells; To preliminarily explore its mechanism of action.Methods HaCaT cells were treated by UVB irradiated for modeling. Blank control group, model group, UVB irradiation group and low-, medium- and high-dose APS interventional groups were set up. Each medication group was given relevant medicine. MTT assay was used to determine the cell activity; GSH-Px, CAT, SOD activity and MDA content were detected by biochemical colorimetric method; contents of TNF-α and IL-6 were detected by ELISA.Results Compared with the control group, the contents of SOD, CAT and GSH-Px in the model group decreased significantly, while the contents of MDA, TNF-α and IL-6 increased significantly (P<0.05); compared with the mode group, the contents of SOD, CAT and GSH-Px in the medication groups increased significantly, while the contents of MDA, TNF-α and IL-6 were reduced significantly (P<0.01).Conclusion APS can reduce the oxidative stress injury of UVB to HaCaT cells to some extent.

Objective To study expression of matrix metalloproteinase‐9(MMP‐9) protein and its mRNA in breast cancer and e‐valuate its significance in the occurrence ,development and metastasis of breast cancer .Methods The protein expression of MMP‐9 breast cancer were detected by using immunohistochemistry and the expression of mRNA were detected by reverse transcription polymerase chain reaction(RT‐PCR)Results The positive rate of MMP‐9 protein expression in 56 cases of breast cancer was 69 .6% (39/56) ,while in benign breast diseases was 20% (6/30) ,which were significantly different(P<0 .05) .The levels of MMP‐9 mRNA were significantly higher in the patients with breast cancer than those in benign breast diseases(P<0 .05) ,which were 0 .914 2 ± 0 .108 1 and 0 .379 4 ± 0 .0428 respectively .Conclusion The MMP‐9 protein and mRNA expression in human breast cancers are positively correlated with the stage and lymph node metastasis .Expression of MMP‐9 could be used as an indicator for the ability of invasion and metastasis of breast cancer .

OBJECTIVE:To compare clinical efficacy,safety and economy of urokinase and alteplase each combined with Enoxaparin sodium in the treatment of acute ST segment elevation myocardial infarction (STEMI). METHODS:80 STEMI pa-tients were randomly divided into control group and observation group,with 40 cases in each group. Both groups received Aspirin enteric-coated tablet for antiplatelet aggregation,and Clopidogrel hydrogen sulfate tablet for anticoagulation before thrombolysis. Control group were given urokinase 1 500 000 U added into 0.9% Sodium chloride injection 100 ml,ivgtt,within 30 min;given Enoxaparin sodium injection 7 500 U intramuscularly 12 h after thrombolysis,for 3-5 d. Observation group was given Enoxaparin sodium 60 U/kg,ivgtt,1 mg/ml Alteplase for injection 8 ml with intravenous push,other 42 ml ivgtt within 90 min;continued to receive Enoxaparin sodium with 12 U/(kg·h)micro-pump for 48 h,followed by Low molecular weight heparin calcium injection 5 000 U intramuscularly,bid,for consecutive 5 d. Clinical efficacy of 2 groups were observed,and thrombolytic recanalization situa-tion were observed 30,60,90 and 120 min after thrombolysis. ECG,cost-effectiveness and ADR were also observed. RESULTS:The effective rate of observation group(92.50%)was significantly higher than that of control group(85.00%). The rates of throm-bolytic recanalization in observation group 60,90 and 120 min after thrombolysis were significantly higher than in control group, with statistical significance(P<0.05). Q wave time,Qwave/Rwave and ST segment deviation of observation group after treatment were significantly lower than those of control group,with statistical significance(P<0.05). The total hospitalization cost of obser-vation group was significantly higher than that of control group,with statistical significance(P<0.05);there was no statistical sig-nificance in effective rate and the per unit cost of thrombolytic recanalization rate (P>0.05). The incidence of ventricular aneu-rysm,pericardial effusion,heart failure or cardiac shock,angina pectoris after infarction,severe arrhythmia,death and other as-pects in observation group were significantly lower than in control group,with statistical significance(P<0.05). CONCLUSIONS:Alteplase and enoxaparin thrombolysis therapy is better than urokinase and enoxaparin for STMEI in respects of clinical efficacy, and thrombolytic recanalization with less ADR and better safety;urokinase is cheaper and better than alteplase in cost-effectiveness ratio. Both of them can be used after careful consideration.