OBJECTIVE:To study the characteristics of the occurrence of ADR in our hospital so as to promote rational drug use in the clinic.METHODS:Information concerning clinical manifestation,patients'age,dosage forms,route of administration and the related drug variety of 162 cases of ADR reports collected in2004in our hospital were analyzed statistically.RESULTS:The main characteristics of the 162 ADR cases were like the following:the dosage forms of drugs administered was centralized,the patients turned out to be the older one,dosage of drugs were too much,course of treatment was longer,the percentage of allergic response was higher and etc.CONCLUSION:Medical worker should work cooperatively in the monitoring of ADR and promote rational drug use in the clinic.

Objective To compare the effect between mifepristone and medroxyprogesterone in the treatment of patients with perimenopausal dysfunctional uterine bleeding.Methods 90 patients with perimenopausal dysfunctional uterine bleeding were randomly divided into two groups after diagnostic curettage surgery,the control group (n =45 cases) and the observation group(n =45 cases).The patients in the control group were treated with medroxyprogesterone,while the patients in the treatment group were treated with mifepristone.The endometrial thickness,anemia and menstrual flow were analyzed after three months.Results The total efficient rates were 71.1％ in the control group and 88.9％ in the observation group.There was a significant difference between two groups (P ＜ 0.01).The endometrial thickness,anemia and menstrual flow were improved after treatment in both groups,which were more significantly improved in the treatment group (P ＜ 0.05).Conclusion The mifepristone is significantly better than medroxyprogesterone acetate tablets in the control perimenopausal dysfunctional uterine bleeding.

Objective Study the effect of chlorogenie acids(CHA)on insulin resistance in obese rats induced by high‐fat diet . Methods We induced the obese rat model by feeding high‐fat diet ,obese rat model were divided into 4 groups:model group ,piogli‐tazone group(4 .5 mg/kg) ,CHA large dose group and group ,and finally determinated the levels of glucose tolerance ,serum insulin , serum lipid profiles and others .Results CHA showed a higher anti‐obesity activity with lower rate of increase of obese rats′body weights ,reversingglucose intolerance induced by high‐fat diet ,ameliorating the hyperinsulinemia ,decreaseing the levels of TG and TC ,and increase liver glycogen and muscle glycogen level compared with other group which treated with high‐fat diet .And in‐creased HOMA‐ISI ,decreased HOMA‐IR .Conclusion CHA can ameliorate the symptoms of insulin resistance in obese rats ,which mechanism may be related with CHA can stimulate glucose uptake and utilization by peripheral tissues ,and decrease the the serum levels of FFA ,decrease oxygen stress ,prevent and cure the injury induced by lipid peroxidation .

Objective To study the correlation of multiple factors with phlegm blood-stasis syndrome(PBSS) of coronary heart disease(CHD),and to explore the objective evidence for the clinical research.Methods A total of 135 cases was enrolled,which were divided into PBSS group(N=87) and non-PBSS group(N=48).Meanwhile,28 healthy volunteers served as the normal control.Five aspects including symptom scoring,hazard factor,basic laboratory examination,inflammatory factors and the result of coronarography were compared in the three groups.Results PBSS was the dominated syndrome of CHD.Symptom score in PBSS was higher.The analysis results of hazard factors of CHD showed that the body weight index,hypertension and the abnormal level of blood lipid were closely related with PBSS of CHD.The incidence of PBSS of CHD had a close relationship with the increased levels of total cholesterol(TC) and low-density lipoprotein cholesterol(LDL-C) in blood lipid examination.Of the inflammatory factors,C-reactive protein(CRP),tumor necrosis factor ?(TNF-?),interleukin 6(IL-6),soluble CD40 ligand(SCD40L) and intercellular adhesion molecule 1(ICAM-1) levels were closely related with PBSS of CHD.The pathological changes of coronary artery of PBSS involved multiple vessels,and were severe.Conclusion Phlegm blood-stasis syndrome of coronary heart disease is relevant with multiple factors.

Resveratrol is a natural phytoalexins.In vivo aud vitro experiments show that resveratrol could inhibit tumor metastasis by multiple approaches,such as influencing the expression level of matrix metalloproteinases and inhibitors,inhibiting tumor angiogenesis and interferencing signaling pathways,et al.

Objective:To observe the influence of Xinfeng capsule(XFC) on pulmonary HRCT images and cytokines(TNF-?,IL-10) in blood serum adjuvant arthritis rats.Methods:60 rats were averagely divided into normal control group,model control group,methotrexate(MTX) treated group,tripterygium wilfordii polycoride tablet(TPT) treated group, XFC treated group,12 in each.Except for the rats of normal group,the others were intracutaneously injected with 0.1 ml of Freund’s complete adjuvant in the right hindlimb.After 19 days,different drugs were given to all rats. Pulmonary HRCT images were obtained and the blood samples were reserved for assaying cytokines.Results:In model control group ,the lungs’ outlines weren’t clear and the blood vessels expanded with the edges of them being obscure and unregular. There were high density images shaped as rope and slip in lungs of model control group rats and the pleura near the images were a little thickening. In MTX treated group, there were high density images shaped as slice along pulmonary veins. The veins of the blood vessels were obscure and the edges were unclear. In TPT treated group,there were multiple high density images shaped as tubercle and slice and the boundary were not clear. In XFC treated group, the lungs’ outlines were clear and the veins were well-distributed. High density images shaped as spot were found in part lungs. Compared with normal control group,tumor necrosis factor-?(TNF-?) in blood serum ascended obviously in model control group(P0.05).Conclusion:XFC eliminates swelling by down-regulating the levels of TNF-?, up-regulating the levels of IL-10, restraining the inflammatory reaction.In adittion,cytokines participated in forming pulmanory fibrofication.So the changes of pulmanory HRCT images were also improved at the same time.

0.05).Conclusions:There was no difference in terms of both effect and toxicity among the three regimens. All of them were effective and could be well tolerated by advanced colorectal cancer patients.

OBJECTIVE:To investigate the protective effects of NIF,NHH,TNHH on focal cerebral ischemic injury induced by middle cerebral artery occlusion in rats.METHODS:24 SD rats were randomly divided into 4 groups:control group(n=6)received normal saline 0.1ml/kg,group NIF(n=6),group NHH(n=6)and group TNHH(n=6)received NIF,NHH,TNHH 2mg/kg i.v.(NIF,NHH,TNHH were dissolved in normal saline 2mg/kg)respectively just before middle cerebral artery occlusion(MCAO)with 3～0 nylon monofilament suture for 3 days.The neurological behavior was evaluated at 4hr,8hr,24h,48h,72h after operation.The infarct volume was then assessed after TTC staining following the last neurological behavior evaluation.Two specimens were randomly taken in 4 groups and were sent to HE staining.RESULTS:The neurologic defect score(NDS)of group NIF,NHH,TNHH after operation decreased significantly(P

Objective:To establish a headspace capillary GC method for the determination of residual solvents in bromfenac sodi-um. Methods:A headspace GC was used to separate the residual solvents on an HP-5 capillary column with an FID detector. The car-rier gas was nitrogen at the flow rate of 0. 8 ml·min-1 . The temperature of the injector was 200 ℃ and that of the FID was 250 ℃. The programmed column temperature was set as follows:maintained at 40℃ for 10 min, and then raised to 150℃ at the rate of 30℃·min-1 and maintained for 5 min. The containers of headspace injector were in equilibrium at 100 ℃ for 20 min. Dimethyl sulfoxide was used as the solvent. The amount of the residual solvents, such as methylbenzene, isopropanol, dichloromethane, methanol and iso-propyl ether was calculated by an external standard method. Results:All the solvents could be completely separated with good linear relationship. The average recovery of the five solvents was 98. 9%( RSD =2. 01%),99. 2% ( RSD =1. 95%),99. 6% ( RSD =1. 65%),100. 5%(RSD=1. 38%)and 100. 8%(RSD=1. 36%)(n=9),respectively. Conclusion:The method is simple and accu-rate in the determination of the five residual solvents in bromfenac sodium.

Objective To observe effects of Xinfeng capsule(XFC)on depressive mood and serum cortisol in patients with rheumatoid arthritis and study its mechanism.Methods 76 RA patients were randomly divided into two groups.The treatment group(n=40)was treated with XFC,and the control group(n=36)with Zhengqing Fengtongning.The targets included clinical effects,symptom and sign,integral of quality of life,self-rating depression scale(SDS)and serum cortisol.Results The effects of XFC were similar to that of Zhengqing Fengtongning in the total effective rate,improving symptoms and sign,active index,etc.XFC was superior to Zhengqing Fengtongning in improving SDS standard score,the symptoms of splenic asthenia and quality of life(P