After a description of the concept and features of SoLoMo, and its effect on the transformation of academic libraries, it was pointed out that academic libraries should provide characteristic service and realize seamless interac-tion between library and learners by making full use of the advantages of social network tools, local and mobile service .

Metabolic bone disease in nephrotic syndrome(NS) are increasingly being renal physician's attention.As calcium binding protein and VitD binding protein losing with a large number of protenuria, the bone metabolic biochemical abnormalities had happened at the beginning of the onset of the nephrotic syndrome, and is further exacerbated by therapeutic high-dose or long course of glucocorticoids (GC) application.The main mechanism of the glucocorticoid-induced osteoporosis (GIOP) is for GC to inhibit the activity of osteoblasts and promote apoptosis of osteoblasts and formation of osteoclasts, resulting in secondary hyperparathyroidism,leading to increasing the risk of osteoporosis,slow growth and fracture,seriously harm to children's physical and mental health.The biomarkers of bone transform can prompt the NS with bone metabolic abnormalities early;vertebral body bone dual-energy X-ray absorptiometry bone mineral density detection is the best method and position to determine GIOP.As the most commonly used and effective means to prevent and control metabolic bone disease, calcium supplements and VitD were always taken when GC was treated for NS, even the dosage of GC was very low.So far, it is still lack of guideline of prevention and treatment of bone metabolic abnormalities in NS in children.

Objective To observe the effect of oxymatrine on the Absorption of carbohydrate and fat and the activity of peroxisome proliferator activated receptor ? and ?.Methods 64 masculine SD rats were randomly divided into three groups,20 sugar tolerance test,20 triacylglycero Absorption test and 24 oxymatrine effecting on triacylglycero and cholesterin test,and observed the effect of oxymatrine on glycosidase activity,blood sugar and activity of peroxisome proliferator activated receptor ? and ?.Results ① The depressant effect of oxymatrine on the activity of glycosidase was strengthened by the increased dosage.② Oxymatrine could suppress the upgraded level of blood sugar after took amylon and cane-sugar,and inhibit the upgraded level of triacylglycerol after feed by olive oil and hypso-cholesterol,but did not suppress the upgraded level of blood sugar after took glucose and hardly influence the level of high density lipoprotein cholesterol and low density lipoprotein cholesterol.③ Oxymatrine could obviously activate the activity of peroxisome proliferator activated receptor ? and ?,the activity of peroxisome proliferator activated receptor ? and ? increased gradually by the augment of the oxymatrine,and expressed evident dose-response relation.Conclusions Oxymatrine could not only directly inhibit the Absorption of triacylglycerol and depress the elevated level of postprandial triacylglycerol,but also activate peroxisome proliferator activated receptor ?,moreover possess dose-response relation.

A collective intelligent perception-supported and RDAWA-based reader-driven acquisition model of li-brary holdings was proposed with the development of academic library holdings as its background .The design ideas of RDAWA were described , the master framework of RDAWA was analyzed , the considerations in design of RDAWA that simplified the input procedure and met the reading requirements of readers were elaborated with the biblio-graphic information database , data analysis module and acquisition order generation algorithm summarized .

Objective To evaluate the effect of probucol combined with simvastatin on blood levels of oxidied low density lipoprotein (ox-LDL) and inflammatory factors in acute stage of cerebral infarction. Methods A total of 122 patients with acute stage of cerebral infarction were randomly divided into two groups:observation group ( n = 62),and control group( n = 60). After two weeks of follow-up ,the levels of high sensitivity C-reactive protein(hsCRP) ,oxLDL ,fibrinogen ( FIB ), interleukin 6 (IL-6) and blood lipids were detected. The side effect was recorded and the difference between two groups was analyzed. At 7 d and 14 d, curative effects were evaluated by standard scale of clinical neurological deficit. Results Compared with the control group, 2weeks after the medication, low-density lipoprotein cholesterol( LDL-C), apolipoprotein B ,ox-LDL, IL-6 and hsCRP were significantly decreased in the observation group (P <0.01 ). Conclusion The treafment of probucol combined with simvastatin could reduce the levels of ox-LDL and inflammatory factors in acute stage of cerebral infarction, and prevent hemorrhagic transformation and recurrence of cerebral in farction.

Objective To investigate the pollution status of algae and microcystin(MC)in Dianshan Lake,Shanghai City and Poyang Lake,Jiangxi Province.Methods Water samples were collected from different sites of the above lakes,as the pretreatment of intracellular and extracellular microcystins was finished,MC-LR concentration was detected by ELISA.Results The proportion of Cyanobacteria in Dianshan Lake was 38.8% and 68.2% respectively,the mean content of MC was 281.78 and 1 145.77 pg/ml respectively.In Poyang Lake,the proportion of Cyanobacteria was 48.9% and 73.7% respectively,the mean content of MC was 80.53 and 405.65 pg/ml respectively.In the same water-blooming lake,MC content was significantly lower in July than that in October(P

The substantia gelatinosa of subnucleus caudalis of the trigeminal nerve of the rat shows an intense extralysosomal acid phosphatase activity which disappears after the removal of it's skin of the facial regions.Different regions of the facial skin of 69 rats were excised and the projections of the cutaneous nerves were traced by studying the extralysosomal acid phosphatase activity with the modified Gomori's methods.A somatotopical localization was found within the substantia gelationosa. It agreed with what has been found in earlier studies where other techniques have been used. The findings showed that the fibers of the cutaneous areas along the dorsoventral axis of the body were found in a reverse order in the receptive fields in the substantia gelatinosa. The vertex and fore-head lay in the ventral, while skin of the mandibular areas in the dorsal region, and the skin of the facial areas lay successively from ventral to dorsal in following order: vertex and forehead eye region, dorsal vibrissae, ventral vibrissae-upper lip and finally lower lip-mandibulare region, in the receptive fields of the substantia gelatinosa.The cutaneous facial regions were disproportionately represented in substantia gelatinosa, for example, the field receiving projections from the vibrissae areas or fields were as large as 4mm~2 in the most medial portion of the ventral vibrissae-upperlip which are disproportionately large while the fields receiving projections from the forehead and mandibular cutaneous regions were disproportionately small. The provides a possible explanation for the specific function of analgesia of the acupuncture point Renzhong.

Objective:To observe the effects of remifentanil on hemodynamics and plasma angiotentratin-Ⅱ (AgⅡ) level in children with cleft palate undergoing repair operation.Methods:Fifty patients,ASA Ⅰ-Ⅱ, were randomly divided into two groups,remifentanil group (R group) and fentanyl reoup (F group).Patients in R group received remifentanil combined with propofol anesthesia,those in F group received fentanyl combined with propofol anesthesia.Vecuronium bromide was given as muscle relaxant in both groups.ECG,HR,BP and SpO_2 were monitored in all the patients during operation,and peripheral venous blood samples were taken 1 d before operation(T1 ),at the time of endotracheal intubation(T2),10 min after operation beginning(T3),5 minutes after extubation(T4) for the check of plasma AgⅡ level.Results:At T2 and T3 HR,SBP,DBP and plasma AgⅡ level were significant lower in both group of the patients (P

Objective To study the influences of endogenous testosterone on vascular endothelial cell function and structure in rabbits of balloon injury. Methods Twenty male rabbits were randomly divided into two groups: castrated group and control group.The former group animals were castrated and the later group animals received sham operation. All animals were performed with deendothelializing balloon injury in the right iliac artery. Nitric oxide (NO) and endothelin-1 (ET-1) were measured at different intervals during the experiment. After 2 weaks of endothelial denudation all animals were killed, and endothelin structure and morphological changes were observed with electron microscope and HE staining. Results There weren′t siginificant differences of plasma NO and ET-1 levels between the two groups, but plasma NO and ET-1 levels of the castrated group 2 weaks after endothelial denudation recovered to the levels before castration, while they didn′t in the control group. The extent of reendothelialization and intimal area of the harvested segments were similar between the two groups. Conclusion The decrease of endogenous testosterone level did not affect endothelial cell structure, but tended to protect function of injured endothelium.

Objective To investigate the effect of vitamin D combined with iron succinate on children with premature anemia .Methods 66 patients with premature anemia from November 2013 to June 2015 in our hospital were selected and randomly divided into the control group and the experiment group, with 33 cases in each group.The patients in the both groups were give regular treatment, the experimental group was given the protein succinate oral solution (phenipril) 1.5 mL/kg on the basis of conventional treatment, Vitamin D drops ,one times a day.Two groups were treated continuously for 60 days.The hemoglobin, serum iron, ferritin, liver and kidney function and adverse reactions were compared before and after treatment.Results The hemoglobin, serum iron and ferritin levels in two groups were higher after treatment(P<0.05),compared with the control group,the hemoglobin, serum iron and ferritin levels in the experimental group were higher(P<0.05).Compared with before treatment ,the levels of serum ALT, AST, Cr and BUN in the two groups were not statistically significant.There was no significant difference in adverse reactions between two groups.Conclusion Vitamin D and iron proteinsuccinylate combined treatment of anemia in premature infants clinical curative effect, improve the body hemoglobin, serum iron and ferritin levels, without causing damage to liver and kidney function, drug safety.