1.Serious central nervous system involvement in childhood systemic lupus erythematosus
Haixia GUO ; Wenjun WENG ; Wenyi LI
Chinese Pediatric Emergency Medicine 2001;8(1):22-23
Objective To study the characteristics of serious central nervous system(CNS) involvement in childhood systemic lupus erythematosus.Methods We made a comparison on the level of ANA、dsDNA and positive rate of Sm、C3 between primary and secondary CNS involvement and analysed the clinical manifestations between two groups.Results The level of ANA、dsDNA and ositive rate of Sm、C3 were not related with SLE encephalopathy;EEG was useful to the diagnosis of SLE.Conclusion The differiential diagnosis between primary and secondary CNSD in volvement of SLE must be analysed according to clinical manifestations and other laboratory findings.
2.Clinical observation of efficacy of combinative usage of ipratropium bromide and small dosage of theophylline on patients with COPD
Haixia WENG ; Yuanrong DAI ; Chengyun WU ; Jie LIN ;
Chinese Journal of Clinical Pharmacology and Therapeutics 2000;0(01):-
AIM : To contrastively observe the effects of combinative usage of ipratropium bromide, anti cholinergic inhalant and the small dosage of controlled release theophylline tablets or salbutamol on the patients with COPD. Clinical observation of efficacy of combinative usage of ipratropium bromide and small dosage of theophylline on patients with COPD$$$$ WENG Hai xia, DAI Yuan rong, WU Cheng yun, LIN Jie Department of Respiratory, the Second Affiliated Hospital of Wenzhou Medical College, Wenzhou 325027, Zhejiang, China ABSTRACT AIM : To contrastively observe the effects of combinative usage of ipratropium bromide, anti cholinergic inhalant and the small dosage of controlled release theophylline tablets or salbutamol on the patients with COPD. [WTHZ METHODS : Forty patients with stable COPD were randomly divided into two groups ( n =20 in each): theophylline group or salbutamol group. In theophylline group, each case inhaled 2 puffs of ipratropium bromide ter in die, meanwhile take 0.1 g ophylline capsule orally every 12 hours, measured the maximum and minimum concentration of ophylline. In salbutamol group, each case inhaled 2 puffs of ipratropium bromide and salbutamol ter in die. During 8 weeks trial, the base FEV 1.0 before using medicine and the FEV 1.0 when all the drug were stopped at the end of 1st, 4th, and 8th week was measured, separately. The FEV 1.0 amelioration ratio (△′FEV 1.0 ) compared with base FEV 1.0 was obtained , and another FEV 1.0 amelioration ratio (△FEV 1.0 ) was also detected after bronchodilatation test by salbutamol. Furthermore, PEFR aberration rate was evaluated by measuring peak expiratory flow rate in morning and evening daily. The maximum concentration of ophylline is 8.7 ? 2.1 mg?L -1 , the minimum is 6.1 ? 2.3 mg?L -1 . RESULTS : △FEV 1.0 increased markedly at end of 8th week in theophylline group (P
3.Effect of GLP-1 receptor agonist on lipolysis in adipose tissue of obese mice and its underlying mechanism
Beisi LIN ; Haixia XU ; Hua LIANG ; Kejing ZENG ; Heying AI ; Jianping WENG ; Fen XU
Chinese Journal of Pathophysiology 2015;(11):2021-2026
AIM:To investigate the effects of glucagon-like peptide-1 (GLP-1) receptor agonist exendin-4 on white adipose tissue (WAT) and the underlying mechanisms.METHODS:Male C57BL/6J mice (8 weeks) were chal-lenged by high-fat diet for 12 weeks, and were randomly divided into saline group and exendin-4 group.The mRNA expres-sion of sirtuin 1 (SIRT1), adipose triglyceride lipase (ATGL), TNF-αand adiponectin of WAT was detected by real-time PCR.3T3-L1 adipocytes or mouse embryonic fibroblasts cells were treated with exendin-4 for 24 h.The protein levels of SIRT1, ATGL and hormone-sensitive lipase (HSL) were determined by Western blot.RESULTS:Exendin-4 significantly decreased epididymal fat weight, fasting blood glucose and serum triglyceride levels ( P<0.05) , and reduced body weight and serum TNF-αlevel.The mRNA expression of SIRT1, ATGL and adiponectin in WAT was all significantly up-regulated by exendin-4, which were contrary to the down-regulation of TNF-αmRNA expression (P<0.05).Exendin-4 promoted the protein expression of SIRT1, ATGL, and HSL in 3T3-L1 adipocytes in a dose-dependent manner.Less lipid droplets with up-regulation of lipolytic protein expression were observed when combined with SIRT1 agonist treatment, which were suppressed by SIRT1 inhibitor.Deletion of SIRT1 led to larger adipocytes with more lipid droplets, and the effect of ex-endin-4 on the lipolysis disappeared when SIRT1 was deficient.CONCLUSION:Exendin-4 promotes lipolysis in WAT of obese mice via activation of SIRT1.
4. Effect of tympanic dexamethasone injection in the treatment of different types of sudden deafness
Haixia HE ; Kun YUAN ; Wei CHEN ; Qiong ZHANG ; Yiming HAN ; Jing WENG ; Hong PAN
Journal of Clinical Otorhinolaryngology Head and Neck Surgery 2020;34(2):124-127
Objective:
The aim of this study is to explore the best administration, timing and efficacy of dexamethasone and Mison in the treatment of different types of sudden deafness.
Method:
242 cases of sudden deafness first diagnosed in our department were selected. According to the guidelines(2015), the patients were divided into low frequency descending type (49 cases), high frequency descending type (66 cases), flat descending type (71 cases) and total deafness (56 cases). Different types of patients were randomly divided into tympanic injection group and systemic administration group on the basis of routine treatment. Tympanic injection group was further divided into initial injection group and delayed injection group. Tympanic injection was performed under ear endoscope, once every other day, three times for low frequency descending deafness, and five times for other types of deafness.
Result:
In comparison of total effective rate, there were significant differences among the three treatments in 49 cases of low frequency descending type, 71 cases of flat descending type and 56 cases of total deafness type (P<0.05). In 66 cases of high frequency descending type, there was no significant difference among the three treatments (P>0.05). In the comparison of cure rate, the difference of cure rate among the three treatment methods was also significant in low frequency descending type (P<0.05). In the other three types of deafness, there was no significant difference among the three treatment methods (P>0.05). There was no significant difference in the effective rate between men and women (P>0.05) in all patients treated by tympanic injection. There was significant difference in the effective rate of tympanic injection within 7 days of onset and 7 days after onset (P<0.05).
Conclusion
Intratympanic injection of dexamethasone is safe, effective, and easy to use as an initial treatment for low frequency descent, flat, and full deafness, and the sooner the better.
5.Effect of tympanic dexamethasone injection in the treatment of different types of sudden deafness.
Haixia HE ; Kun YUAN ; Wei CHEN ; Qiong ZHANG ; Yiming HAN ; Jing WENG ; Hong PAN
Journal of Clinical Otorhinolaryngology Head and Neck Surgery 2020;34(2):124-127
The aim of this study is to explore the best administration, timing and efficacy of dexamethasone and Mison in the treatment of different types of sudden deafness. 242 cases of sudden deafness first diagnosed in our department were selected. According to the guidelines(2015), the patients were divided into low frequency descending type (49 cases), high frequency descending type (66 cases), flat descending type (71 cases) and total deafness (56 cases). Different types of patients were randomly divided into tympanic injection group and systemic administration group on the basis of routine treatment. Tympanic injection group was further divided into initial injection group and delayed injection group. Tympanic injection was performed under ear endoscope, once every other day, three times for low frequency descending deafness, and five times for other types of deafness. In comparison of total effective rate, there were significant differences among the three treatments in 49 cases of low frequency descending type, 71 cases of flat descending type and 56 cases of total deafness type (<0.05). In 66 cases of high frequency descending type, there was no significant difference among the three treatments (>0.05). In the comparison of cure rate, the difference of cure rate among the three treatment methods was also significant in low frequency descending type (<0.05). In the other three types of deafness, there was no significant difference among the three treatment methods (>0.05). There was no significant difference in the effective rate between men and women (>0.05) in all patients treated by tympanic injection. There was significant difference in the effective rate of tympanic injection within 7 days of onset and 7 days after onset (<0.05). Intratympanic injection of dexamethasone is safe, effective, and easy to use as an initial treatment for low frequency descent, flat, and full deafness, and the sooner the better.