Objective To explore the gender differences of brain activation between patients with depression in recognition of dynamically sad expression with magnetoencephalography (MEG) technology and the paradigm of expressional experiment,and further to examine its neurological basis. Methods Brain activities were detected using MEG during the recognition of dynamic facial video with 12 female depressed patients, 11 male depressed patients, and their corresponding normal controls matched by age and education. Results Compared with male depression,female depression showed increased activation during different time periods were in turn as follows: bilateral inferior frontal gyrus ( x, y, z = 58/- 60,12/22,20/20, T = 2.17,1.88 ), left anterior cingulate gyrus ( x, y, z = 64,12,4, T = 2.37 ), bilateral superior frontal gyrus ( x, y, z= 30/-24,64/- 4,0/50, T = 2.86,2.36 ),the left brainstem( x, y,z = - 12, - 16, - 18 ,T = 1.96) ,right middle frontal gyrus( x,y,z =40,60,4,T = 2.22 ),bilateral precentral gyrus(x,y,z = -62/56, 16/10, 10/8. T = 1.99,2.65 ) ,left hippocampus ( x,y,z = - 26,- 14, -20,T = 1.77) ,left parahippocampal gyrus(x,y,z = - 16, - 12, -20,T = 1.72) ,right middle occipital gyrus( x ,y ,z = 50, -76, -14 ,T = 1. 75 ),while the decreased brain activation were in turn in right superior temporal gyrus ( x, y, z = 68, - 18,2, T = 1.85 ), right parahippocampal gyrus ( x, y, z = 20, - 36, - 14, T = 1.92 ), left cuneus( x,y,z = -6, -98,14,T =2.46) ,bilateral temporal middle gyrus( x,y,z =52/-34, - 80/-62,20/28,T = 1.95,2.57 ), left pre-cuneus ( x, y, z = - 40, - 74,38, T = 2.58 ), right hippocampus( x, y, z = 24, - 32, - 18,T = 2.05 ) in recognition of dynamically sad expression. ( p ＜ 0. 05, corrected). Conclusion The data suggest that there may be significant gender differences of functional network in depressed patients during recognizing dynamical sad facial expression.

Objective To explore the features of functional networks about recognizing dynamically positive expression with using magnetoencephalography (MEG) technology and the paradigm of expressional experiment, and further to examine its neurological basis. Methods Twelve depressed patients and twelve age,education-matched healthy controls participated to recognize the dynamically positive expression in the MEG scans. Results In comparison with the healthy,the abnormally activities regions in depressed patients during different time periods were separately as follow;decreased activation in the right inferior parietal lobule(t = 3.94),the right su-pramarginal gyms(t = 3.59),the bilateral posterior cingulated(t = 5. 04, t = 4. 85) ,the bilateral precuneus(t = 3.84) ,the left cuneus(t = 3.58) and increased activation in the bilateral hippocampus(t = 2. 13, t = 2.56) ,the left amygdale(t = 2.41), the bilateral uncus gyrus(t = 2.33, t = 2.44) , the right anterior cingulated (t = 2. 15) , the left fusiform gyms (t = 3. 33) (P < 0. 05, unconnected). Conclusion The results indicate, compared with healthy controls,abnormal brain activities as the weakened function of the medial temporal cortex,parietal lobe and the enhanced function of limbic system were distributed extensively in depressed patients during recognizing dynamically positive expression. These abnormalities may prompt the dynamic characteristics of the magnetic source imaging about recognizing dynamically positive expression,and further reveals the mechanisms of emotional symptoms in depression.

ObjectiveTo study information transmission circumstances within the neural circuits related to the attentional controls of the mate depression patients.MethodsTwelve unipolar depression patients and twelve age- and education- matched healthy controls were involved in the Stroop word-color interference test to detect the variation of brain inhibitory function by Magnetoencephalography scanning.ResultsCompared with the healthy controls,the abnormally activities in depressed patients during in chronological order were separately as follow:decreased activation in the left postcentral gyrus ( t =3.10 ),the right superior frontal gyrus ( t =2.16 ),the left middle frontal gyrus (t=2.64),the left parietal lobe (t=2.89),the right middle temporal grus( t=1.92),the right superior temporal gyrus(t=2.84),the right insula(t=3.03),the right precuneus(t=2.98),the bilateral middle frontal gyros ( t =3.64,t =2.25 ),the right postcentral gyrus ( t =2.20),the right cingulate gyrus ( t =4.04 ),the bilateral precuneus ( t =2.79,t =1.87 ) ;increased activation in the left caudate body ( t =1.91 ),the left pulvinar ( t =2.56),the left middle temporal gyrus( t =1.89),the left precentral gyrus( t =2.02) (P ＜ 0.05,uncorrected).ConclusionThe abnormal activation in the brain regions related with attentional control processing is detected in the male recurrent unipolar recurrent major depression,performances of limbic system increased and.cortex declined more in the recurrent depressed.

ObjectiveTo investigate the variation of executive function of fronto-cingulate cortex in spatio-temporal sequence in recurrent depressed patients.MethodsEighteen recurrent depressed patients and twenty-one age-,gender- and education- matched healthy controls were involved in the Stroop word-color interference test to detect the executive function of anterior cingulate and prefrontal regions by magnetoencephaloraphy scanning.Results 1.Compared to healthy controls,the increased activation of brain regions in depressed patients during different time periods were separately shown as follows( t represents activation strength):( 1 ) 100 ～ 200 ms:the right anterior cingulate gyrus ( t =1.81,T value means activation strength),the bilateral medial frontal gyrus ( t =1.91,t =1.86),the left superior frontal gyms( t =1.79 ),the right middle frontal gyrus( t =1.82 ),the right inferior frontal gyrus ( t =1.82 ).( 2 ) 200 ～ 300 ms:the left anterior cingulate gyrus ( t =1.82 ).( 3 ) 250 ～ 350 ms:the left anterior cingulate gyrus ( t =2.67 ),the left medial frontal gyrus ( t =2.43 ),the left inferior frontal gyrus ( t=1.91 ).(4)300 ～400ms:the left anterior frontal gyrus(t=2.26),the bilateral inferior gyrus( t=1.97,t=2.66),the left medial frontal gyrus(t=2.35).(5)350 ～450ms:the left anterior cingulate gyrus(t=2.02),the left medial frontal gyrus ( t =2.00),the bilateral inferior frontal gyrus ( t =1.74,t =1.78 ).( 6 ) 400 ～ 500 ms:the left anterior cingulate gyrus( t=2.01 ),the left medial frontal gyrus( t =1.97).2.Compared to healthy controls,patients showed decreased activation in the left middle frontal gyms ( t =1.79) and the left superior gyrus(t =1.76) in 200 ～ 300 ms.ConclusionExecutive dysfunction is reflected in depressed patients with the activation inefficiency in anterior cingulate and prefrontal regions in spatio-temporal sequence.

Objective To investigate the food intake of one meal of the hotel customers and evaluate it rationality ,then provide dietary suggestions .Methods Six hundreds hotel customers were investigated in 2 four‐star hotel and 2 five‐star hotel of Nanjing , who were selected with a stratified sampling method .Their 5 days diet were investigated and then the dietary intake ,the percentage of energy from protein ,fat and carbohydrate and the percentage of protein resource were calculated based on the food composition table .Results It was shown that the daily energy intake of one meal was appropriate among the surveyed hotel customers ,and the energy proportion from 3 major nutrients were not reasonable ,and the energy proportion from fat were higher than other 2 major nutrients ;the proportion from the source of good proteins was reasonable ,but the intake of protein was too much;the customers fell short on their daily serving of grains ,eggs ,beans and milk products and the intake of cooking oil and salt was excessive in diets . Their intake of fat ,protein ,retinol equivalent ,niacin ,vitamin E ,sodium and iron were too much .Instead ,they ate less ascorbic acid;only the intake of energy ,riboflavin and thiamine were appropriate .Conclusion The one meal dietary structure of hotel customers is not appropriate ,while nutrition collocation is not reasonable .It is necessary to promote nutrition and health education and some intervention measures must be taken .

Objective To investigate the variation of brain inhibitory function of depressed patients during the processes of the Stroop color-word interference task with the Magnetic source imaging ( MSI) technology. Methods Twenty-three depressed patients and twenty age-,gender- and education- matched healthy controls were involved in the Stroop word-color interference test to detect the variation of brain inhibitory function by magnetoen-cephaloraphy scanning. Results Compared with the healthy controls,the abnormal activities in depressed patients during different time periods were separately as follows: increased activation in the bilateral thalamus( t = 2.46, t = 2.92 ) ,the right temple fusiform gyrus ( t = 1. 81) , the right middle temporal gyrus ( t = 1. 76) , the right inferior frontal gyrus( t = 2.28) , the left anterior cingulate( t = 2.00) , the left caudate head( t=1.81) ,the precentral gy-rus( t = 2.17) ,the right parahippocampal gyrus( t = 2.04) ,the left superior temporal gyrus(t = 2.47) ; decreased activation in the right superior temporal gyrus( t=1.76) ,the bilateral middle frontal gyrus(t=1.95, t = 2.09), the right cuneus( t=1.97) ,the cingulate gyrus( t=1.70, t = 2.08) ,the postcentral gyrus( t = 2.57, t = 2.65) , the left supramarginal gyrus( t = 2. 16) ,the left lentiform nucleus putamen( t = 2.39) ,the bilateral middle temporal gyrus (t = 2.22, t= 1.90) ,the left insula( t= 1. 81) ,the left superior temporal gyrus( t= 1.90) ,the right parietal lobe( t= 3.26). Conclusion The abnormal activation inefficiency in the brain regions related with inhibition function is reflected in depressed patients,and the ability against interference information declines.

Animals ; Eukaryotic Initiation Factors ; genetics ; metabolism ; Humans ; Phosphorylation ; physiology ; Proteomics ; Ribosomal Proteins ; genetics ; metabolism ; TOR Serine-Threonine Kinases ; genetics ; metabolism