Objective To explore the influence of edaravone on serum endothelin(ET),soluble intercellular adhesion moleculel(sICAM-I)and monocyte chemotactic factor 1(MCP-1)and neurological function in acute cerebral infarction patients.Methods 90 patients with acute cerebral infarction were randomly divided into treatment group(additional edaravone)and control group(routine treatment).The serum levels of ET,sICAM-1 and MCP-1were detected by ELESA pretherapy and after treatment.Neurological functional deficit scores(NDS)was utilized for assessment pretherapy and after treatment.Results The levels of serum ET,sICAM-1 and MCP-1 in acute cerebral infarction groups were significantly higher than those of control group(t=4.55,4.62,4.75,4.43,4.61,4.73,all P＜0.05);The levels of serum ET,sICAM-1 and MCP-1,NDS in both two groups after treatment were significantly lower than those before treatment(t=4.12,4.23,4.15,3.91,3.92,3.83,4.52,4.36,all P＜0.05),and the levels of serum ET,sICAM-1,MCP-1 and NDS in the treatment group were significantly lower than those in the control group(t=3.72,3.63,3.53,3.72,all P＜0.05).Conclusion Edaravone can decrease the levels of ET,sICAM-1 and MCP-1in acute cerebral infarction patients.It can lighten acute inflammation and brain injury,protect the tissue of brain.

Objective:approach to the diagnostic value of 18F-FDG PET/CT on primary bronchial-pulmonary carcinoid.Methods:7 cases of peripheral bronchial-pulmonary carcinoid checked with CT and 18F-FDG PET/CT were analyzed retrospectively,the image characteristics,PET/CT standard uptake values were measured and compared with pathology results.Results:carcinoid were found 1 on apex and frontal of the upper right lung each,1 on middle lobe,2 on lower right lung,and 1 on apicoposterior segment of the upper left lung and posterior of lower segment each.The diameter were 3.4￣ 6.2 cm,average 5.4 cm.CT shows the lesions were round or irregular nodus with clear edge and even density similar to soft tissue,2 among which were slightly lobulated,1 with spicular sign and 1 with patching shade around.18F-FDG in all 7 cases were slight or significantly increased,SUV valued 3.3?1.4(2.8￣5.3),2 cases showed uneven distribution with irregular patching and linear defect.FDG uptake in mediastinal and celiac lymph nodes were increased in 1 case.All cases were later proven to be atypical neuroendocrine carcoma carcinoid by surgical pathology and 1 case with mediastinal lymph nodes metastasis Conclusion:bronchial-pulmonary carcinoid can clearly be shown by abnormal FDG concentration on PET image,and its malignancy can be judged base on concentration and structural changes,meanwhile,CT can precisely locate the lesion and provide detailed data of its relationship with surrounding tissue.

BACKGROUND:Bone marrow mesenchymal stem cel s can migrate into tumor tissues, as reported in recent studies.
OBJECTIVE:To investigate the tropism and effect of transplantation of bone marrow mesenchymal stem cel s on proliferation and differentiation of gastric cancer cel line SGC7901 in rats.
METHODS:Gastric cancer models were established in Sprague-Dawley rats by subcutaneous injection of gastric cancer cel line SGC7901, and then, in cel transplantation group, each rat underwent an intraperitoneal injection of 1×107 bone marrow mesenchymal stem cel s. After transplantation, the targeting ability of bone marrow mesenchymal stem cel s was detected using fluorescent DiI labeling. Cyclin D2 mRNA and protein expressions were measured using real-time PCR and western blot assay, respectively. Apoptosis of gastric cancer cel s was observed by in situ terminal labeling method.
RESULTS AND METHODS:Bone marrow mesenchymal stem cel s successful y migrated into the gastric cancer site in rats. The expression levels of cyclin D2 mRNA and protein in the cel transplantation group were significantly higher than those in the model group (P<0.05). It was observed that the number of apoptotic cancer cel s was significantly reduced in the cel transplantation group compared with the model group (P<0.05). These findings indicate that bone marrow mesenchymal stem cel s have the ability to migrate into the tumor sites, thereby promoting the proliferation of gastric cancer cel s.

Objective To investigate the diagnosis and treatment of severe MT patients,and to add a reference for similar cases.Methods From March 2014 to September 2015,the clinical data of 53 patients with severe MT in Liu'an First People's hospital were retrospectively analyzed.Results Four out of 53 cases of severe MT were missed diagnosis (missed diagnosis rate:7.5％);51 cases (96.2％) received surgical treatment;2 cases (3.8％) were treated by non operation,45 cases (84.9％) were treated successfully,and 8 cases (15.1％) died.Among the 8 patients,3 died of severe craniocerebral injury,2 cases died of MODS and sepsis,and 1 cases died of shock.Fifteen cases of primary thoracic and abdominal trauma patients with DCS after treatment were cured and discharged,among which PCT in the treatment of 2 d increased only at the beginning then gradually reduced after.CRP,IL-6 and IL-10 all showed a trend of decline.Compared with 7 d and 1 d,significant difference was shown (P＜0.01).Conclusion By clearly knowing the clinical characteristics of severe MT,accurate diagnosis should be made to avoid misdiagnosis.At the same time,we should pay more attention to the emergency treatment and the treatment of fatal injury.

OBJECTIVE:To promote the development and make full use of the pharmacoeconomics(PE)in China.METHODS:The problems to be able to solved using PE,i.e the necessity of developing PE in China was discussed,and the bottleneck which will restrain or hinder the optimal utilization of PE was pointed out.RESULTS:We should strengthen the cultivation of talents engaged in PE,formulating guidelines of pharmacoeconomic evaluation and gradually apply PE into National Essential Medicine Policy.CONCLUSION:The decision-makers of health policy should have a sufficient understanding of PE so as to facilitate the utilization and sustainable development of PE in health policy-related decision-making.

OBJECTIVE: To discuss how to apply pharmacoeconomic evaluation in guiding drug pricing so as to make the drug pricing more scientific and reasonable. METHODS: The problems that pharmacoeconomic evaluation can solve in drug pricing, i. e. the necessity of the application of pharmacoeconomic evaluation were pointed out, and the costs and profits of drugs were evaluated pharmacoeconomically from the perspective of the whole society. RESULTS & CONCLUSION: Pharmacoeconomic evaluation can be utilized to determine the price ranges of new drugs, guide drug pricing and enhance the rationality of drug pricing.

The author first analyses the developing tendency of international higher education in 21 century whichbrings some challenges, such as popular target, varied pattern, and so on; then advances 6 pieces of correspondingcountermeasures:narrowing the gap between supply and demand,optimizing the structure of admimstrative offices,rear-ranging the disposition of resources, standardizing the management system,carrying out the distinctive strategies andgoing right into the international market.

Biosafety cabinets(BSC)is the primary containment barrier.It is very important to choose suitable control method for the protection ability of biosafety cabinet.This paper briefly introduces the key points and several control methods as well as the different characteristics of BSC control.

Objective By givng patients psychological nursing,attributing them to cooperation in the examination,perfect images and the correct diagnosis can be obtained. Methods Explaining the knowledge of the equipments and the examination, broadcasting videos ,improving the environment of the waiting-room,and telling the family the details of examination, can reduce or eliminate mental burden of the patients. Results 98% of the patients' mental burden are relieved. Conclusion Knowing patients' informations carefully is the key of the mental nursing. Every patient has different experience,background, the width of knowledge and the details of the examination. Different plans on psychological nursing based on that lead to satisfying results.

Objective To prepare a targeted ultrasound micro bubble,which carried the HSV-TK gene,and investigate the in vitro target searching ability of the micro bubbles and inhibitory effect on the proliferation of HepG2 cells.Methods Ultrasonic micro bubbles were prepared by mechanical vibration method,construction of targeted HSV-TK ultrasound micro bubbles by biotin affinity bridge construction.To detect the general characteristics of ultrasound micro bubbles,and to test its effect on the proliferation of HepG2 cells in vitro.Results HSV-TK targeted ultrasound microbubbles more gathered on the surface of HepG2 cells,through detection of PCNA and MTT,it was found that the proliferation of gene targeting microbubble group was obviously decreased,cell apoptosis increased significantly,Cells invade experiments showed that the number of cells in genetic microbubble group (22.18 ± 2.01) decreased significantly compared with the control group and the nontargeted group,can effectively inhibit the proliferation and invasive ability of HepG2 cells.Conclusion Targeted ultrasound microbubble carrying target gene have better inhibitory effect on HepG2 cells in vitro.