1.Clinical characteristics of hospitalized cases of severe acute respiratory infection with laboratory-confirmed influenza and the risk factors analysis of influenza infection for children under 15 years old in ten provinces in China during 2009-2014.
Zhibin PENG ; Jun XU ; Zhao YU ; Qianlai SUN ; Lusheng LI ; Peng YANG ; Zhongyi JIANG ; Min KANG ; Xin XIONG ; Lei LIU ; Yuwei WENG ; Guozhong ZHU ; Linglin LIU ; Xu DONG ; Huiqiong PAN ; Zhaolong CAO ; Haisen LIN ; Hua GUO ; Ling LI ; Hui JIANG ; Jiandong ZHENG ; Zhen XU ; Luzhao FENG ; Hongjie YU ; Email: YUHJ@CHINACDC.CN.
Chinese Journal of Epidemiology 2015;36(3):210-215
OBJECTIVETo identify clinical characteristics of hospitalized laboratory-confirmed influenza cases of children under 15 years old, and their risk factors of influenza infection.
METHODSAnalyzing the reports of hospitalized laboratory-confirmed influenza cases of children under 15 years old who were detected by the sentinel surveillance systems in 10 provinces from December 2009 to June 2014. Such data as their demographic, medical history, clinical symptoms and signs, treatment and outcome were collected using questionnaires, with their clinical characteristics and their risk factors of influenza infection described.
RESULTSOf the 2 937 severe acute respiratory infection inpatients, 190 (6.5%) were laboratory-confirmed influenza cases. 123 (64.7%) of such confirmed cases were male, and 139 (73.2%) were children under 5 years old, with age median of 3.0 years (IQR: 1.0-5.0 years). 20 (10.5%) of them had at least one chronic medical condition, mostly chronic cardiovascular disease (3.2%), immunosuppressive disease (3.2%), and cancer/tumor (2.6%). Most common clinical symptoms of the cases were fever (92.6%) and cough (88.8%), of which abnormal pulmonary auscultation (51.1%) and abnormal chest X-ray performance (36.1%) were the most common clinical signs. 29 cases (15.8%) had complications, of which pneumonia (15.3%) was most common. 16 cases (8.6%) used antiviral drugs, and 4 cases (2.2%) were admitted into ICU. Risk factor analysis suggested that age < 6 months (OR = 0.406, 95% CI: 0.203-0.815) was a protective factor against influenza infection; and age 5-9 years old (OR = 2.535, 95% CI: 1.059-6.066) was a risk factor for influenza infection.
CONCLUSIONHospitalized laboratory-confirmed influenza cases were found mostly in children under 5 years old. Risk exposure for influenza infection varied among age groups.
Acute Disease ; Adolescent ; Antiviral Agents ; Child ; Child, Preschool ; China ; epidemiology ; Cough ; Female ; Fever ; Hospitalization ; Humans ; Influenza A Virus, H1N1 Subtype ; Influenza, Human ; epidemiology ; pathology ; Inpatients ; Laboratories ; Male ; Protective Factors ; Risk Assessment ; Risk Factors ; Sentinel Surveillance ; Surveys and Questionnaires
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