micro RNA (miRNA) is the fragment of non-coding small RNAs and consists of 21-25 ribonucleotide.It can regulated gene expression by either binding to or regulating the translation process of some specific mRNA. This paper summarized the characteristics of miRNA, as well as its production, mechanism of action and functions.

0.05). Conclusion Combined inplantation of different types of DES is safe and does not increase the incidence of MACE.

Objective To compare the long term outcomes of delayed or primary percutaneous transluminal coronary intervention(PCI) with concervative drug therapy for acute myocardial infarction(AMI).Methods The data of 276 patients with AMI hospitalized during January 1996 to October 2003 were analyzed retrospectively.The patients were divided into three groups including: primary PCI group(75 cases underwent primary PCI within 12 hours of symptom onset),delayed PCI group(73 cases underwent delayed PCI after 24 hours symptom onset) and conservative drug therapy group(128 cases without PCI treatment).Major adverse cardiac events(MACE) were recorded during the follow-up period(mean 4.3?2.7 years).Echocardiography was carried out and long-term mortality rate was recorded during follow-up.Results The Baseline characteristics of the three groups were similar except elevation in ST segment and in-hospital duration which were significantly different in the primary PCI group.The percentage of follow-up completion was 89.5%(247/276).The in-hospital mortality of the conservative therapy group was higher than both PCI groups.The LVEF of the delayed PCI group,primary PCI group and the conservation therapy group were 57.4%?3.4%,59.3%?7.5% and 54.7%?4.1% respectively.There was 1 deceased case in both the delayed and primary PCI group but 14 cases in the conservative group.There was no significant difference between the two PCI groups in terms of combined end point of death and clinical events different.Conclusion Compared with conservative drug therapy,delayed PCI can further improve the long-term prognosis of STEMI patients.

Object To study the chemical constituents of Pueraria omeiensis Tang et Wang. Methods Isolation and purification were repeatedly carried out on silica gel column chromatography, Sephadex LH-20, and preparative HPLC. The structures were identified and elucidated by physicochemical properties and spectral analysis. Results One compound was elucidated as sophoracoumestan A (Ⅰ) from the acetic ether section, and 15 compounds were obtained from the n-butanol section. They were ononin, (Ⅱ), daidzein 7,4′-diglucoside (Ⅲ), daidzein 7,4′-glucoside (Ⅳ), 3′-methoxy puerarin, PG-3 (Ⅴ), 3′- hydroxypuerarin, PG-1 (Ⅵ), mirificin (Ⅶ), 8-methyl retusin 7-O-glucoside (Ⅷ), daidzein (Ⅸ), daidzin (Ⅹ), genistin (Ⅺ), puerarin ( ⅩⅡ), octacosanoic ( ⅩⅢ), allantoin ( ⅩⅣ), glycerol 1-monopentacosanoate ( ⅩⅤ), daucosterol, ⅩⅥ), respectively. Conclusion Besides compounds Ⅸ- ⅩⅡ, ⅩⅥfrom the acetic ether section, the others are first obtained in P. omeiensis, and compounds Ⅰ, Ⅳ, Ⅷ are found in the plants of Puerarea DC. for the first time.

0.05) after SVT episode. Compared to the SVT group and basic status, the extraction ration of glucose and oxygen of CAD patients obviously increased( P

Objective To study the constituents of Abrus mollis.Methods The constituents were isolated by chromatographic methods,their structures were elucidated by spectroscopic evidences.Results Eleven compounds were purified and their structures were identified,they were identified as ?-sitosterol(Ⅰ),stigmasterol(Ⅱ),nonacosanyl caffeate(Ⅲ),daucosterol(Ⅳ),betulinic acid(Ⅴ),vanillic acid(Ⅵ),inositol methyl ether(Ⅶ),sucrose(Ⅷ),soyasaponin Ⅰ(Ⅸ),kaikasaponin Ⅲ(Ⅹ),and dehydrosoyasaponin Ⅰ(Ⅺ).Conclusion Compounds Ⅰ,Ⅲ,Ⅳ,Ⅵ,and Ⅶ-Ⅺ are isolated from this plant for the first time.

Objection To compare the efficacy and tolerance of perioperative intravenous Metoprolol or calcium iron antagonist injection on patients with cardiac complications which undergoing noncardiac surgery. Method The clinical data of 135 patients who underwent noncardiac surgery from March 2003 to May 2004 was analyzed. According to the different drugs used to treat the perioperative cardiac complications (tachycardia arrhythmia, hypertension and myocardium ischemia), patients were allocated to metoprolol group (87 cases) and calcium antagonist group (48 cases, including Verapamil 21 patients and Diltiazem 27 patients). The effects of the therapy on heart rate and blood ressure control and ischemia relieving were compared between two groups. Results There is no significant difference at baseline data between two groups. Compared with calcium antagonist, intravenous metoprolol could more reduce heart and relieve myocardium ischemia quickly. The effect of blood pressure controlling was more significant in calcium antagonist group than in metoprolol group. The incidence of side-effects events was lower in metoprolol ( 8.0%) than in calcium antagonist group (22.9%).Conclusions Intravenous metoprolol injection is effective and safe in treating perioperative cardiac complications in patients with noncardias surgery.

Objective To study the effect of Depside Salt from Salvia Miltiorrhiza on angina pectoris and platelet function.Methods The study group was comprised of 56 patients with stable angina,who were randomly divided into the high-dosage Depside Salt from Salvia Miltiorrhiza group,the low-dosage Depside Salt from Salvia Miltiorrhiza group and the Danshen control group. Before and after the 14-day treatment,the clinical symptom and serum level of PAG, P-selectin were measured,and exercise electrocardiography was performed. Results After treatment with Depside Salt from Salvia Miltiorrhiza,the symptom of angina pectoris was alleviated and exercise ECG was improved,while no significant difference was found compared with control group.Serum PAG and P-selectin were decreased after treatment with Depside Salt from Salvia Miltiorrhiza ,and significantly more than Danshen.Conclusion Depside Salt from Salvia Miltiorrhiza injection can remarkably inhibite the aggregation and activation of platelet,and is effective for angina pectoris.

Objective To compare the effects of clopidogrel and ticlopidine in combination with aspirin in preventing direct coronary stenting complication in patients with acute myocardial infarction.Methods The clinical data of 74 cases with ST-segment elevation myocardial infarction were retrospectively analysed. The patients were divided into two groups. Before direct coronary stenting, clopidogrel,300mg loading dose then 75mg once daily or ticlopidine 250mg twice daily in addition to aspirin 100mg once daily were given to two groups respectively. Hemorrhage, neutropenia, thrombocytopenia were observed during 4 weeks. The frequency of clinical cardiovascular events (including cardiac mortality, myocardial re-infarction, need for revascularization) were followed up at 6 months. Results The incidence of major cardiac events in clopidogrel group was less than ticlopidine group ( 21.1% with Clopidogrel and 44.4% with Ticlopidine,P= 0.031). The incidence of light hemorrhage patents individually were 6(15.8%) vs 14(38.9%). The mean number of neutrophile white celll individually were 5.8 ?1.7 vs 4.2 ?3.6 (?10 9/L). The platelet count were 130.3 ?42.1 vs 89.2 ?53.3(?10 9/L), P

OBJECTIVE: To study the constituents of the subaerial of Saussuare deltoidea (DC.)C. B. Clarke. METHODS: The constituents were separated by column chromatography on silica gel and the structures were elucidated by spectroscopic means. RESULTS: Eight constituents were identified to be Luteolin(Ⅰ), Quercetin(Ⅱ), Quercetin 3 0 ? L rhamnopyranoside(Ⅲ), rutin(Ⅳ), Lupeol acetate(Ⅴ), Lupeol(Ⅵ), ? sitosterol (Ⅶ), and Daucosterol(Ⅷ).CONCLUSION: Compounds Ⅰ Ⅷ were obtained from S.deltoidea for the first time.