Hailey-Hailey Disease (HHD) is a rare, chronic skin condition characterized by relapsing episodes and spontaneous remissions, significantly affecting patients’ quality of life, especially in severe cases. Due to its rarity, there are no established evidence-based treatment guidelines or extensive clinical trials. This case report highlights the rapid improvement of HHD in a 55-year-old Filipino woman treated with a combination of 5-fluorouracil and excimer phototherapy, suggesting that this treatment approach may be an effective alternative for managing the disease.

No abstract available.
Dihydroxycholecalciferols ; Pemphigus, Benign Familial

No abstract available.
Cryotherapy* ; Pemphigus, Benign Familial*

No abstract available.
Codon, Nonsense* ; Pemphigus, Benign Familial*

Pemphigus, Benign Familial ; Case Report

Humans ; Pemphigoid, Bullous ; Pemphigus ; Pemphigus, Benign Familial

No abstract available.
Aminolevulinic Acid* ; Pemphigus, Benign Familial* ; Photochemotherapy*

Hailey-Hailey disease (HHD) is an uncommon acantholytic disorder of the skin. This is a case of a 64-year-old Filipino female with a chronic history of painful and malodorous intertriginous plaques. Histopathologic evaluation showed overlapping features of pemphigus vulgaris and Hailey-Hailey disease. A negative direct immunofluorescence test clinched the diagnosis of Hailey-Hailey disease. The patient was advised regarding preventive measures and treated with topical antibiotics and corticosteroids with improvement of her lesions.
Pemphigus, Benign Familial ; Fluorescent Antibody Technique, Direct

A solitary acantholytic acanthoma is a benign tumor which presents as a solitary asymptomatic, keratotic papule or nodule. The acantholysis, implied in the term, is the histologic hallmark. It may mimic pemphigus vulgaris, pemphigus vegetans, or Hailey-Hailey disease, but displays no evidence of these disorders. We report a case of isolated acantholytic acanthoma in a 78-year-old man, where the histologic feature is focal acantholytic dyskeratosis.
Acantholysis ; Acanthoma* ; Aged ; Humans ; Pemphigus ; Pemphigus, Benign Familial

Acantholytic acanthoma is typically an asymptomatic, keratotic papule or nodule. In 1988, Brownstein described a previously unrecognized benign acanthoma, the acantholytic acanthoma. The term acantholytic is used because acantholysis is the outstanding histologic feature in this neoplasm; acanthoma is chosen because the growths are benign tumors of epidermal keratinocytes. On histopathology, these tumors may mimic pemphigus vulgaris, pemphigus vegetans, superficial pemphigus, or Hailey-Hailey disease, but had no evidence of any of these disorders. We report a case of acantholytic acanthoma seen on the inguinal area of a 79-year-old man who had a keratotic nodule on the left inguinal area.
Acantholysis ; Acanthoma* ; Aged ; Humans ; Keratinocytes ; Pemphigus ; Pemphigus, Benign Familial