Intestinal motility disorders,one of the common complications of critically ill patients,can be caused by a variety of diseases.It was reported that intestinal motility disorders could be improved by modulating the micro-ecological environment in the distal digestive cavity and by reducing the bacterial toxins,and thereby it provides a new reference strategy for the treatment of intestinal motility disorders.Dictary fiber has physiological functions such as accelerating colonic transition,regulating the intestinal microflora and protecting the intestinal mucosal barrier.Clinically,dietary fiber is used as an adjuvant therapy of intestinal motility disorders widely in critical illness,inflammatory bowel disease and diabetes.In order to explore the relationship between the application of dietary fiber and the improvement of intestinal motility disorders,we retrieved the Chinese and English databases and summarized sone recent literatures for providing new ideas for the prevention and treatment of intestinal motility disorders.

0.05).Significant difference was found between group ④ and ①,②,③ or ⑤(P

Objective:To evaluate the characteristics of bonding interface and microstructure of different resin composite inlays. Methods:Different composite resins and adhesives were used for restoration of extracted molars, the results were evaluated under scanning electron microscope(SEM) and atomic force microscope(AFM).Results:The microstructure feature of Tescera was with higher density when compared with that of other conventional resins,and fewer small holes could be seen in Tescera. AFM pictures showed that Tescera was with a very smooth surface. Indirect composite resin could be combined with resin bonding agent tightly and infiltrated each other. The interface between direct resin inlay material and resin bonding agent was very clear,and no obvious interfiltration could be seen under SEM and AFM. Conclusion:After treatment with water, heat,light and pressure, the physical properties of indirect composite resin is improved effectively, and obvious infiltration can be found in the interface.

Objective:To investigate the distribution and content of transforming growth factor-β1 (TGF-β1)and vascular endothelial growth factor (VEGF)in concentrated growth factors (CGF)gel, and to clarify the difference among different layers of CGF.Methods:Venous blood samples were col-lected from 6 healthy volunteers to prepare CGF.The distribution,integrated optical density (IOD)and average optical density (AOD)of TGF-β1 and VEGF in CGF gel and red blood cell (RBC)layer were measured using immunohistochemistry.The concentrations of TGF-β1 and VEGF in the supernatant se-rum at baseline and the CGF releasate after 1 day were evaluated with enzyme-linked immunosorbent as-says.Results:Abundant TGF-β1 and VEGF were concentrated in CGF gel.However,only a little could be found in polykaryocytes and sporadic platelets in RBC layer.Platelets and leukocytes were concentra-ted in between the two layers with high expression of TGF-β1.The concentrations of TGF-β1 and VEGF in the CGF releasate(55 236.78 ±3 686.34),(610.99 ±148.81)ng/L were significantly higher than those in the supernatant serum (20 710.20 ±4 523.14),(335.20 ±51.69 )ng/L (P <0.001 ). Conclusion:CGF contains high quantities of TGF-β1 that can promote new bone formation and tissue healing.We suggest that CGF gel should be used right after being prepared.Supernatant serum and the area between CGF gel and RBC layer could also be mixed with bone substitute materials.

Objective:To make a within-subject comparison of masticatory function and pattern between complete denture(CD)and implant-supported overdneture(IOD).Methods: Three edentulous patients volunteered to take part in this test.Each of the patients was rehabilitated with lower CD first and lower IOD later,and with the upper denture of CD.The masticatory efficiency,mandibular movement trace and the surface electromyograph (EMG) of masseters,anterior temporlis and posterior temporlis were measured 3 month after the use of each set of the dentures.Results: With IOD,each patient increased masticatory efficiency,especially when chewing almond.The regulation of chewing cycle,centralization of end traces and occlusal slides of mandibular movement were significantly improved.The electricactivity of masseters,anterior and posterior temporlis all enhanced by means of increasing contract intensity and the rhythm of the mastication was more regular.The muscle activity pattern in two cases transformed from instable to stable,while that of the another patient changed from masseter preponderant pattern to temporlis preponderant pattern.Conclusion: Patients with IOD have a heigher masticatory efficiency,more regular mandibular movement pattern,more effective masticatory muscle contractive pattern and masticatory muscle coordinative pattern than those with CD.

This paper is aimed to develop a computerized three dimensional system for displaying and analyzing mandibular helical axis pathways. Mandibular movements were recorded using a six-degrees-of-freedom ultrasonic jaw movement recording device. The three-dimensional digital models of the midface and the mandible were reconstructed and segmented from CT skull images. The digital models were then transformed to the coordinate system of mandibular motion data by using an optical measuring system. The system was programmed on the base of the Visualization ToolKit and Open Scene Graphics Library. According to the motion data, transformation matrices were calculated to simulate mandibular movements. Meanwhile, mandibular helical axis pathways were calculated and displayed three dimensionally by means of an eigenvalues method. The following parameters of mandibular helical axis were calculated: the rotation around instantaneous helical axis, the translation along it, its spatial orientation, its position and distance relative to any special reference point. These parameters could be exported to describe comprehensively the whole mandiblular movements. It could be concluded that our system would contribute to the study of mandiblular helical axis pathways.
Humans ; Imaging, Three-Dimensional ; Mandible ; Models, Anatomic ; Movement ; Rotation

The body is exposed to various organic anions,so it is the best way to remove the toxic substances in the body quickly and effectively.Cross epithelial active transport mediated by organic anion transporter is the rate limiting process.Renal secretion and re-absorption of a variety of endogenous and exogenous organic anions are occurred in the proximal tubular epithelial cells of the organic anion transporter family.The expression of organic anion transporter-1 (OAT1) in proximal tubular epithelial cells plays an important role in the introduction of organic anion into the renal tubular epithelial cells.This article reviewed the renal expression,the substrate and the polymorphism of the organic anion transport protein OAT1,the renal toxicity of adefovir dipivoxil,the interaction between organic anion transporters and drug,and the influence of the renal toxicity on the renal toxicity of adefovir dipivoxil.

Objective:To analyze occlusal contact areas on the working and nonworking sides during unilateral mastication.Methods: Eighteen subjects without any temporomandibular disorder(TMD) symptoms participated in the present study.The subjects were presented with 3 g gum for right masticating.Chewing movement was simulated using virtual craniofacial movement simulation system.Then occlusal contact areas were calculated at four selected moments during the closing phase in the third chewing cycle: the occurrence of occlusal contact,one third time,two thirds time,the intercuspal occlusion.Results: During the closing phase in the third chewing cycle,the total occlusal contact areas on working side increased from(9.3?0.4) mm2 to(39.2?1.2) mm2,and that on nonworking side increased from(2.3?0.5) mm2 to(40.3?1.2) mm2.At the occurrence of occlusal contacts,occlusal contact areas of the first and second mandibular molars were on average(3.7?0.2) mm2 and(3.5?0.2) mm2 on working side,and(0.5?0.2) mm2 and(1.2?0.3) mm2 on nonworking side,respectively.However,when the mandible moved to the intercuspal position,their areas were sharply increased to(14.8?0.7) mm2 and(13.9?0.4) mm2 on working side,and(13.6?0.5) mm2 and(12.1?0.5) mm2 on nonworking side,respectively.In addition,nonworking-side contacts were observed for 12 subjects at the occurrence of occlusal contacts,and for all subjects at two thirds time.Conclusion: This paper provides a new method useful for analyzing occlusal contacts during functional movements.This study revealed the pattern of occlusal contacts during the closing phase in the chewing cycle.Moreover,it was confirmed that nonworking-side contacts occurred during unilateral mastication.

Objective To compare the concordance among RECIST, EASL and modified RECIST criteria for the evaluation of tumor response after transarterial chemoembolization of primary liver cancer.Methods Fifty patients with primary liver cancer underwent 2 TACE cycles separated by 30-40 days.Triphasic helical CT or MRI scans were performed at baseline, at 4 weeks after TACE procedure, and 2 independent radiologists evaluated tumor response according to above-mentioned three different criteria. Chisquare test was used to compare the response rate, and kappa coefficients were used to evaluate the coherence. Results When tumor responses were evaluated using the RECIST-EASL and modified RECIST criteria, the numbers of the patients achieved complete response, partial response, stable disease,progressive disease were 0, 10, 30, 10; 6,21,14,9; 6,21,13,10 respectively. The objective response rates for three different criteria were 20%, 54%, 54% respectively ( P ＜ 0. 01 ). Kappa coefficients between RECIST and EASL, between RECIST and modified RECIST, between EASL and modified RECIST were 0. 382, 0. 170, and 0. 857 (P = 0. 000). Conclusions RECIST criteria underestimates the extent of tumor response after TACE in primary liver cancer. Both EASL and modified RECIST criteria appear to agree with each other in determining treatment response. Furthermore, the modified RECIST is more convenient in clinical practice compared with EASL criteria.

Objective To explore the prevalence of age-related eye diseases (AREDs) among people aged 70 years or above in Hangzhou and evaluate the impact of AREDs on visual function (VF) and visual-related quality of life (QOL) in elders.Methods This study involved a total 2 111 elderly people (≥70 years).All participants received visual acuity and comprehensive eye examinations and complete VF and QoL questionnaires.Results The main cause of visual impairment was AREDs.And the causes were age-related cataract (79.82％),AMD (45.64％),glaucoma (10.95％) and diabetic retinopathy (DR,7.30％).VF and QoL scores declined gradually with age.And the scores declined more rapidly with declined visual acuity among the elders.VF and QoL scores in patients with age-related cataract,AMD,glaucoma and DR were successively lower.After adjusting for age,gender and visual acuity,the elders with AREDs had lower scores across all domains of VF and QoL.Scores for subscales of VF and QoL domains were significantly lower among those with DR and glaucoma compared with those with age-related cataract and AMD.Conclusion Age,presenting vision and AREDs are associated with VF and QoL in this elderly population.And senile people with glaucoma and DR have severe declines in VF and QoL,independent of presenting visual acuity.