Objective:To investigate the efficacy of continuous irrigation and drainage combined with lesion debridement surgery in the treatment of purulent bone and joint infections in children.Methods:A case-control study was conducted to retrospectively analyze the clinical data of 76 children with purulent bone and joint infections who received treatment at Hangzhou Children's Hospital from January 2021 to October 2022. Based on different treatment methods, these children were divided into a control group and an observation group, with 38 cases in each group. The control group received lesion debridement surgery, while the observation group underwent continuous irrigation and drainage combined with lesion debridement surgery. The clinical outcomes of the two groups were compared.Results:The total response rate in the observation group was 97.37% (37/38), which was significantly higher than that in the control group [76.32% (29/38), χ2 = 7.36, P < 0.05]. After treatment, the white blood cell count, erythrocyte sedimentation rate, and percentage of neutrophils in the observation group were (4.32 ± 0.95) × 10 9/L, (14.20 ± 2.50) mm/h, and (52.12 ± 8.45)%, respectively, all of which were significantly lower than those in the control group [(5.68 ± 1.02) × 10 9/L, (22.35 ± 3.35) mm/h, and (66.65 ± 6.20)%, t = 6.01, 12.01, 8.54, all P < 0.05]. The levels of interleukin-6, C-reactive protein, procalcitonin, and tumor necrosis factor-α in the observation group were (5.20 ± 1.02) ng/L, (8.20 ± 1.11) mg/L, (0.80 ± 0.12) μg/L, and (3.20 ± 1.02) ng/L, respectively, which were significantly lower than those in the control group [(8.12 ± 1.10) ng/L, (14.34 ± 2.20) mg/L, (1.12 ± 0.20) μg/L, and (7.50 ± 1.12) ng/L, t = 11.99, 15.36, 8.45, 17.49, all P < 0.05). At 1 week, 1 month, and 3 months after treatment, the Visual Analog Scale scores in the observation group were significantly lower than those in the control group ( t = 3.14, 2.33, 11.36, all P < 0.05). The recurrence rate in the observation group was significantly lower than that in the control group [2.63% (1/38) vs. 21.05% (8/38), χ2= 4.53, P < 0.05). Conclusion:Continuous irrigation and drainage combined with lesion debridement surgery is more effective for treating purulent bone and joint infections in children than lesion debridement surgery alone. This combined therapy can more effectively reduce inflammatory responses, alleviate pain, and lead to a lower recurrence rate.

Objective To analyze the risk factors for extrauterine growth retardation(EUGR)in late preterm infants appropriate for gestational age.Methods The clinical data in 1 402 preterm infants appropri-ate for gestational age delivered and hospitalized in this hospital from January 2016 to June 2022 were analyzed retrospectively.They were divided into the EUGR group(n=244)and the non-EUGR group(n=1 158)ac-cording to whether or not the body weight at discharge was below the 10th percentile of the growth curve for the same gestational age at the same period based on the Fenton's preterm growth curve.The clinical data of preterm infants and mothers of the two groups were collected.The risk factors for EUGR occurrence in pre-mature infants were analyzed.Results Among 1 402 preterm infants appropriate for gestational age,EUGR occurred in 244 cases with the EUGR incidence rate of 17.4％.The EUGR incidence rate had no statistical difference among the different fetal ages of premature infants(P＞0.05).The EUGR incidence rate had sta-tistical difference among different birth weights of premature infants(P＜0.05).The logistic regression anal-ysis showed that male(OR=1.694,95％CI:1.144-2.507),low birth weight(OR=0.989,95％CI:0.988-0.991),feeding intolerance(OR=2.719,95％CI:1.234-5.990),short gestational weeks(OR=0.146,95％CI:0.103-0.207)and hospitalization duration extension(OR=1.073,95％CI:1.031-1.117)were the risk factors for EUGR occurrence in late premature infants appropriate for gestational age in discharge.The sub-group analysis showed that male,low birth weight,feeding intolerance and hospitalization duration extension were the risk factors for EUGR occurrence in the preterm infants with gestational ages of 34-＜36 weeks(P＜0.05).Low birth weight and feeding intolerance only affected the preterm infants≥36 weeks of gesta-tional age(P＜0.05).Conclusion Strengthening the pregnant duration health care and active nutritional sup-port after birth may reduce the risk of EUGR occurrence in late premature infants.