Objective To investigate the value of GPS score and CEA in predicting the prognosis of pa-tients with colorectal cancer undergoing laparoscopic surgery. Methods 120 patients diagnosed as colorectal can-cer in our hospital were involved and their baseline information include Height,weight,history,complication, course of disease,tumor size,pathological type,tumor location,TNM stage,vascular tumor thrombus and lymph node metastasis were recorded. Then,all of the patients were followed-up 18 months and patients with favorable prognosis were defined as the favorable group while patients with unfavorable prognosis were defined as the unfavor-able group. Cox′s proportional hazard regression model analysis was applied to evaluate the influencing degree of those factors on the prognosis of the subjects. The factors in predicting prognosis were calculated by ROC curves. Results The poor prognosis rate of patients with colorectal cancer after operation treatments was 37.84%. Cox′s proportional hazard regression model analysis showed that CEA(P = 0.035),GPS score(P = 0.023)have influenc-es on the prognosis. Conclusion GPS scores and CEA may assess the prognosis of patients with colorectal cancer undergoing laparoscopic surgery,which is expected to be used as an indicator of predicting the prognosis of pa-tients with colorectal cancer undergoing laparoscopic surgery.