Objective To discuss effect of intellectual training on cognitive function, daily life ac-tivity and life quality of patients with Alzheimer's disease. Methods We used clinical dementia rating (CDR) scale to selecf 38 patients with mild to median degree of Alzheimer's disease.Intellectual training was carried out for 1 year and at the same time their family members took part in it and dietary instruction was given. Mini-mental state examination (MMSE), information-memory-concentration test (IMCT) and activity of daily living scale (ADL) were used as evaluation tools before and after training. Results The patients' degree of defect before training was not different from that of within the first three months after training (P＞0.05),but greatly alleviated 6 months and one year later (P＜ 0.05,P＜ 0.01 ). Conclusions Beneficial intellectual training could improve the cognitive function of patients with Alzheimer's disease.It alleviated their symptom,prolonged the process of dementia and increase the living and life quality of them.

ObjectiveTo investigate the curative effect of recombinant bovine basic fibroblast gnowth factor (rbbFGF)in the treatment of senile diabetic foot ulcer and summarize the nursing methods.Methods 28elderly patients with senile diabetic foot ulcer were divided into the control group and the treatment group with 14 patients in each group.The control group was given medical treatment and local wound dressing change,the treatment group was given rbbFGF based upon the above method.The degree of granulation tissue maturity,wound healing time and therapeutic effects were compared between these two groups.The nursing measures were summarized.ResultsOn the 9th day and 13th day,granulation tissue maturity degree of the treatment group was better than the control group.On the 14th day,21th day and 28th day,endepidermis growth velocity of the treatment group was better than the control group.The wound healing time of the treatment group was (29.87±5.73) d and was significantly shorter than (38.49±6.58) d of thecontrol group.The therapeutic effect of the treatment group was better than that of control group on the 28th day.ConclusionsApplication of rbbFGF has good curative effect on senile diabetic foot ulcer and suitable nursing care methods contributes to recovery of elderly patients.

Objective To study the cognitive behavior and intervention therapy for elder patients to preventing tumble. Methods 156 elder patients were selected in intervention group,which have accepted the cognitive behavior and intervention therapy.155 elder patients were selected in control group,they have not accepted this therapy.Compared the results of these 2 groups. Results (99.72%) patients in interevention group have mastered the knowledges of preventing tumble,which was significant higher than the 66.40% in control group(P

[ ABSTRACT] AIM:To compare the differences of the genome-wide methylation levels and methylated regions be-tween nasopharyngeal carcinoma ( NPC) cells in the same genetic background but different radiation resistance ( CNE-2 cells and CNE-2R cells).METHODS:Using the method which was developed by Doctor Zhao Cun-you, based on using methyl-sensitive restriction enzyme to measure the genome-wide methylation levels.In addition, MeDIP-Seq was used to analyze the methylated regions in 6 gene functional elements, including the upstream 2k sequence, 5’ UTR, coding se-quence, intron, 3’UTR and downstream 2k sequence, between CNE-2 cells and CNE-2R cells.RESULTS:The genome-wide methylation level was approximately 30%lower in CNE-2R cells than that in CNE-2 cells.No obvious difference on the amount of genes and the coverage of the peak in the 6 gene functional elements was observed.However, the methylation pattern of plentiful genes had altered in the gene function elements.CONCLUSION:The genome-wide methylation levels and methylated regions between NPC cells in the same genetic background but different radiation resistance were quite dif-ferent, indicating that the DNA methylation may be associated with NPC radioresistance.