Objective To analyze the clinical efficacy of improved incision septoplasty in treatment of allergic rhinitis and its effect on the life quality of patients.Methods A total of 42 patients with persistent allergic rhinitis and merge nasal septum in our hospital from July 2013 to April 2015 were divided into observation group and control group.The observation group were treated by improved incision septoplas-ty,and the control group received traditional KillIan incision treatment.The clinical efficacy,survival quality and visual analog scale between two groups were compared.Results After treatment,The total efficiency rate of observation group(94.24%)was significantly higher than that of control group(85.71%)(χ2 =7.15,P <0.05).The nasal congestion,nasal itching,sneezing and other symptoms score of observa-tion group were significantly lower than those of control group(P <0.05).The score of nasal problems,eye problems,eye problems and non-nasal sleep disorders in observation group were also significantly lower than those in control group(P <0.05).Intraoperative situation of ob-servation group was significantly better than that of control group(P <0.05).Conclusion Improved incision septoplasty has a good clinical efficacy for patients with persistent allergic rhinitis and merge nasal septum,which can significantly improve the clinical symptoms and life quality of patients.

In recent years,the influencing factors of prognosis and effect after radiotherapy in breast cancer patients with radical mastectomy or modified radical mastectomy have gradually become a hot research,and it is closely related with the stages,subtypes,hormone levels and the body mass index (BMI).Otherwise,from three dimensional conformal radiation therapy to helical tomotherapy,the development of radiation technology has a breakthrough progress and makes the treatment of diseases more accurate and rational.

Forty-eight male Wistar rats,weighing 280 to 320 g,were selected and prepared by fasting but free drinking for 12 hours before the experiment.They were randomly divided into four groups by random number table (12 rats in each group):control group,ischemic group,reperfusion group and propofol group.Control group:normal saline infusion[10 ml /(kg?h)]for 1 h in caudal vein without any other treatment.Ischemic group:on the basis of control group,supply with 20 mmHg(1 mmHg =0.133 kPa)pneumoperitoneum pressure for 1 h. Reperfusion group:on the basis of ischemic group,keep pneumoperitoneum pressure open for 30 min.Propo-fol group:infusion propofol in caudal vein [10 ml /(kg?h),saline 10-fold dilution],given 20 mmHg pneu-moperitoneum pressure for 1 h,then kept this pressure open for 30 min.The expression changes of blood urea nitrogen(BUN),creatinine(Cr),superoxide dismutase(SOD),malondialdehyde(MDA)and nuclear factor E2-related factor 2(Nrf2)were detected individually.Results The levels of BUN,Cr and MDA gradually increased,while the level of SOD decreased in control group,ischemic group and reperfusion group (P ﹤0.05,respectively).Compared with ischemic group and reperfusion group,the levels of BUN,Cr and MDA decreased significantly,and the level of SOD increased markedly in propofol group(P ﹤0.05,respectively). The expression of Nrf2 protein and mRNA gradually increased in the control group,ischemia group,reperfu-sion group and propofol group (P ﹤0.05).Conclusion Carbon dioxide pneumoperitoneum can cause renal IRI in rats.Propofol has a protective effect of IRI by regulating the expression of Nrf2 protein.

Schisandra is a frequent traditional Chinese medicine. It has the efficacy of SHOULIAN-GUSE, YIQING-SHENGJING, tonifying kidney and Ning heart, is very important tonic medicine. Patent literature records the majority of technological innovations, is a kind of valuable scientific literature, making good use of it can effectively promote innovation. And invention patent is the most valuable of all patent. Access to information found that there is no paper about analysis of schisandra related pantent in China. Thus, in this paper, Schisandra related patents were collected, statistics, analysis, to discover the information within, such as Schisandra patent history, the current pattern, outstanding invention agencies and drug law of Schisandra. Based on the result above, we hope to provide a reference for the patent application.

With the increase of Chinese people's material life level, their health consciousness has become more and more intense. Chinese Materia Medica, a treasure of Chinese medicine, has made a great contribution in maintaining people's health in the history. Patent is a kind of high-value scientific literature. In this paper, we retrieved the patents of the traditional medicines used in health care worldwide. The patents were further screened by a series of processes. Finally, multi-angle analysis was carried out on the dataset to form a patent analysis report of traditional medicines in health care, including the distribution of the patents, the application trends, the domestic and foreign geographical layout, the major applicant and its activity, the important technical areas, the important medicinal and its pharmacological properties and so on.

Depression is a common mental disorders, severe cases may affect people's lives. In the treatment of de-pression, appropriate medication, as an assistant approach to psychological support, is proved helpful to patients' re-covery. Western medicine's ingredients are simple and mechanism is clear. Given it meets parts of the demand, the total effect is not satisfactory yet. Traditional Medicine's advantage is systematic, it has advantage in treating complex diseases. Thus, more and more attention was paid to Traditional Medicine, especially Traditional Chinese Medicine (TCM). In this paper, we use patent as data source to discover the law of the TCM's usage, the international differ-ences, the outstanding organization, and the hotspots of the drug research in the treatment of depression. Profiling of the current status can provide references in new drug finding and the progress of pharmacy. The results show that there are a few traditional Chinese medicine patents about treatment of depression associated with kidney, but de-pression and kidney also have a higher correlation. Medicines within soothing liver formulas such as Xiaoyaosan have many related patent.

A . Senticosus is a common medicinal plants, mainly used parts are the dried roots, rhizomes and stems. Since ancient time, it has been regarded as one of top grade medicabecause of its safety and various medicinal properties. To further the development and utilization, a survey of patent information is very helpful to outline the current status of the drug. In this paper, Espacenetand World Traditional Medcine Patent Database were used to perform patent retrieval. Then the dataset were screened, standardized and analyzes via Python and R. The result indicates that, A . Senticosus, given being used for a long history, has less invention patents application comparing with other TCM drugs. The applications mainly come from China, Korea, Japan, Russia, and USA. The major functions includes systemic protection, anti-toxic agent, and treatments of nervous system, digestive system, metabolic, immune and allergic diseases. As to the compatibility of medicines, it often associated with tonic medicine, especially Buqi medicine.

BACKGROUND:Elderly patients with femoral neck fractures have poor regulatory mechanism, accompanied by a variety of comorbidities and complications, so the treatment and rehabilitation of perioperative femoral neck fracture is very important.
OBJECTIVE:To review the prosthesis selection and complication treatment in perioperative femoral neck fracture in elderly patients.
METHODS:A computer-based research was conducted in PubMed database and CNKI database for the articles published since 2000, the key words were“elderly, femoral neck fracture, perioperative, treatment and rehabilitation, hip fracture”in Chinese and English. The clinical researches were selected. The subjects were the femoral neck fracture patients with the age over 65 years. The review literatures and the literatures with smal cases and old were eliminated, and final y 20 literatures were included for analysis.
RESULTS AND CONCLUSION:Due to the osteoporosis of the elderly patients, the internal fixation often failed. For the Garden Ⅲ and Ⅳ femoral neck fracture patients with the age over 65 years, as long as there is no clear contraindication for surgery, the hip replacement is often used for the treatment. The tolerance of the patients should be accurately evaluated before replacement, and the blood pressure, blood glucose and various medical complications should be control ed;the rehabilitation training after replacement is also essential. The common complications in elderly patients after replacement include stress ulcer, deep venous thrombosis, neuropsychiatric symptoms, urinary tract infections and the surgical infection.

Objective To investigate the effect of erythropoietin on hemorrhage in hip replacement surgery .Methods 48 cases undergoing elective hip replacement surgery in our hospital From June 2014 to October 2016 were selected and devided into control group and experimental group according to the conditional similarity, 24 cases in each group, then the application of erythropoietin in hip replacement surgery was explored.For the experimental group, erythropoietin was injected subcutaneously at three, five and seven days before operation, the dose was 250 U/(kg· times).The control group received 0.9%sodium chloride injection of the same volume of saline, and the other treatments were the same as in the experimental group.Preoperative situation, hemoglobin (Hb) levels, blood pressure (diastolic pressure and systolic blood pressure) at one day before surgey and three, seven and 14 days after surgey were compared and analyzed.Results There were no significant difference in body weight, hemoglobin (Hb), and age between the two groups before operation.The levels of Hb in the experimental group and the control group at 3 and 7 days after operation were compared, the difference was statistically significant (P<0.05), 14 days after the surgey, Hb returned to normal in the experimental group, while the Hb level in the control group was still significantly lower than that in the control group before surgey, the difference was statistically significant (P<0.05).There was no significant difference in diastolic blood pressure and systolic blood pressure between the two groups.Conclusion Preoperative erythropoietin mobilization in patients with hip replacement surgery can reduce the amount of bleeding during and after operation , and the adverse reactions are not obvious.

AIM: To investigate the mutatation type and polymorphism site in the ?-L-iduronidase (IDUA) gene of Liaoning district MPS-I patients. METHODS: The mutation type and polymorphism site in the IDUA gene of Liaoning district mucopolysaccharidosis type I (MPS-I) patients were detected by PCR-SSCP and DNA sequencing. RESULTS: ① 2 new mutations: R363H, 880+g-c in the IDUA gene of Liaoning district MPS-I patients were found. ② There were 3 polymorphism sites: R105Q、L118 and A361T in the IDUA gene of Liaoning district MPS-I patients. CONCLUSIONS: The mutation type in the IDUA gene of Liaoning district MPS-I patients is different from that of other countries and districts, while the polymorphism site in the IDUA gene of Liaoning district MPS-I patients is the same as that of other countries. [