OBJECTIVE: To investigate the injury patterns and risk factors of motorcycle crashes.DATA SOURCES: A computer-based online search was undertaken to identify English articles about motorcycle crashes published from January 1980 to December 2005 in Medline database and from January 1995 to December 2005 in EMCC database, the keywords were "motorcycle,crash, injury, traffic accident". Meanwhile, a manual search of relevant journals and monographs was performed for the articles and data published in Chinese.STUDY SELECTION: Based on the principles of reliability, advancement and efficiency, the data were primarily examined, and the original articles in this research field were selected to look up the full-texts. The repetitive studies and reviews were excluded.DATA EXTRACTION: Totally 87 articles were collected about the incidence, mechanism and protective methods of motorcycle crashes and motorcycle injuries, 36 of them were excluded, and finally 51 were enrolled.DATA SYNTHESIS: The most important variable affecting mortality in motorcycle crashes is head injury. Wearing a helmet should continue to be compulsory, as this single measure can help to reduce the mortality in motorcyclists. Thoracic and abdominal trauma as well as pelvic ring fractures associated with long bone injuries appears to be the secondary factors contributing to reduced survival. The injured motorcyclists were predominant young, novice inexperienced riders and male. A fatal outcome was more likely to be associated with a larger engine capacity motorcycle, collision with a heavy vehicle, head on collision, and collision at a non-junction road. Alcohol and excessive speed were common factors associated with motorcyclist crash involvement.CONCLUSION: Motorcycle crashes are an increasing public health problem in the present world. A thorough understanding of the injury patterns and risk factors in motorcyclists may improve the initial assessment and management of these patients and reduce the risk of inflicting further iatrogenic complications. Renewed and strengthened prevention efforts are warranted. A stricter enforcement of helmet laws would be effective to increase compliance with active protection devices. Stricter law enforcement also should be carried out to prevent alcohol-related accidents. It is hoped that these results will ultimately be used in concert with that from other researchers focusing on preventative devices to reduce the incidence of motorcycle crashes and still others examining specific therapies to address the type and nature of the motorcycle injury.

Human DAB2 interaction protein (DAB2IP) is a novel member of Ras GTPase-activating protein family. It interacts directly with disabled-2 protein (DAB2/DOC2) which suppresses growth of cancers derived from different tissues, including mammary, prostate and ovarian cancers. DAB2IP was identified as an immediate downstream effector mediated by DAB2/DOC2. DAB2IP and DAB2/DOC2 form a unique protein complex that has a negative regulatory effect on the Ras-mediated signal pathway. It is demonstrated that DAB2IP is a tumor suppressor gene inactivated by methylation in several cancers. This article reviews the structure and biological functions of DAB2IP gene as well as its potential roles in carcinogenesis and evolution.

Objective To explore the health of the thermal power plant worker in the noise,under the dust environment.Methods The oecupatiorml health inspection to the workers was carried.Results In 90 workers,41 were unusual,the detection rate is 45.6%.And the loss of hearing 11 people,the detection rate is 14.3%,other unusual 32 people,the detection rate is 35.6%.Conclusion We sheuld strengthen to the noise nuisance control,uses the effective protection of hearing measure,prevents occupational disease.

China faces opportunities and challenges as well when it participates in global environment and health governance. Major opportunities are as follows:(1) The convergence between global environment and health governance’s future trend and China’s environment and health strategies is a strongest incentive to push China to par-ticipate in global environment and health governance;(2) China can benefit from this participation in term of more access to international resources; ( 3 ) Global environmental and health issues are the areas that can best illustrate China’s international image as a responsible member; ( 4 ) Since global environmental and health governance is still young, early participation will give China a louder voice in its decision-making. The challenges that China faces are as follows:(1) Huge pressure from domestic environment and health challenges forces China to be primarily inward-looking and makes it very hard for the country to keep a high profile in global environment and health governance. China also faces the increasing international pressure. ( 2 ) The lack of global environment and health governance strategy prevents China from effectively participating in global environment and health governance. (3)“The Grand Health Outlook”hasn’t been fully established yet in China, leaving much room for improvement. (4) Intellectual sup-port is inadequate. (5) Some countries have too high expectations of China in terms of its contribution to global envi-ronmental and health governance. In order to effectively participate in this field, China should undertake coordinated planning on both the international and domestic scenes, and take some specific policies both at national and interna-tional level.

Objective To investigate the expressions of enhancer of zeste(EZH2) in carcinoma of esophagus and its potential significance. Methods The expression and distribution of EZH2 were determined on the esophageal squamous carcinoma,adenocarcinoma by using immunohistochemistry.We then detected EZH2 protein expression in the esophageal squamous carcinoma, paracarcinomatous and normal tissues by Western blotting.Results The immunohistochemical staining showed EZH2 protein was highly expressed in esophageal squamous carcinoma and adenocarcinoma tissues.The positive staining was observed in the nuclear region.Normal tissues and corresponding paracarcinomatous tissues were stained weakly.Western blotting analysis showed that the strongest positive signals were detected in the esophageal squamous carcinoma(P

Bone and soft tissue bleeding often results in substantial amounts of blood loss during the total knee arthroplasty(TKA). Multiple studies have reported that cumulative blood loss varies from 500 to 1500 mL in primary settings. Increased perioperative blood loss frequently requires allogeneic blood transfusions to improve the hematocrit and hemoglobin levels. However,allogeneic transfusion is associated with risks of immunosuppression,transfusion reactions,graft versus host disease,and transmission of infec-tions. To avoid these problems and reduce costs of transfusion,multiple intraoperative pharmacotherapeutic strategies have been developed. The various pharmacotherapeutic agents currently used include tranexamic acid,epsilon-aminocaproic acid,fibrin,thrombin,lavage with epinephrine,and norepinephrine. However, the relative efficacy and the cost-effectiveness of these agents may vary. Thus,the purpose of this study was to provide a brief overview of the relative efficacy of various intraoperative pharmacological methods cur-rently in use for decreasing blood loss following TKA and describe their potential complications associated with their application.

Objective:To evaluate the efficacy of imaging diagnisis of congenital pulmonary agenesis and hypoplasia in children.Methods:The 13 cases of congenital pulmonary agenesis and hypoplasia were veritfied by bronchcscopy and operation or pathology the characteristics of the X-ray,CT and bronchography were analysed.Results:the X-ray features included:(1)capacity decreased and density increased of diseased lung;(2)small hilar pulmonis;(3)mediastinum shifted to the affected side.Conclusion:Radiography is a good procedure in diagnosis of the most cases of congenital pulmonary agenesis and hypoplasia.

Mammalian target of rapamycin (mTOR) plays an important role in the regulation of cell proliferation,growth,energy metabolism and so on.Clinical research demonstrate that many tumors have its excessive expression, and the mTOR inhibitors rapamycin can resist the development of gastric cancer.Research of mTOR signaling pathway combined with its upstream and downstream has larger value for the early diagnosis,monitoring curative effect and prognosis.

High mobility group box-1 (HMGB1) is a nonhistone nuclear protein.Normally,as one component of the chromatin,HMGB1 regulate life activities such as genetic transcription,recombination and gene repair.HMGB1 can be realeased to the outside of the cell,which can be bound up with cells multiplication,differentiation,migration and the growth of nerve axon.Studies show that HMGB1 is correlated with tumor (s) occurrence,development,invasion and metastasis,such as lung cancer,colorectal cancer,pancreatic cancer and so on.The studies about the relativity between HMGB1 and gastric cancer play an important role in the diagnosis and treatment of gastric cancers.

Objective To evaluate the applicated value of color Doppler ultrasonography (CDUS) and CR molybdenum target in the diagnosis of breast nodules.Methods Comparative analysis of 87 patients with breast nodules diagnosed by CDUS and CR molybdenum target were contrasted with postoperative pathology.Results 47 cases of 78 patients with breast nodules were benign lesions.39 cases were correctly diagnosed by CR molybdenum target,41 cases were correctly diagnosed by CDUS,and 44 cases were correctly diagnosed by CR molybdenum target and CDUS.Contrasted with postoperative pathology,the accuracy rates of breast disease diagnosed were 82.5％,75.0％ and 95.0％ diagnosed by CR molybdenum target,CDUS,CR molybdenum target and CDUS.Conclusion There is no significant statistical difference between CR molybdenum target and CDUS in the diagnosis of benign breast nodules.The accuracy rate of breast disease diagnosed by CR molybdenum target and CDUS is better than that diagnosed by CR molybdenum target or CDUS only.The two co-diagnosis are benefit to raise the accuracy rate of breast nodules.