Objective To investigate the anti-inflammatory effects on the vessel wall of rosuvastatin chow diet were treated with vehicle or various doses of rosuvagtatin(1,5,or 20 ms/kg)by subcutaneous injection for 2 or 6 weeks prior to sacrifice.Endothelial adhesiveness for monocytcs was determined by functional binding assay.The expressions of vascular cell adhesion molecule-1 and monocyte chemotactic protein-1 in the vessel wall were detected by quantitative real-time polymerase chain reaction.Results Endothelial adhesiveness for monocytes was significantly attenuated after 2 or 6 weeks treatments with 5 or 20 mg/kg rosuvaatatin.Rosuvastatin also significantly reduced the expressions of vescular cell adhesion moIecule-1 and monocyte chemotactie protein-1 in the vessel wall Conclusion The anti-inflammatory effects of suvagtatin might be responsible for attenuating the pathogenesis of atherogenesis in apolipoprotein E-deficient mice.