2.Preventive Effects of Iptakalim on Brain Edema Caused by Acute Hypobaric Hypoxia in Rats.
Space Medicine & Medical Engineering 2006;0(04):-
Objective To investigate the preventive effect of iptakalim hydrochloride(Ipt) on brain edema in rats after exposure to simulated high altitude and the mechanisms involved.Method Adult Wistar rats were randomly divided into normoxic control group,simulated plateau acute hypoxia group simulated 8 000 m for 8 h and three Ipt taking groups which were pretreated with 2, 4 and 8 mg(kg?d) of Ipt respectively for 7d before exposure to hypoxia.Water content was determined by the wet-dry method;Na~+,K~+,Ca~(2+) and Mg~(2+) content in the cortex was detected with all atomic absorption spectrophotometer;inorganic phosphorus standardization was applied to decide the activities of Na~+/K~+-ATPase,Ca~(2+)-ATPase and Mg~(2+)-ATPase;Occludin and AQP4 gene expression were determined by RT-PCR.Result The water content was increased and the concentration of Na~+ and Ca~(2+),the activities of Na~+/K~+-ATPase,Ca~(2+)-ATPase and Mg~(2+)-ATPase and the gene expression of the Occludin and AQP4 were all down-regulated in acute hypoxia group compared with normoxic control group.And these changes could be significantly relieved by pretreatment with Ipt.Conclusion Ipt can prevent the occurrence of brain edema caused by acute hypobaric hypoxia possibly related to the effect on water content,electrolytes concentration,ATPase activity and gene expressions of aquaporin and tight junction proteins.
3.Analyze the Drug Elasticity of Demand of Urban Residents through ELES Model
China Pharmacy 2001;0(09):-
OBJECTIVE:To analyze drug elasticity of demand of urban residents with quantitation.METHODS:Expand linear expenditure system(ELES)model was used to analyze sectional data of different kinds of consumption expenditure and the disposable income of urban residents in2003and to calculate the value of marginal consumption tendency,the elasticity value of demand income and the demand price.RESULTS&CONCLUSIONS:The changes of drugs price have little influence on drugs demand,for urban residents,drugs consumption belongs to necessary for life.
5.Clinical experience of treatment of miscellaneous diseases by cupping at Shenque (CV 8).
Chinese Acupuncture & Moxibustion 2013;33(10):943-944
Acupuncture Points
;
Adult
;
Aged
;
Anorexia
;
therapy
;
Child
;
Constipation
;
therapy
;
Female
;
Humans
;
Inflammation
;
therapy
;
Male
;
Medicine, Chinese Traditional
;
methods
;
Pruritus
;
therapy
6.Clinical analysis of acute Avermectins poisoning.
Peng JI ; Hai-Bo ZHU ; Yong LIANG
Chinese Journal of Industrial Hygiene and Occupational Diseases 2009;27(7):437-437
Acute Disease
;
Adolescent
;
Adult
;
Aged
;
Child
;
Female
;
Follow-Up Studies
;
Humans
;
Ivermectin
;
analogs & derivatives
;
poisoning
;
Male
;
Middle Aged
;
Retrospective Studies
;
Young Adult
7.Study on the application of mast cells in the pathogenesis of allergic rhinitis.
Journal of Clinical Otorhinolaryngology Head and Neck Surgery 2018;32(2):157-160
The pathogenesis of allergic rhinitis(AR)is extremely complex.In recent years,a variety of allergens and other complexes have been developed to induce a series of signal transduction mechanisms by activating mast cells.Intracellular media release(mast cells,MCs)play an important role in the pathogenesis of AR.In this paper,we reviewed the progress of mast cells in the pathogenesis of allergic rhinitis in recent years in order to further understand its role in the pathogenesis of allergic rhinitis and provide new ideas on the therapeutic target for allergic rhinitis.
Allergens
;
Cell Count
;
Humans
;
Mast Cells
;
Rhinitis, Allergic
;
immunology
;
Signal Transduction
8.Progress in treatment of infantile spasms.
Chinese Journal of Pediatrics 2006;44(4):277-279
Humans
;
Infant
;
Spasms, Infantile
;
therapy
10.Relationship between refractive error and influencing factors in Children
Hai-Jun, SHI ; An-Li, HU ; Hong, ZHU
International Eye Science 2014;(8):1473-1475
AIM: To evaluate the relationship between axial length ( AL ) , corneal and lens refractive power, and the refractive error in children.
METHODS:Totally 44 children 88 eyes with refractive error who underwent retinoscopy with cycloplegia, to be measured spherical equivalent refractive error. Axial length was measured by a noncontact optical biometry ( ZEISS IOL-Master) , and corneal K and anterior chamber depth ( ACD) were also measured by the same machine. The refractive power of the lens was calculated by using the SRK formula. The patients were divided into 3 groups, myopia (SE<0), hyperopia (SE>+0. 50D) and emmetropia ( 0 to + 0. 50D ). Linear Correlation and Regression were used to evaluate the correlation among the optical parameters.
RESULTS:Totally 44 subjects, 88 eyes, average 9. 04±2.39 years, spherical equivalent (SE) -3. 50D to +8. 75D. Hyperopic AL was shorter than the other two groups ( P<0.05), same trend in lens power. No significant differences among the 3 groups in corneal K and ACD. There was a negative correlation between age and SE, SE and AL, SE and lens refractive power, and there was a positive correlation between age and AL, age and lens power.
CONCLUSION:As the children's growing up, SE trends to myopia, and AL becomes longer, and lens power is stronger.