1.CiteSpace-Based Visualization Analysis of Forensic Research in China from 2010 to 2019.
Hai-Biao ZHU ; Hong-Xia LIU ; Yu-Cong WANG ; Yi-Xun MA ; Dong ZHAO ; Xu WANG ; Tian-Tong YANG
Journal of Forensic Medicine 2022;38(4):478-485
OBJECTIVES:
To analyze the research status of forensic medicine in China from 2010 to 2019, obtain the development trend of forensic medicine and explore the hotspots and research frontiers.
METHODS:
The forensic medical academic papers published on China National Knowledge Infrastructure (CNKI) database from 2010 to 2019 were collected. CiteSpace 5.7.R1, an information visualization analysis software, was used to analyze publication organizations, authors, keywords, and other elements.
RESULTS:
The majority of the research institutions were universities, provincial and ministerial scientific research and forensic institutions. Forensic pathology was still an important branch of forensic medicine and a popular research direction. The "polymorphism" and "Y chromosome" had been the research hotspots in recent years. "Medical damage" and "standard" were the most novel studies.
CONCLUSIONS
In order to provide scientific basis and research direction for forensic research, this paper analyzes the cooperation network, research hotspots and research innovation in forensic research.
Forensic Medicine
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China
;
Forensic Pathology
;
Software
2.Haemoglobin E-beta Thalassaemia in Singapore.
Ee Shien TAN ; Cedric KOH ; Hai Yang LAW ; Guek Peng TAN ; Angeline Hwei Meeng LAI ; Ivy Swee Lian NG
Annals of the Academy of Medicine, Singapore 2014;43(6):331-333
Adolescent
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Adult
;
Child
;
Child, Preschool
;
Female
;
Hemoglobin E
;
analysis
;
Humans
;
Male
;
Middle Aged
;
Retrospective Studies
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Severity of Illness Index
;
Singapore
;
Young Adult
;
beta-Thalassemia
;
blood
;
therapy
4.Analysis of the changes of amide A in rabbit heart after death by FTIR spectroscopy.
Hai-Dong ZHANG ; Tian-Tong YANG ; Na ZHENG ; Ting-Yi SUN ; Liang LIU
Journal of Forensic Medicine 2011;27(5):321-323
OBJECTIVE:
To explore the relationship of changes of amide A in rabbit heart and the postmortem interval (PMI) by FTIR spectroscopy technique.
METHODS:
Thirty-two rabbits were sacrificed and the hearts were sampled at 20 degrees C within 48 h postmortem points. All samples were sliced and tested by FTIR spectroscopy technique. The images of amide A were created by FTIR spectroscopic imaging. The positive and negative area ratios of amide A were analyzed using imaging analysis system.
RESULTS:
The positive and negative area ratios declined regularly with the prolongation of death time in 48 h. There was a significant quadric relationship between the area ratios (y) of amide A (positive and negative area) and PMI(x). The regression equation was y = 0.001x2-0.038x + 0.747(R2 = 0.940).
CONCLUSION
The ratios of positive and negative area of amide A showed a strong correlation with PMI and could be used to estimate PMI.
Amides/metabolism*
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Animals
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Female
;
Forensic Pathology/methods*
;
Male
;
Myocardium/metabolism*
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Postmortem Changes
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Rabbits
;
Regression Analysis
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Spectroscopy, Fourier Transform Infrared
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Time Factors
5.Correlation between the changes of oxidation reduction potential values and postmortem interval of heart blood in rabbits after death.
Tian-tong YANG ; Yong-guang YU ; Jing BAI ; Hai-dong ZHANG ; Ting-yi SUN ; Mary G RIPPLE ; David R FOWLER ; Li LING
Journal of Forensic Medicine 2013;29(5):321-329
OBJECTIVE:
To investigate correlation between the changes of oxidation reduction potential (ORP) values of heart blood in rabbits after death and postmortem interval (PMI) at different temperatures.
METHODS:
Forty-eight rabbits were randomly divided into 6 groups and sacrificed by air embolism. Blood samples were taken from the right ventricle of each rabbit and stored at different temperatures of 10, 15, 20, 25, 30 and 35 degrees C, respectively. Every 4 hours from 0 h to 132 h postmortem, the ORP values of the blood samples were measured at different intervals by PB-21 electrochemical analyzer. The curvilinear regression equation was established by SPSS 17.0 software. The surface equation and 3D surface diagram were established by MATLAB 7.10.0 software.
RESULTS:
The ORP values at different temperatures of heart blood in rabbits were highly correlated with the PMI. The ORP values rised obviously when the temperature was high and rised slowly when the temperature was low. The surface equation and 3D surface diagram were obtained.
CONCLUSION
The surface equation and 3D surface diagram of ORP values and PMI may be used for PMI estimation at different temperatures.
Animals
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Blood
;
Female
;
Forensic Pathology/methods*
;
Heart
;
Male
;
Oxidation-Reduction
;
Oxygen/analysis*
;
Postmortem Changes
;
Rabbits
;
Regression Analysis
;
Temperature
;
Time Factors
6.Exploring Anti-inflammation Mechanism of Pien Tze Huang via Regulating of Microglia Polarization
Hai-yang SHU ; Dan-cai FAN ; Ning ZHAO ; Cheng LYU ; Ai-ping LYU ; Xiao-juan HE
Chinese Journal of Experimental Traditional Medical Formulae 2020;26(5):48-53
Objective::To investigate the anti-inflammation mechanism of Pien Tze Huang (PTH) via regulating microglia polarization. Method::The experiment was divided into five groups, Blank, M1[lipopolysaccharide (LPS) 100 μg·L-1+ interferon-
7.Metabolism of the synthetic cannabinoid PX-2 in human liver microsomes
Hai HEI ; Ying ZHANG ; Duo-qi XU ; Yan-yan WANG ; Shi-yang QIN ; Ji-fen WANG ; Wen-fang ZHANG
Acta Pharmaceutica Sinica 2020;55(6):1201-1208
This study was performed to determine the metabolic profile of a new illicit drug, PX-2, in human liver microsomes. Q Exactive™ HF Quadrupole-Orbitrap LC-MS (LC-QE-HF-Orbitrap-MS) was employed to determine the metabolic sites and pathways of phase Ⅰ and phase II metabolism. PX-2 was added to a microsomal incubation model to simulate human hepatic metabolism. The results showed that a total of 18 phase Ⅰ metabolites and 3 glucuronidated phase II metabolites were generated, with the main metabolic pathways of phase Ⅰ metabolism including amide hydrolysis, fluoropentyl oxidative defluorination, benzyl hydroxylation, and carbazole ring hydroxylation. Based on the type and sites of metabolism, phase Ⅰ metabolites M1.1 (amide hydrolysis), M4.1 (carbazole cyclic hydroxylation), and M3.1 (oxidative defluorinative hydroxylation) are proposed to be potential poisoning markers. The results of this study provide a basis for identification of related drugs and establishment of testing methods in biological samples.
8.Chinese guideline for the application of rectal cancer staging recognition systems based on artificial intelligence platforms (2021 edition).
Yuan GAO ; Yun LU ; Shuai LI ; Yong DAI ; Bo FENG ; Fang-Hai HAN ; Jia-Gang HAN ; Jing-Jing HE ; Xin-Xiang LI ; Guo-Le LIN ; Qian LIU ; Gui-Ying WANG ; Quan WANG ; Zhen-Ning WANG ; Zheng WANG ; Ai-Wen WU ; Bin WU ; Ying-Chi YANG ; Hong-Wei YAO ; Wei ZHANG ; Jian-Ping ZHOU ; Ai-Min HAO ; Zhong-Tao ZHANG
Chinese Medical Journal 2021;134(11):1261-1263