The authors analysed 92 patients who were operated with laminectomy and disectomy for herniated lumbar discs from August 1984 to July 1986 at the Depart. of neurosurgery, Korea University College of Medicine. The authors tried to grade the degeneration of nucleus pulposus pathologically in accordance with the severity of collagenosis and to correlate between these gradings with clinical and radiologic findings. The results were as follows, 1) Collagenosis seemed to be normal aging process of lumbar discs. 2) Duration of clinical symptoms, narrowing of the disc space and spur formation were correlated with the severity of collagenosis. 3) Sequestered discs seemed to promote the progression of collagenosis.
Aging ; Humans ; Korea ; Laminectomy ; Neurosurgery

PURPOSE: Following up the cases of cow's milk-sensitive enteropathy (CMSE), We observed the development of clinical tolerance with cow's milk and other foods. We investigated the clinical outcome of CMSE. METHODS: We reviewed the clinical records of patients who had been admitted and diagnosed as CMSE by responses to cow's milk challenge and elimination test and the findings of small intestinal biopsy at Department of Pediatrics, Taegu Catholic University Hospital from March 1992 to March 1997. All of them were being fed with protein hydrolysate before 6 months old, and tried cow's milk and other foods challenge test at following each two month. Twenty-one cases of them returned to be followed. The age at admission was 30.7+/-8.8 (18~47) days old and at survey was 43.4+/-23.7 (16~84) months old. RESULTS: 1) Although the body weight at birth of the patients was 25~75 percentile, all on admission was below 3 percentile. The body weight on interview was 25~75 percentile. 2) The development of clinical tolerance in cow's milk was observed at 16~24 months of age and the tolerance rate was 61% at 12 months of age, 90% at 16 months of age. The development of clinical tolerance in other foods was observed at 10~24 months of age and the tolerance rate was 33% at 12 months of age, 80% at 18 months of age. 3) Adverse reactions after challenge test with cow's milk were observed at 19 cases, manifestated as vomiting (31%), diarrhea (31%), irritability or lethargy (21%), skin rash (10%), and abdominal distention (5%). 4) Comparing serum IgE and milk RAST positive group on admission (5 cases) and negative group on admission (16 cases), there was no significant difference at the age of tolerance in cow's milk (p>0.05), the age of tolerance in other foods (p>0.05), allergy history in family, and the incidence of other allergic diseases. 5) The history of family allergy was observed in 3 cases (14%) in 21 patients and 3 cases (14%) showed rhinitis, urticaria or asthma through a follow-up interview. CONCLUSION: The development of clinical tolerance in cow's and other foods was sharply increased at 12 months of age and most of all tolerated within 24 months of age. CMSE is a temporary disorder of infancy.
Asthma ; Biopsy ; Body Weight ; Daegu ; Diarrhea ; Exanthema ; Follow-Up Studies* ; Humans ; Hypersensitivity ; Immunoglobulin E ; Incidence ; Infant ; Lethargy ; Milk ; Parturition ; Pediatrics ; Rhinitis ; Urticaria ; Vomiting