A compartment model with separate pharmacokinetic estimates for children and adults was found best to describe the disposition of artemisinin after oral administration. The popular estimates for artemisinin half life and clearance and distribution volume were found for both age groups. The concentration was estimated decrease from day 1 to day 5, a value found to be similar for children and adults. Clinical efficacy, in terms of parasite clearance and fever subsidence times, was comparable between children and adults no difference
Malaria ; artesunate ; therapeutics ; child ; adult ; diagnosis

The study was conducted in 2002 for analysis by non-linear regression of compartmental pharmacokinetic model. The results: the plasma-concentration of piperaquine at day 1 and day 3 after CV8 administration were determined. At first stage, only the basic parameters derived from non-compartmental methods were presented and another parameters, models is expected to be presented in later stages. The plasma-concentration of piperaquine of all volunteers were determined with Cmax on day 1 was 1015 nM/L, on day 2 was 1050 nM/L, T1/2 was 30-57 days and Tmax of piperaquine was 3-5 hours after using
Malaria ; Antimalarials ; Pharmacokinetics ; Therapeutics ; drugs

The Micheal Ashton's modified method was used to determinate artesunate (AS) concentrations in tablets and injection forms in order to improve the skillfulness of laboratory staff of National Institute of Malariology - Parasitology - Entomology. Average contents of artesunate of the tablets and injection form of the samples collected in 2001 and 2002 which met the stipulated criteria of Ministry of Health. Tablet content in 2001 was 48.09mg/tablet and in 2002 was 48.40mg/tablet. Injection content in 2001 was 60.50mg/vial and 56.09mg/vial in 2003
artemisinins ; Tablets ; Injections ; Chromatography, High Pressure Liquid

Antimalarial drug samples were collected from different parts of the country for quality investigation in 2004. A total of 129 samples of different batches were collected at three rounds and cross-checked at local, central level and abroad. At the round one, three out of 49 collected samples were found substandard. One of 40 samples of the second round was determined counterfeit (2.5%). The re-analysis of 51 samples at NIDQC revealed two from the first round were substandard and one from the second round was counterfeit
Malaria ; Therapeutics ; Pharmaceutical Preparations

Background: Monitoring antimalarial drug quality should be conducted regularly in locals to enhance the effect of treatment for malaria \r\n', u'Objective: to study and analyze antimalarial drug quality\r\n', u'Subjects and methods: The study was carried out in 2007 for 5 provinces supported by the Global Fund: Ha Giang, Dien Bien, Thanh Hoa, Quang Tri and Gia Lai. Material were malaria drugs: artesunat, chloroquin, quinine, mefloquin, fansidar\u2026etc\r\n', u'Results and conclusion: The strict supervision on the anti-malarial drug quality by the National Malaria Control Program was very good and no substandard antimalarial drugs were detected. Evaluation of antimalarial drug quality and control was made for finding out the counterfeit drugs through sentinel sites in both private and public sectors. A total of 268 samples were collected, of which 13 samples were found substandard drugs (8 samples collected in private and 5 samples in public sectors). No counterfeit drugs were found. \r\n', u'
Antimalarial drug ; quality ; monitoring