2.Relationship of oncogene survivin、c-erbB-2 expression in breast cancer and its prognostic significance
Jie MAO ; Jian HAI ; Hengping SHU
China Oncology 2001;0(05):-
Purpose:To investigate the expression of oncogene survivin,c-erbB-2 in breast cancer and its prognostic significance.Methods:Detect the expression of survivin,c-erbB-2 in 80 case breast cancer tissues by immunohistochemistry S-P method,analyze its correlation with axillary lymph node metastasis and 5-year disease free survival(DFS).Results:Survivin gene positive expression rate was 68.75%(55/80),c-erbB-2 gene positive expression rate was 36.25%(29/80) in breast cancer tissues,all have positive correlation with the axillary lymph nodes metastasis but negative to 5 years DFS(P0.05);survivin and c-erbB-2 genes expression have positive correlation(P
3.Percutaneous fixation for the treatment of un-displaced scaphoid fractures with herbert cannulated screws through volar approach.
China Journal of Orthopaedics and Traumatology 2014;27(3):187-190
OBJECTIVETo summarize the experience of percutaneous fixation of scaphoid fractures with Herbert screws through volar approach, and provide a reliable and efficient treatment method for scaphoid fractures.
METHODSFrom April 2008 to September 2012,15 patients with scaphoid fractures were treated by percutaneous fixation with Herbert cannulated screws through volar approach including 14 males and 1 female with an average age of 35 years ranging from 25 to 45 years old. Among them, 10 cases were on left side and 5 cases were on right side. Durations from injury to operation ranged from 3 to 10 days with an average of 5 days. All these cases were identified as B2 type according to the Herbert classification based on X-ray and CT scan. In order to assess the function of wrist, all patients were calculated according to Krimmer's score postoperatively.
RESULTSThe follow-up period were from 5 to 18 months with an average of 10 months. At 3 months after operation,X-ray was re-checked every month. All the patients achieved bone union with a mean time of 10 weeks (ranged from 7 to 14 weeks) postoperatively. According to Krimmer's score, 14 cases gained 100 scores as perfect and one case got 90 scores as good. The small volar incision of all patients were union at the first period. No operation complications such as infection and nonunion occurred.
CONCLUSIONPercutaneous fixation with Herbert cannulated screws through volar approach is a reliable and efficient treatment method for scaphoid fractures with small invasion, high bone union rate, and fewer complications.
Adult ; Bone Screws ; utilization ; Female ; Fracture Fixation, Internal ; instrumentation ; methods ; Fractures, Bone ; physiopathology ; surgery ; Fractures, Ununited ; surgery ; Humans ; Male ; Middle Aged ; Range of Motion, Articular ; Scaphoid Bone ; injuries ; physiopathology ; surgery ; Treatment Outcome ; Wrist Injuries ; physiopathology ; surgery ; Wrist Joint ; physiopathology ; surgery
4. Charge storage stability of electret film made of polypropylene/porous polytetrafiuoroethylene/polypropylene composite
Academic Journal of Second Military Medical University 2010;30(5):473-476
Objective: To study charge storage stability of electret film made of polypropylene (PP)/porous polytetrafiuoroethylene(PTFE)/polypropylene composite. Methods: The PP/porous PTFE/PP composite electret film was prepared with porous PTFE, polyethylene(PE) and PP by heat melting technique. The charge storage stability of the electret film and transportation were evaluated by using the methods of isothermal surface potential attenuation and open-circuit thermally stimulated discharge (TSD) current spectra. Results: (1) The charge storage stability of PP/porous PTFE/PP composite electret was superior to that of PP electret made under ordinary temperature, because the space charge of PP/porous PTFE/PP electret was transferred from deep trap to flat trap during the heat melting process. (2) Satisfactory charge storage stability was observed in PP/porous PTFE/PP electret when under the condition of high humidity. Conclusion: PP/porous PTFE/PP electret film has satisfactory charge storage stability and can be used as a novel enhancer in transdermal delivery of drugs.
6.Application of Scaffolds in Construction of Random Peptide Libraries and Targeted Molecules Selection
Hong-Guang GUO ; Hai-Jiang WU ; Can-Quan MAO ;
China Biotechnology 2006;0(09):-
Nature is abundant in protein scaffolds.By selecting suitable protein scaffold,display and screening methods,the rational and constrained random peptide library(RPL)can be constructed.Compared with the non-constrained RPL,it offered more opportunities for obtaining novel protein structures and more higher affinity ligands against the target molecules.At present,the protein scaffold constrained RPLs have been shown great potential in applications such as target selection,basic research,clinical diagnosis,medical therapy and so on.It is systematically introduced the structure bases,classification and construction of constrained RPL based on scaffolds,as well the recent great advances of application in selection against target molecules with S-S constrained scaffolds,antibodies,Zinc finger protein,Z domain,FN3 domain as important examples.
7.Expression of surviving and its correlation with thymidine kinase and axillary lymph node metastasis in breast cancer
Qing GAO ; Jianping WU ; Yongrong MAO ; Hai LAN
Cancer Research and Clinic 2000;0(01):-
Objective To investigate the expression of survivin and its correlation with tumor thymidine kinase and axillary lymph node metastasis in breast cancer. Methods Expression of survivin and cytosolic thymidine kinase(TK) in 60 cases of breast cancer(28 cases with axillary lymphonode metastasis) were measured by immunohistochemistry. Results There was expression of survivin in breast cancer; labeling index(LI) of TK in breast cancer cells with positive expression of survivin was significantly higher than that with negative expression of survivin;the positive percent of survivin expression in breast cancer with axillary lymph node metastasis was higher than that without axillary lymph node metastasis. Conclusions The expression of survivin in breast cancer is related to TK and axillary lymph node metastasis.
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