No abstract available.
Animals ; Mice* ; Plants, Medicinal* ; Sarcoma 180* ; Sarcoma*

No abstract available.
Animals ; Linoleic Acid* ; Mice* ; Sarcoma 180* ; Sarcoma*

This 24 yrs. old male pt. visited our hosptial on september 1971, with complaints of visual disturbance, ocular pain in Lt. eye. Behcet's disease is usually Characterized by the triad of Hypopyon, uveitis, aphthous ulcer of the mouth and genitalia. A brief review of literatures has been descrived.
Genitalia ; Humans ; Male ; Mouth ; Stomatitis, Aphthous ; Uveitis

With the advent of modern surgical technique, the liberal use of whole blood transfusions has became widespread and so a variety of untoward reactions have been recognized. The complication of blood transfusions have been studied intensively during past 10 years, 1965~1974, in the Ewha Womans University Hospital. It has performed 3,589 cases of blood transfusions of at least 500cc during operation out of 10, 730 cases operation experiences. 184 cases among them were given massive blood transfusions of at least 2,000cc within about 3 hours period at operating room. The overall mortality was 9,8% and increased with the amount of blood given, the age of patient, complicating medical conditions, anatomical site of trauma, shock and operation time. When shock was prevented or quickly corrected, the mortality was decreased. However, when prolonged shock occurred in patients with preexisting or associated disease, the mortality was increased. The complications of transfusion were generally urtiearia (61%), high fever (15g) shock(12%), and wound infections (2%). The causes of death following transfusion may depend upon the complications of transfusion.
Blood Transfusion* ; Cause of Death ; Female ; Fever ; Humans ; Mortality ; Operating Rooms ; Shock ; Wound Infection

PURPOSE: Peripheral neuropathy is the most common chronic complication of insulin- dependent diabetes mellitus, which is one of the most frequent endocrine metabolic disorders in children. However, there are very few long-term follow-up studies on the condition in publication and none in Korean literature. In order to find out the correlation between the severity of peripheral neuropathy and glycosylated hemoglobin level, an indicator of diabetes control, a follow-up study was conducted on cases of insulin- dependent diabetes mellitus. METHODS: The study was conducted on 37 patients with insulin-dependent diabetes mellitus (12 males, 25 females, aged 7-21 years) who were diagnosed and were being treated in general hospitals in the Taegu-Kyungpook area from 1994 to 1998. They were also subject to nerve conduction velocity test at least two times with an interval of one or more years. Nerve conduction velocity was measured by using type MEM-3102 apparatus of Nihon Kohden (on motor and sensory component of left ulnar nerve and median nerve, motor component of left and right peroneal, posterior tibial nerve, sensory component of left and right sural nerve) and medical history was taken, neurological examination was done and glycosylated hemoglobin levels were measured with each test. RESULTS: The total number of nerve conduction velocity tests was 89 and the results were divided into 5 groups [normal : 14 cases (15.7%); borderline: 35 cases (39.3%); mononeuropathy : 2 cases (2.2%); mild polyneuropathy : 22 cases (24.7%); severe polyneuropathy : 16 cases (18.0%)] by the number and distributions of nerves that were found abnormal. Ten of the 26 cases, belonging to the normal or borderline group in the first test, showed signs of peripheral neuropathy in later tests, and of the 11 cases with peripheral neuropathy in the first test, none improved to be included in the normal or borderline group in the follow-up study. The mean glycosylated hemoglobin level was 9.2+/-2.5% in normal group, 11.9+/-3.2% in borderline group, 13.0+/-0.3% in mononeuropathy group, 12.0+/-3.7% in mild polyneuropathy group and 14.8+/-4.0% in severe polyneuropathy group, and glycosylated hemoglobin level rose with the severity of the neuropathy (r=0.372, p< 0.01). In the 9 cases that had shown improvement of peripheral neuropathy, glycosylated hemoglobin levels decreased significantly by an average of 3.5+/-1.3% with each level of improvement (t-test, p<0.05), but in 20 cases with deteriorating nerve conduction velocity, there was no significant correlation with increase in glycosylated hemoglobin levels. CONCLUSION: Peripheral neuropathy complicating insulin-dependent diabetes mellitus can occur during diabetes treatment and does not improve easily once it occurs. In this study, the glycosylated hemoglobin level was shown to have a high degree of correlation with the occurrence and progression of neuropathy, which means that control of hyperglycemia is difficult and also that stricter control of blood glucose during early stages of diabetes is necessary to prevent neuropathy. Follow-up studies with bigger samples and longer time will be needed for a more detailed look.
Blood Glucose ; Child ; Diabetes Mellitus ; Diabetes Mellitus, Type 1* ; Female ; Follow-Up Studies* ; Hemoglobin A, Glycosylated ; Hospitals, General ; Humans ; Hyperglycemia ; Male ; Median Nerve ; Mononeuropathies ; Neural Conduction ; Neurologic Examination ; Peripheral Nervous System Diseases* ; Polyneuropathies ; Publications ; Tibial Nerve ; Ulnar Nerve

PURPOSE: The purpose of this study was to compare the nursing activities delineated by interview of nurses with those on nursing notes. METHOD: The participants of interview were 18 nurses working in medical and surgical units of a large hospital in Seoul. Each nurse was asked to choose one patient who demand most nursing care among her patients. The nurse was then interviewed to describe what her nursing activities for the patient was that day. The audio-taped interview was transcribed and the content was analyzed by researchers. Nursing notes of each nurses' patients were copied and the content analyzed by researchers. Finally, themes from the interview data and those from nursing notes were compared. RESULT: Activities related to emotional or psychological nursing, education for patient and families, and problem solving related to treatment or nursing procedure were most often omitted in nursing notes. Most of the documentation in nursing notes were related to physical condition of patients or physician's orders. Nurses described that they will do better recording if they were given less patient care responsibility, had better nursing knowledge, had better recording system, and received more training on nursing record. CONCLUSION: Nursing notes did not reflect nursing activities properly. Few independent nursing roles were documented in the nursing notes. Development of nursing education program and nursing record system is needed for improvement of nursing record.

Incidence of nontuberculous mycobacterium (NTM) pulmonary disease is increasing with the wider recognition and development of diagnostic technology. Mycobacterium kansasii is the second most common pathogen of NTM pulmonary disease in human immunodeficiency virus (HIV)-infected patients. However in Korea, the incidence of M. kansasii pulmonary disease is relatively low, and there has been no report of M. kansasii pulmonary disease with bronchial involvement in HIV patients, to the best of our knowledge. We report a case of M. kansasii pulmonary disease presenting with endobronchial lesions in an HIV-infected patient complaining of chronic cough with bilateral enlargements of hilar lymph nodes on chest X-ray.
Bronchial Diseases ; Cough ; HIV ; Humans ; Incidence ; Korea ; Lung Diseases* ; Lymph Nodes ; Mycobacterium kansasii* ; Mycobacterium* ; Nontuberculous Mycobacteria ; Thorax

Purpose: This study aimed to investigate the potential role of copine-1 (CPNE1), a calcium-dependent membrane-binding protein encoded by the CPNE1 gene, in colorectal cancer (CRC). Despite previous research on the involvement of copine family members in various solid tumors, the specific role of CPNE1 in CRC remains poorly understood. Methods: We conducted clinicopathological analysis and functional studies to explore the impact of CPNE1 in human CRC.We examined the expression levels of CPNE1 in CRC patients and correlated it with invasive depth, lymph node metastasis, distant metastasis, lymphatic invasion, and TNM stage. Additionally, we performed experiments to assess the functional consequences of CPNE1 knockdown in CRC cells, including proliferation, colony formation, migration, invasion, and the expression of key regulators involved in the cell cycle and epithelial-mesenchymal transition (EMT). Furthermore, we evaluated the effects of CPNE1 knockdown on tumor growth using a xenograft mouse model. Results: High expression of CPNE1 was significantly associated with advanced tumor features in CRC patients. CPNE1 knockdown in CRC cells led to impaired abilities in proliferation, colony formation, migration, and invasion. Furthermore, CPNE1 silencing resulted in the suppression of protein expression related to the cell cycle and EMT. In the xenograft mouse model, CPNE1 knockdown inhibited tumor growth. Conclusion CPNE1 plays a crucial role in promoting tumorigenesis and metastasis in human CRC. By regulating the cell cycle and EMT, CPNE1 influences critical cellular processes at the membrane-cytoplasm interface. These results provide valuable insights into the potential development of novel therapeutic strategies for CRC targeting CPNE1.

BACKGROUND: The number of patients diagnosed with hereditary hemolytic anemia (HHA) has increased since the advent of novel diagnostic techniques that accurately identify this disorder. Here, we report data from a survey on the prevalence and characteristics of patients diagnosed with HHA in Korea from 2007 to 2011. METHODS: Information on patients diagnosed with HHA in Korea and their clinical and laboratory results were collected using a survey questionnaire. Globin gene and red blood cell (RBC) enzyme analyses were performed. In addition, we analyzed data collected by pediatricians. RESULTS: In total, 195 cases of HHA were identified. Etiologies identified for HHA were RBC membranopathies, hemoglobinopathies, and RBC enzymopathies, which accounted for 127 (64%), 39 (19.9%), and 26 (13.3%) cases, respectively. Of the 39 patients with hemoglobinopathies, 26 were confirmed by globin gene analysis, including 20 patients with beta-thalassemia minor, 5 patients with alpha-thalassemia minor, and 1 patient with unstable hemoglobin disease. CONCLUSION: The number of patients diagnosed with hemoglobinopathies and RBC enzymopathies has increased considerably since the previous survey on HHA in Korea, dated from 1997 to 2006. This is likely the result of improved diagnostic techniques. Nevertheless, there is still a need for more sensitive diagnostic tests utilizing flow cytometry and for better standardization of test results to improve the accuracy of diagnosis of RBC membranopathies in Korea. Additionally, more accurate assays for the identification of RBC enzymopathies are warranted.
alpha-Thalassemia ; Anemia, Hemolytic, Congenital ; beta-Thalassemia ; Diagnostic Tests, Routine ; Erythrocytes ; Flow Cytometry ; Globins ; Hematology ; Hemoglobinopathies ; Hemoglobins ; Humans ; Korea ; Prevalence ; Spherocytosis, Hereditary ; Thalassemia ; Surveys and Questionnaires

BACKGROUND/AIMS: The role of induction chemotherapy (IC) for eyeball preservation has not been established in head and neck squamous cell carcinoma (HNSCC) of the paranasal sinus and nasal cavity (PNSNC). Periorbital involvement frequently leads to eyeball exenteration with a margin of safety. We evaluated the treatment outcomes, including survival and eyeball preservation, of patients who received IC for HNSCC of the PNSNC. METHODS: We reviewed 21 patients diagnosed with HNSCC of the PNSNC who were treated with IC. We analyzed response, eyeball preservation rate, and overall survival. RESULTS: Tumors were located in the paranasal sinus (n = 14) or nasal cavity (n = 7). Most patients had stage T4a (n = 10) or T4b (n = 7) disease. More than half of the patients received a chemotherapy regimen of docetaxel, fluorouracil, and cisplatin (n = 11). Thirteen patients (61.9%) achieved a partial response after IC and 15 patients (71.4%) achieved T down-staging. Among 17 patients with stage T4 disease, which confers a high risk of orbital exenteration, 14 (82.4%) achieved preservation of the involved eye. The 3-year overall survival (OS) rate of patients who achieved a partial response to IC was 84.6%. The 3-year OS rate of patients with stable disease or disease progression after IC was 25.0% (p = 0.038). CONCLUSIONS: IC could be considered for down-staging patients with advanced T-stage disease. It could also be a reasonable option for eyeball preservation in locally advanced HNSCC of the PNSNC.
Carcinoma, Squamous Cell* ; Cisplatin ; Disease Progression ; Drug Therapy ; Fluorouracil ; Head and Neck Neoplasms ; Head* ; Humans ; Induction Chemotherapy* ; Nasal Cavity* ; Neck* ; Orbit ; Orbit Evisceration ; Organ Preservation* ; Paranasal Sinuses