2.Immunogenicity, reactogenicity and safety of a diphtheria-tetanus-acellular pertussis-inactivated polio and Haemophilus influenzae type b vaccine in a placebo-controlled rotavirus vaccine study.
Kong Boo PHUA ; Seng Hock QUAK ; Fong Seng LIM ; Paul GOH ; Yee Leong TEOH ; Sanjoy Kumar DATTA ; Htay Htay HAN ; Hans Ludwig BOCK
Annals of the Academy of Medicine, Singapore 2008;37(7):546-553
<b>INTRODUCTIONb>In recent years, acellular pertussis combination vaccines have facilitated compliance with and coverage of the national immunisation programme in Singapore. This phase-II study (Rota-007) evaluated the immunogenicity, reactogenicity and safety of a DTPa-IPV/Hib combined vaccine when co-administered with a rotavirus vaccine.
<b>MATERIALS AND METHODSb>A total of 2464 children aged 3 months were vaccinated with DTPa-IPV/Hib together with a randomised 1:3 ratio of either placebo (n=653) or 1 of 3 different formulations of a rotavirus vaccine. Blood samples were collected for immunogenicity analysis 1 month after the third DTPa-IPV/Hib vaccine dose in a subset of subjects (n = 640). Local and general reactogenicity and unsolicited adverse events were recorded during the follow-up after each vaccination.
<b>RESULTSb>Serological analysis showed >95% response for all antigens in the co-administered DTPa-IPV/Hib vaccine, with no difference between the rotavirus vaccine and placebo groups. No differences in adverse events and reactogenicity were reported in the rotavirus vaccine and placebo groups. Only 0.2% of the subjects reported Grade 3 adverse events. Three subjects (from the vaccine groups) died during the study, which were assessed by the investigators as unrelated to vaccination. No deaths were reported in the placebo group.
<b>CONCLUSIONb>The combined DTPa- IPV/Hib vaccine is safe, well tolerated and highly immunogenic when given alone or coadministered with the rotavirus vaccine for infants in Singapore.
Child ; Child Welfare ; Child, Preschool ; Double-Blind Method ; Female ; Haemophilus Infections ; immunology ; prevention & control ; Haemophilus influenzae type b ; isolation & purification ; Humans ; Infant ; Infant, Newborn ; Male ; Patient Compliance ; Poliomyelitis ; prevention & control ; Rotavirus Vaccines ; Singapore ; Vaccines, Combined ; Vaccines, Conjugate ; adverse effects ; immunology
3.Repeated Serum Alkaline Phosphatase Measurements in the Treatment of Childhood Acute Bone and Joint Infections with High Doses of Antibiotics.
Markus PAAKKONEN ; Markku J T KALLIO ; Pentti E KALLIO ; Heikki PELTOLA
Annals of Laboratory Medicine 2013;33(5):375-378
No abstract available.
Acute Disease
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Adolescent
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Alkaline Phosphatase/*blood
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Anti-Bacterial Agents/*therapeutic use
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Arthritis, Infectious/*drug therapy/*enzymology/microbiology
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*Bacterial Infections/drug therapy/enzymology/microbiology
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Child
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Child, Preschool
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Haemophilus influenzae type b/isolation & purification
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Humans
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Infant
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Osteomyelitis/*drug therapy/*enzymology/microbiology
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Staphylococcus aureus/isolation & purification
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Streptococcus pneumoniae/isolation & purification
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Streptococcus pyogenes/isolation & purification