1.Clinico-pathological Study on Hepatitis B virus-Associated Nephropathy.
Korean Journal of Pathology 1992;26(3):215-228
To clarify the characteristics of HBV-associated renal lesions, renal biopsies obtained from 22 HBsAg seropositive patients(M:F=32:1) were studied. Other than two(age 4 and 12), all were adults(17-77 y.o.). Twelve of the patients had nephrotic syndrome(NS), 5 NS and hematuria(H), 10 proteinuria and H, one gross H, one microscopic H, and 4 normal urinalysis at the time of biopsy. Light microscopy showed minimal change lesion(MCL) in 9 cases, mesangial proliferative glomerulonephritis(MSPGN) in 6, MPGN type I in 7, MPGN type III in 6, and mebranous nephropathy(MGN) in 5 cases. There were variable immunofluorescent(IF) findings of 25 cases studied; IF staining were predominant with IgG in 10 cases, with IgA in 5 and with IgM in 2 cases. Complements tended to be more strong for C1 &/or C4 than C3. In electron microscopic(EM) studies of MCL group, rare mesangial deposits were noted(3/5). In MSPGN, aside from mesangial deposits, there were occasional subendothelia(2/4) or subepithelial(1/4) deposits. In MPGN type I, in addition to the usual EM features of MPGN, some subepithelial deposits were also observed in 5 cases. In MGN, 3 out of 4 showed subendothelial deposits. Among 7 cases stained for HBsAg all were negative with IF and 2 were positive with PAP method. It is concluded that clinico-pathological findings of HBV-associated nephropathy are variable and partly show lupus-like features, different from primary glomerulopathy.
Adult
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Male
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Female
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Humans
;
Biopsy
2.Characterization of Principal Component Cell of DMBA induced Rat Malignant Fibrous Histiocytoma With Cell Culture and Cloning.
Myeng Sun PARK ; Hae Jin JEONG ; Man Ha HUH
Korean Journal of Pathology 1997;31(6):574-585
This experiment was performed to elucidate the cytologic origin of chemically induced MFH in Wistar rats. The tumor was produced by injections of DMBA(9,10-dimethyl-1,2-benzanthracene). With the produced MFH, cell culture and cloning were performed, followed by establishment of a cell strain, which was investigated by immunohistochemical and electron microscopic studies. The results were as follows. A) By immunohistochemistry of the tumor tissue, fibroblastic cells were positive for MEP-1(specific antibody for fibroblastlike cell of MFH, Takeya, 1993) and Anti-hPH(beta)(Anti-prolyl 4-hydroxylase beta), but negative for TRPM-3 and F4/80. Histiocytelike cells were positive for TRPM-3 and F4/80, but negative for MEP-1 and Anti-hPH(beta). In immunoelectron microscopy, normal spleen macrophage showed linear reactivity in cell membrane for TRPM-3, whereas histiocytelike cells of the tumor disclosed negative reaction. B) At 5 weeks of the primary tumor cell culture, the cells exhibited typical storiform pattern of MFH. C) The established cell strain revealed immunoreactivity for MEP-1 and Anti-hPH(beta), but negative for TRPM-3. The cloned tumor cells showed morphologic characteristics of undifferentiated fibroblastic cell. Latex particle (0.80 micrometer size) phagocytosis was negative in the cloned cell strain. The results of the current study support the concept that principal component cells of MFH is of fibroblastic cell origin.
9,10-Dimethyl-1,2-benzanthracene*
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Animals
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Cell Culture Techniques*
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Cell Membrane
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Clone Cells*
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Cloning, Organism*
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Fibroblasts
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Histiocytoma, Malignant Fibrous*
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Immunohistochemistry
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Macrophages
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Microscopy, Immunoelectron
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Microspheres
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Phagocytosis
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Rats*
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Rats, Wistar
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Spleen
3.The Clinical Observations in Childhood Asthma.
Bae Young KIM ; Hyun Soo PARK ; Hae Sun YOON
Journal of the Korean Pediatric Society 1986;29(8):68-75
No abstract available.
Asthma*
5.A Case of Agnogenic Myeloid Metaplasia.
Min Sook UM ; Jo Sam KOO ; Jae Sun PARK ; Sook Ja PARK ; Hae Kyung JANG
Journal of the Korean Pediatric Society 1988;31(11):1486-1493
No abstract available.
Primary Myelofibrosis*
6.Clinical Studies on the Emergency Management for 22 Cases of Heat Disorder .
Sung Tae PARK ; Sun Woong OH ; Hak Shim YOO
Korean Journal of Anesthesiology 1971;4(1):1-7
Heat disorders are not uncommon in the military society due to supposedly hard training to overcome the environmental conditions. Twenty-two soldiers with heat disorders were admitted to Chin Hae Naval Hospital June 1969 through July 1970. Hoping that our clinical studies on them contribute to a renewed understanding, the results are reported in summary as follows: 1) Heat disorders occurred with an overall incidence of 3.1 per cent during running in early summer. 2) Of the twenty-two patients, eight (37 per cent) had heat cramps, six (27 per cent) heat exhaustion, five(23 per cent) heat stroke, and three(13 per cent) had undetermined disorder. 3) Ten patients(45 per cent) were comatous, and this occurred most frequently(80 per cent) among those with heat stroke. 4) All patients were grouped into four according to their physical status on admission. Those with heat exhaustion mostly belonged to group I (good) or group II (fair). Those with heat stroke and heat cramps eomprised most of group III (poor) and group IV (grave). 5) Group I and II patients recovered within 12 hours; group III, within 12~24 hours; and group IV, required more than 24 hours of care. 6) One patient with heat stroke, graded V, expired with sudden hypothermia 15 hours following admission. Overall mortality of heat disorders was 4.5 per cent, and that of heat stroke 20 per cent. 7) The rest recovered uneventfully within 19 hours of average.
Chin
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Emergencies*
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Heat Exhaustion
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Heat Stress Disorders
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Heat Stroke
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Hope
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Hot Temperature*
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Humans
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Hypothermia
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Incidence
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Military Personnel
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Mortality
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Running
7.A case of the ipsilateral ovarian pregnancy following salpingectomy.
Hae Young KIM ; Jin LEE ; Eui Chang WANG ; Ae Jin SONG ; Young Sun PARK
Korean Journal of Obstetrics and Gynecology 1993;36(2):268-273
No abstract available.
Female
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Pregnancy
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Pregnancy, Ectopic*
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Salpingectomy*
8.Clinical features of bee venom anaphylaxis.
Sung Gyun AHN ; Sun Sin KIM ; Hee Yeon KIM ; Dong Ho NAHM ; Hae Sim PARK
Journal of Asthma, Allergy and Clinical Immunology 1999;19(3):492-497
Background and OBJECTIVE: There has been a few case reports of anaphylaxis due to honeybee in Korea. In order to observe the clinical feature of bee sting anaphylaxis. Moderials and methods: Six patients living in Kyunggi province area were referred under history of anaphylaxis after the bee sting. Atopy was defined by skin prick test result to common inhalant allergen. Serum specific IgE antibody to each bee antigen was detected by radioimmunoassay to identify the causative bee. RESULTS: All six cases were female. Three had atopy and four had combined allergic diseases such as allergic rhinitis, asthma, and urticaria. The etiologic bees consisted of yellow jacket (6 cases), paper wasp (4 cases), yellow hornet (3 cases), white faced hornet (1 case) and honey bee (1 case). Four cases had experienced anaphylaxis after ant bite and they showed positive result on specific IgE to imported fire ant. Specific immunotherapy against causative bee venom was begun using bee venom extracts from Bayer (USA) based upon results of specific IgE anti-body to bee venom. CONCLUSION: The yellow jacket is the most common cause of bee venom anaphylaxis in this area. Further studies will be needed to evaluate possible cross-reactivity between bee and ant venom.
Anaphylaxis*
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Ant Venoms
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Ants
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Asthma
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Bee Venoms*
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Bees*
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Bites and Stings
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Female
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Fires
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Gyeonggi-do
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Honey
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Humans
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Immunoglobulin E
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Immunotherapy
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Korea
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Radioimmunoassay
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Rhinitis
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Skin
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Urticaria
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Wasps
9.Inhibition of Interleukin-1 Signal by Annexin-1 in Phorbol Myristate Acetate Stimulated Lymphocytes.
Hae Jin RHEE ; Kun Koo PARK ; Doe Sun NA ; Ha Won KIM
Korean Journal of Immunology 1999;21(2):147-152
Annexin-1 (ANX1) is a 37 kDa protein that is induced and secreted by glucocorticosteroid hormone. The secreted ANX1 has been believed to exert its function by binding to its putative rnembrane receptor. In this report we demonstrate that ANXl receptor (ANX1R) signal blocks the interleukin-1B (IL-1B) receptor signal pathway in human peripheral blood mononuclear cells (PBMCs). When PBMCs were treated with both IL-1B (100 ng/ml) and PMA (10 ng/ml) in the absence or presence of dexamethasone for 5 days, dexamethasone (100 nM) suppressed lymphocyte proliferation to 24% of the control. However addition of anti-ANX1 polyclonal antibody of 1:200 and 1:1,000 dilution to this system induced recovery of proliferation to 80% and 40%, respectively, when compared to the control. In the mixed lymphocyte reaction, dexamethasone suppressed lymphocyte proliferation to 9% of that of control when stimulated with IL-1B (100 ng/ml) and phorbol myristate acetate (10 ng/ml). Addition of anti-ANX1 polyclonal antibody (1:1,000) to this system also recovered the proliferation to 20% of that of the control system. In the ANX1 receptor induction experiment using flow cytometry, ANX1 receptor expression on lymphocytes, CD4+ T cells, CD8+ T cells and monocytes increased depending on the externally added IL-1B ranging from 10 to 1,000 ng/ml. From these results, it is evident that dexamethasone induces ANX1 secretion into the culture medium and anti-ANX1 polyclonal antibody abolishes the effects of dexamethasone. Furthermore these results imply that extracellular ANX1 exerts its effects by binding to the receptor on the cell membrane and the activated signal(s) of ANX1R block IL-1B receptor signal in the lymphocytes.
Cell Membrane
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Dexamethasone
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Flow Cytometry
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Humans
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Interleukin-1*
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Lymphocyte Culture Test, Mixed
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Lymphocytes*
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Monocytes
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Signal Transduction
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T-Lymphocytes
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Tetradecanoylphorbol Acetate*
10.Infection Control Activities in Gil Medical Center.
Eun Sun LEE ; Shin Young PARK ; Yong Kyun CHO ; Yiel Hae SEO
Korean Journal of Nosocomial Infection Control 2004;9(1):49-56
No abstract available.
Infection Control*