1.Cyclophosphamide-Induced Hemorrhagic Cystitis in Acute Lymphocytic Leukemia and Non-Hodgkin Lymphoma.
Young Seo PARK ; Il Soo HA ; Soon Ki KIM ; Hae Il JUNG ; Yong SHOI ; Hyo Seop AHN
Journal of the Korean Pediatric Society 1989;32(5):665-669
No abstract available.
Cystitis*
;
Lymphoma, Non-Hodgkin*
;
Precursor Cell Lymphoblastic Leukemia-Lymphoma*
2.Three Cases of Cervical Necrotizing Fasciitis.
Young Hak PARK ; Hae Seop PARK ; Beom Cho JUN ; Seung Ho CHO
Korean Journal of Otolaryngology - Head and Neck Surgery 2002;45(4):416-421
Cervical necrotizing fasciitis (CNF) is an uncommon infection of the subcutaneous soft tissue and fascia. If proper treatment is delayed, the infection may cause extensive necrosis of overlying skin, extend to deeper planes and produce severe systemic toxicity. So an early diagnosis and a radical debridement of the affected tissue is imperative; however, the onset is often insidious in the form of nonspecific regional neck swelling, erythema and fever, rendering clinical distinction from more benign inflammatory conditions of the neck, such as cellulitis, may be impossible at an early stage. We present a series of 3 patients with CNF, each of whom had different clinical courses. One patient, with significant cormobidity at the time of presentation, died of CNF.
Cellulitis
;
Debridement
;
Early Diagnosis
;
Erythema
;
Fascia
;
Fasciitis, Necrotizing*
;
Fever
;
Humans
;
Neck
;
Necrosis
;
Skin
3.Exposure to Volatile Organic Compounds and Possibility of Exposure to By-product Volatile Organic Compounds in Photolithography Processes in Semiconductor Manufacturing Factories.
Seung Hyun PARK ; Jung Ah SHIN ; Hyun Hee PARK ; Gwang Yong YI ; Kwang Jae CHUNG ; Hae Dong PARK ; Kab Bae KIM ; In Seop LEE
Safety and Health at Work 2011;2(3):210-217
OBJECTIVES: The purpose of this study was to measure the concentration of volatile organic compound (VOC)s originated from the chemicals used and/or derived from the original parental chemicals in the photolithography processes of semiconductor manufacturing factories. METHODS: A total of four photolithography processes in 4 Fabs at three different semiconductor manufacturing factories in Korea were selected for this study. This study investigated the types of chemicals used and generated during the photolithography process of each Fab, and the concentration levels of VOCs for each Fab. RESULTS: A variety of organic compounds such as ketone, alcohol, and acetate compounds as well as aromatic compounds were used as solvents and developing agents in the processes. Also, the generation of by-products, such as toluene and phenol, was identified through a thermal decomposition experiment performed on a photoresist. The VOC concentration levels in the processes were lower than 5% of the threshold limit value (TLV)s. However, the air contaminated with chemical substances generated during the processes was re-circulated through the ventilation system, thereby affecting the airborne VOC concentrations in the photolithography processes. CONCLUSION: Tens of organic compounds were being used in the photolithography processes, though the types of chemical used varied with the factory. Also, by-products, such as aromatic compounds, could be generated during photoresist patterning by exposure to light. Although the airborne VOC concentrations resulting from the processes were lower than 5% of the TLVs, employees still could be exposed directly or indirectly to various types of VOCs.
Humans
;
Korea
;
Light
;
Parents
;
Phenol
;
Semiconductors
;
Solvents
;
Toluene
;
Transcutaneous Electric Nerve Stimulation
;
Ventilation
;
Volatile Organic Compounds
4.The prevalence of adverse drug reactions to a short course anti-tuberculosis regimen.
Sang Hoon KIM ; Byoung Hoon LEE ; Ki Deok LEE ; Jae Suk PARK ; Yun Seop KIM ; Young Koo JEE ; Sang Heon KIM ; Hae Sim PARK ; Kyoung Up MIN
Korean Journal of Medicine 2007;73(5):496-502
BACKGROUND: Anti-tuberculosis drugs used in combination cause adverse drug reactions, but the prevalence of the reactions and risk factors have not been determined. This study aims to identify the prevalence and risk factors of adverse drug reactions (ADR) to the use of first line anti-tuberculosis drugs. METHODS: A total of 435 newly diagnosed patients with tuberculosis (44.1 years+/-19.0 years) were eligible for this study. All patients received daily oral isoniazid (300 or 400 mg), rifampicin (450 or 600 mg) and ethambutol (800 mg) for 6 months, and pyrazinamide (20 mg/kg) for 2 months. Blood tests were performed regularly (before treatment, 2 weeks after treatment, and bimonthly there after). Patients were interviewed 2 months and 6 months after treatment. A serious ADR was defined as any ADR that resulted in the discontinuation of one or more of the drugs. RESULTS: An ADR was noted in 52.6% of all patients. Gastrointestinal (19.3%), cutaneous (17.7%), hepatic (13.8%), renal (12.6%), and neurological (10.3%) ADRs were frequent and hematological (4.4%), musculoskeletal (3.0%) ADRs were less frequent. A skin ADR was associated with an elevated baseline of liver enzymes (odds ratio, 3.48; 95% CI, 1.2 to 9.9), whereas a hepatic ADR was associated with a history of chronic liver disease (odds ratio, 4.82; 95% CI, 1.7 to 13.2). The prevalence of any serious ADR was 9.7%. Occurrence of any serious ADR was associated with a history of chronic liver disease (odds ratio, 4.29; 95% CI, 1.4 to 13.6). CONCLUSIONS: Anti-tuberculosis drugs given in combination frequently caused a ADR and the findings suggest that a patient receiving anti-tuberculosis treatment should be closely monitored.
Drug-Related Side Effects and Adverse Reactions*
;
Ethambutol
;
Hematologic Tests
;
Hepatitis
;
Humans
;
Isoniazid
;
Liver
;
Liver Diseases
;
Prevalence*
;
Pyrazinamide
;
Rifampin
;
Risk Factors
;
Skin
;
Tuberculosis
5.Kimura's Disease: 3 Cases.
Yoon Kyu PARK ; Ma Hae CHO ; Samuel LEE ; Joo Seop KIM ; Chan Heun PARK ; Eun Sook NAM ; Duck Hwan KIM ; Hyung Sik SHIN
Journal of the Korean Surgical Society 1999;56(4):608-614
Kimura's disease is a rare chronic inflammatory and proliferative condition of unknown etiology. It has been thought to be a part of large spectrum of the entity known as angiolymphoid hyperplasia with eosinophilia (ALHE). However, recently the difference is emphasized between the two entities by some authors. It usually presents subcutaneous or dermal mass in the head and neck region. This condition can be mistaken for a malignant tumor. It is defined pathologically as hyperplastic lymphoid follicles, eosinophilic infiltration and vascular proliferation. Authors have experienced three cases of Kimura's disease occurring in the submandibular, axillary and inguinal regions since 1993. There were two males and one female. Two patients presented peripheral eosinophilia. All patients underwent surgical excision. Two patients were managed with oral prednisone postoperatively.
Angiolymphoid Hyperplasia with Eosinophilia
;
Eosinophilia
;
Eosinophils
;
Female
;
Head
;
Humans
;
Male
;
Neck
;
Prednisone
6.The Radiographic Spectrum of Pulmonary Complications in Major Burn Patient.
Hae Kyoung JUNG ; Eil Seong LEE ; Ju Youn PARK ; Soo Hyun KIM ; Sung Hwan HONG ; Hong Suk PARK ; Kwan Seop LEE ; Ik Won KANG
Journal of the Korean Radiological Society 2000;42(4):637-642
In recent years, improved antibiotic care and physiologic fluid replacement in cases involving burn wounds have led to a decrease in the rate of fatalaties caused by wound sepsis and shock. There has, however, been an upsurge and relative increase in the frequency (15 -25%) and mortality rate (50 -89 %) of pulmonary complications. Since pulmonary lesions may result from direct injury to the respiratory tract caused by smoke inhalation, from circulatory, metabolic or infectious complications in cases involving cutaneous burns, or may develop during the therapeutic management of these lesions, a wide spectrum of pulmonary abnormalities can occur during the post-burn period. There is considerable overlap between their radiographic appearances, which are often nonspecific. Since the successful management of these patients is based on the early recognition and vig-orous treatment of lesions, familiarity with all facets of these complications, based on a pathophysiology of the injury and on the knowledge of the clinical setting, enables radiologists to make more specific diagnoses.
Burns*
;
Diagnosis
;
Humans
;
Inhalation
;
Mortality
;
Recognition (Psychology)
;
Respiratory System
;
Sepsis
;
Shock
;
Smoke
;
Wounds and Injuries
7.4 Cases of Duodenal Diverticular Bleeding Treated by Endoscopic Therapy.
Se Lim CHOI ; Hae Dong PARK ; Man Jo KIM ; Jung Seop EUM ; Young Seok LEE ; Dong Ju SONG ; Soo Hyun KIM ; Sung Min KIM ; Seong Ho CHOI ; Hee Seung PARK
Korean Journal of Gastrointestinal Endoscopy 2002;25(3):147-152
Duodenal diverticulum appears in 6% of upper gastrointestinal examinations and up to 23% of endoscopic retrograde cholangiopancreaticographies and up to 22% at autopsy. Most of these patients are asymptomatic, but a small fraction develop complications including choledocholithiasis, cholangitis, pancreatitis, diverticulitis, perforation, fistular formation and bleeding. Among these complications, only a few documented cases of bleeding have been reported in the literature, and the experience of endoscopist to the sequence of diagnosis, endoscopic treatment, and subsequent relief of the symptoms remains limited. Aggressive but careful endoscopic examination can help diagnosis of the cases. Also, endoscopic treatment of duodenal diverticular bleeding is very effective and proved to be an effective alternative to surgery. We report 4 patients with duodenal diverticular bleeding in whom both diagnosis and definitive treatment were successful by endoscopy alone.
Autopsy
;
Cholangitis
;
Choledocholithiasis
;
Diagnosis
;
Diverticulitis
;
Diverticulum
;
Endoscopy
;
Hemorrhage*
;
Humans
;
Pancreatitis
8.The Relationship between the Cognitive Impairment and Mortality in the Rural Elderly.
Byung Hwan SUN ; Kyeong Soo PARK ; Baeg Ju NA ; Yo Seop PARK ; Hae Sung NAM ; Jun Ho SHIN ; Seok Joon SOHN ; Jung Ae RHEE
Korean Journal of Preventive Medicine 1997;30(3):630-642
The purpose of this study was to examine the mortality risk associated with cognitive impairment among the rural elderly. The subjective of study was 558 of 'A Study on the Depression and Cognitive Impairment in the Rural Elderly' of Jung Ae Rhee and Hyang Gyun Jung's study(1993). Cognitive impairment and other social and health factors were assessed in 558 elderly rural community residents. For this study, a Korean version of the Mini-Mental State Examination(MMSEK) was used as a global indicator of cognitive functioning. And mortality risk factors for each cognitive impairment subgroup were identified by univariate and multivariate Cox regression analysis. At baseline 22.6% of the sample were mildly impaired and 14.2% were severely impaired. As the age increased, the cognitive function was more impaired. Sexual difference was existed in the cognitive function level. Also the variables such as smoking habits, physical disorders had the significant relationship with cognitive function impairment. Across a 3-year observation period the mortality rate was 8.5% for the cognitively unimpaired, 11.1% for the mildly impaired, and 16.5% for the severly impaired respondents. And the survival probability was .92 for the cognitively unimpaired, .90 for the mildly impaired, and .86 for the severly impaired respondents. Compared to survival curve for the cognitively unimpaired group, each survival curve for the mildly and the severely impaired group was not significantly different. When adjustments models were not made for the effects of other health and social covariates, each hazard ratio of death of mildly and severely impaired persons was not significantly different as compared with the cognitively unimpaired. But, as MMSEK score increased, significantly hazard ratio of death decreased. Employing Cox univariate proportional hazards model, statistically other significant variables were age, monthly income, smoking habits, physical disorders. Also when adjustments were made for the effects of other health and social covariates, there was no difference in hazard ratio of death between those with severe or mild impairment and unimpaired persons. And as MMSEK score increased, significantly hazard ratio of death did not decrease. Employing Cox multivariate proportional hazards model, statistically other significant variables were age, monthly income, physical disorders. Employing Cox multivariate proportional hazards model by sex, at men and women statistically significant variable was only age. For both men and women, also cognitive impairment was not a significant risk factor. Other investigators have found that cognitive impairment is a significant predictor of mortality. But we didn't find that it is a significant predictor of mortality. Even though the conclusions of our study were not related to cognitive impairment and mortality, early detection of impaired cognition and attention to associated health problems could improve the quality of life of these older adults and perhaps extend their survival.
Adult
;
Aged*
;
Cognition
;
Surveys and Questionnaires
;
Depression
;
Female
;
Humans
;
Male
;
Mortality*
;
Proportional Hazards Models
;
Quality of Life
;
Research Personnel
;
Risk Factors
;
Rural Population
;
Smoke
;
Smoking
9.Effects of Peritonsillar Infiltration with Bupivacaine and Oral Dextromethorphan on Post-Tonsillectomy Pain.
Dae Gun JUNG ; So Young PARK ; Hae Seop PARK ; Shi Hyung LEE ; Phil Kyu LIM ; Ju Eun CHO
Korean Journal of Otolaryngology - Head and Neck Surgery 1999;42(8):1031-1034
BACKGROUND AND OBJECTIVES: Peripheral tissue or nerve injury often leads to post-injury pain hypersensitivity caused by peripheral and central sensitization. Central sensitization which plays a significant role is triggered by nociceptive afferent inputs and mainly results from N-methyl-D-aspartic acid (NMDA) receptor activation. If the afferent impulses are prevented from gaining access to the CNS or if NMDA receptor is blocked by antagonist, central sensitization will not develop and then less pain will result. Previous studies demonstrated that preoperative infiltration of local anesthetics or oral NMDA receptor antagonist could alleviate postoperative pain. We investigated the effects of peritonsillar infiltration with bupivacaine and oral dextromethorphan on post-tonsillectomy pain. MATERIALS AND METHODS: Forty consecutive patients were randomly allocated to one of four groups. Group I was bupivacaine-treated group, and group II was dextromethorphan-treated group. Group III was both bupivacaine and dextromethorphan-treated group, and group IV was control group. Pain scores were assessed using self-rating numeric rating scale ( NRS) at rest and on swallowing during the postoperative day 0, 1, 2, and 7. Doses of supplementary diclofenac administered postoperatively were also recorded. RESULTS: Group I, II, and III showed significantly lower NRS pain scores compared with control group at rest and on swallowing throughout the postoperative 7 days. Diclofenac doses were not statistically different among the four groups. CONCLUSION: Preoperative peritonsillar infiltration with bupivacaine and/or medication with dextromethorphan contributed to decrease the intensity of postoperative pain after tonsillectomy.
Anesthetics, Local
;
Bupivacaine*
;
Central Nervous System Sensitization
;
Deglutition
;
Dextromethorphan*
;
Diclofenac
;
Humans
;
Hypersensitivity
;
N-Methylaspartate
;
Pain, Postoperative
;
Tonsillectomy
10.Relationship of Serum Cholesterol and Anxiety in Rural Residents.
Yp Seop PARK ; Kyeong Soo PARK ; Baeg Ju NA ; Hae Sung NAM ; Jun Ho SHIN ; Seok Joon SOHN ; Jin Su CHOI ; Byong Woo KIM
Korean Journal of Preventive Medicine 1997;30(3):489-496
In other to study relationship of anxiety and serum cholesterol in general population, we performed the interview survey and screening test for the Ju-am cohort and residents in controlling area at 1995. Among them, 622 people are selected for this analysis. The results were summarized as follows. 1. Anxiety and total serum cholesterol related each other in the group of anxiety. Correlation coefficient was 0.39(p<0.01). 2. According to the result of multiple regression that the total serum cholesterol regarded as the dependent variable, anxiety and total serum cholesterol were related each other positively in the group of anxiety(p<0.05). 3. As the symptoms of anxiety was dichotomized affective and somatic symptom. There was no relationship of 2 symptoms and total serum cholesterol in all subjects, but there was more relationship on the affective symptom than on the somatic symptom in the group of anxiety(p<0.05). The above results show that anxiety and total serum cholesterol related each other significantly in the anxiety group. And the relationship of psychological factors and serum cholesterol could be applied significantly in general population as well as in the special group.
Affective Symptoms
;
Anxiety*
;
Cholesterol*
;
Cohort Studies
;
Mass Screening
;
Psychology