1.A Case of Autoimmune Hemolytic Anemia Associated with Acute Viral Hepatitis B.
Chong Kyu WOO ; Eun Kyung CHOI ; Hae Ryung CHUNG ; Dong Heuk KEUM
Journal of the Korean Pediatric Society 1987;30(9):1034-1039
No abstract available.
Anemia, Hemolytic, Autoimmune*
;
Hepatitis B*
;
Hepatitis*
2.The Usefulness of CO2 Indirect Portography in Transjugular Intrahepatic Portosystemic Shunt(TIPS).
Hae Jun YANG ; Hae Giu LEE ; Ie Ryung YOO ; Kyung Joo LEE ; Myung Hee CHUNG ; Won Jong YU ; Yeo Dong YOON ; Seog Hee PARK ; Young Sok LEE ; Nam Ik HAN
Journal of the Korean Radiological Society 1999;41(5):899-902
PURPOSE: To determine the usefulness of carbon dioxide(CO2) indirect portography during TIPS procedure. MATERIALS AND METHODS: We evalvated eight patients who had undergone TIPS due to variceal hemorrhage or ascites caused by portal hypertension. All patients but one with complete situs inversus underwent wedged right hepatic venography for visualization of the portal vein using CO2. For CO2 indirect portal venography, 50cc of CO2 was injected by hand without prior injection of a small amount of CO2. In three patients a 5-F angiographic catheter was wedged into the right hepatic vein, and in the other five a 9-F sheath from a Ring 's transjugular access set was adjunctively wedged into the right hepatic vein over the 5-F catheter. The time required for portal vein puncture was defined as the time between the indirect portal venography procedure and the first procedure after successful portal vein puncture. RESULTS: All patients successfully underwent TIPS without any immediate complication. The portal vein was visualized by CO2 in 7 of 8 patients (87.5 %). Two of three patients who underwent indirect portography with only a 5-F catheter wedging demonstrated opacification of the right portal vein; in the remaining patient the portal venous system was not visualized. Of the five patients who underwent indirect portography with an adjunctive 9-F sheath wedged in the right hepatic vein, four showed opacification from the peripheral to the main portal vein, and in the other, the only right peripheral portal vein was opacified. The mean time for portal vein puncture was 20.5 minutes. CONCLUSION: For visualization of the portal venous system during TIPS procedure, the use of CO2 indirect portography is feasible.
Ascites
;
Carbon
;
Carbon Dioxide
;
Catheters
;
Hand
;
Hemorrhage
;
Hepatic Veins
;
Humans
;
Hypertension, Portal
;
Phlebography
;
Portal Vein
;
Portasystemic Shunt, Surgical
;
Portography*
;
Punctures
;
Situs Inversus
3.Assessment of Cerebrovascular Reserve before and after STA-MCA Bypass Surgery by SPECT and SPM Analysis.
Joo Hyun O ; Kyung Sool JANG ; Ie Ryung YOO ; Sung Hoon KIM ; Soo Kyo CHUNG ; Hyung Sun SOHN ; Hyung Kyun RHA ; Hae Kwan PARK ; Yong An CHUNG ; Jaeseung JEONG
Korean Journal of Radiology 2007;8(6):458-465
OBJECTIVE: The purpose of this study was to objectively assess the efficacy of superficial temporal artery to middle cerebral artery (STA-MCA) bypass surgery using Technetium (Tc)-99m-ethyl cysteinate dimer (ECD) single photon emission computed tomography (SPECT) in patients who underwent STA-MCA bypass surgery. MATERIALS AND METHODS: Brain perfusion SPECT images obtained at baseline and after the administration of acetazolamide were reconstructed using statistical parametric mapping in 23 patients, both before and after STA-MCA bypass surgery. The clinical outcomes of the surgery were also recorded and compared with the hemodynamic changes. A voxel with an uncorrected p-value of less than 0.001 was considered to be statistically significant. RESULTS: SPECT images of the territory supplied by the bypass graft showed an increase in both cerebrovascular flow and reserve at baseline, and the increase was significantly higher following the administration of acetazolamide. All patients showed improvement of clinical symptoms and increased blood flow to the left temporal, parietal, and frontal cortices as well as the thalamus. CONCLUSION: Brain SPECT effectively and objectively demonstrated the improved outcomes of STA-MCA bypass surgery, and thus may be used in postoperative analyses.
Acetazolamide/diagnostic use
;
Adult
;
Aged
;
Brain/*radionuclide imaging
;
Brain Mapping/methods
;
Carotid Stenosis/surgery
;
*Cerebral Revascularization
;
*Cerebrovascular Circulation
;
Cysteine/analogs & derivatives/diagnostic use
;
Female
;
Follow-Up Studies
;
Humans
;
Image Processing, Computer-Assisted
;
Intracranial Arteriosclerosis/surgery
;
Male
;
Middle Aged
;
Middle Cerebral Artery/*surgery
;
Models, Statistical
;
Organotechnetium Compounds/diagnostic use
;
Predictive Value of Tests
;
Radiopharmaceuticals/diagnostic use
;
Temporal Arteries/*surgery
;
Tomography, Emission-Computed, Single-Photon/*methods
;
Treatment Outcome
4.PTEN Promoter Hypermethylation Is Associated with Breslow Thickness in Acral Melanoma on the Heel, Forefoot, and Hallux
Hae Seok PARK ; Jong Hoon KIM ; Mi Yeon CHO ; Kee Yang CHUNG ; Mi Ryung ROH
Annals of Dermatology 2021;33(1):18-25
Background:
Acral melanoma occurs on glabrous skin or the nail apparatus and is distinct from ultraviolet-related melanoma due to differing genetic alteration patterns. Although the pathogenesis of acral melanoma is not well understood, mechanical stress is thought to induce acral melanoma. The incidence of gene mutation and promoter methylation has been reported in tumors from acral melanoma; however, an association between genetic/epigenetic alterations and mechanical stress in acral melanoma remains unclear.
Objective:
To investigate the relationship between clinical/genetic factors and mechanical stress in acral melanoma.
Methods:
A retrospective review of 52 patients diagnosed with acral melanoma was performed. We reviewed the clinical characteristics of patients, tumor status, and tumor location. Mutations in BRAF, NRAS, and the TERT promoter, along with KIT amplification and PTEN promoter methylation were analyzed in the tumors.
Results:
The heel (34/52, 65.4%) was the most common anatomical tumor site. Mutations in BRAF (6/48, 12.5%), NRAS (6/49, 12.2%), and the TERT promoter (4/33, 12.1%), along with KIT,/i> amplification (3/37, 8.1%) and PTEN promoter hypermethylation (12/48, 25.0%) were ob-served in the tumors. On the forefoot, heel, and hallux, PTEN promoter hypermethylation was significantly associated with Breslow thickness (p=0.001) and ulceration rate (p= 0.042). On the midfoot and lesser toes, there was no significant difference in Breslow thickness or ulceration rate regardless of PTEN promoter hypermethylation (p>0.05).
Conclusion
PTEN promoter hypermethylation is associated with Breslow thickness and tumor ulceration on the forefoot, heel, and hallux in acral melanoma in Korean patients.
5.An Open-Label, Randomized, Parallel, Phase III Trial Evaluating the Efficacy and Safety of Polymeric Micelle-Formulated Paclitaxel Compared to Conventional Cremophor EL-Based Paclitaxel for Recurrent or Metastatic HER2-Negative Breast Cancer.
In Hae PARK ; Joo Hyuk SOHN ; Sung Bae KIM ; Keun Seok LEE ; Joo Seop CHUNG ; Soo Hyeon LEE ; Tae You KIM ; Kyung Hae JUNG ; Eun Kyung CHO ; Yang Soo KIM ; Hong Suk SONG ; Jae Hong SEO ; Hun Mo RYOO ; Sun Ah LEE ; So Young YOON ; Chul Soo KIM ; Yong Tai KIM ; Si Young KIM ; Mi Ryung JIN ; Jungsil RO
Cancer Research and Treatment 2017;49(3):569-577
PURPOSE: Genexol-PM is a Cremophor EL–free formulation of low-molecular-weight, non-toxic, and biodegradable polymeric micelle-bound paclitaxel. We conducted a phase III study comparing the clinical efficacy and toxicity of Genexol-PM with conventional paclitaxel (Genexol). MATERIALS AND METHODS: Patients were randomly assigned (1:1) to receive Genexol-PM 260 mg/m² or Genexol 175 mg/m² intravenously every 3 weeks. The primary outcome was the objective response rate (ORR). RESULTS: The study enrolled 212 patients, of whom 105 were allocated to receive Genexol-PM. The mean received dose intensity of Genexol-PM was 246.8±21.3 mg/m² (95.0%), and that of Genexol was 168.3±10.6 mg/m² (96.2%). After a median follow-up of 24.5 months (range, 0.0 to 48.7 months), the ORR of Genexol-PM was 39.1% (95% confidence interval [CI], 31.2 to 46.9) and the ORR of Genexol was 24.3% (95% CI, 17.5 to 31.1) (p(non-inferiority)=0.021, p(superiority)=0.016). The two groups did not differ significantly in overall survival (28.8 months for Genexol-PM vs. 23.8 months for Genexol; p=0.52) or progression-free survival (8.0 months for Genexol-PM vs. 6.7 months for Genexol; p=0.26). In both groups, the most common toxicities were neutropenia, with 68.6% occurrence in the Genexol-PM group versus 40.2% in the Genexol group (p < 0.01). The incidences of peripheral neuropathy of greater than grade 2 did not differ significantly between study treatments. CONCLUSION: Compared with standard paclitaxel, Genexol-PM demonstrated non-inferior and even superior clinical efficacy with a manageable safety profile in patients with metastatic breast cancer.
Breast Neoplasms*
;
Breast*
;
Disease-Free Survival
;
Follow-Up Studies
;
Humans
;
Incidence
;
Neutropenia
;
Paclitaxel*
;
Peripheral Nervous System Diseases
;
Polymers*
;
Treatment Outcome