1.A Comparison of 10% Lidocaine Spray and Intravenous 2% Lidocaine on Mean ArterialPressure and Heart Rate Following Tracheal Intubation.
Jung Man LIM ; Young Keun CHAE ; Dae Hyun JO ; Hae Kyoung KIM ; Choon Kun CHUNG
Korean Journal of Anesthesiology 1997;33(4):633-638
BACKGROUND: Laryngoscopy and tracheal intubation for general anesthesia are potent stimuli to the cardiovascular system due to sympathetic stimulation. The aim of this study was to compare the hemodynamic responses with different administration routes of lidocaine on blood pressure and heart rate changes associated with tracheal intubation. METHODS: Sixty patients were randomly assigned to spray group (Group 1, n=20) received 10% lidocaine 1.5 mg/kg spray to intratracheally immediately before tracheal intubation, IV group (Group 2, n=20) received 2% lidocaine 1.5 mg/kg intravenously before 90 sec tracheal intubation and control group (Group 3, n=20). Anesthesia was induced with thiopental 5 mg/kg IV, vecuronium 0.1 mg/kg and 50% N2O-O2- 2vol % enflurane. After 5 minutes, tracheal intubation was performed. Mean arterial pressure and heart rate were measured at preintubation and immediately postintubation, 1, 3, 5 mins after tracheal intubation. RESULTS:The differences of mean arterial pressure which were measured at preintubation and immediately postintubation and 1 minute after intubation in group 1 were significantly lower than those in other group (p<0.05). The differences of heart rate which measured at preintubation and 1 minute after intubation were lower than those in group 3 (p<0.05). CONCLUSIONS: For the suppression of sympathetic stimulation following tracheal intubation, 10% lidocaine spray to the laryngotrachea is an effective method to suppress cardiovascular response.
Anesthesia
;
Anesthesia, General
;
Arterial Pressure
;
Blood Pressure
;
Cardiovascular System
;
Enflurane
;
Heart Rate*
;
Heart*
;
Hemodynamics
;
Humans
;
Intubation*
;
Laryngoscopy
;
Lidocaine*
;
Thiopental
;
Vecuronium Bromide
2.Histopathologic changes of the craniomandibular joint according to the amount of distraction after 6 weeks of distraction osteogenesis in rabbits.
Hyun Ho KIM ; Su Gwan KIM ; Sung Chul LIM ; Hae Man CHUNG ; Sang Gon KIM
Journal of the Korean Association of Oral and Maxillofacial Surgeons 2003;29(2):79-85
The purpose of this study is to observe histopathologic changes in the bilateral craniomandibular joints after allowing 6 weeks of consolidation by varying the amount of distraction in rabbit mandible. Eight rabbits weighing about 2 to 3kg were used. After corticotomy was performed on the left mandibular body between the first premolar and the second premolar region, a unilateral fixation device was placed. Then, a 7-day period was allowed without distraction of the device. The mandible was lengthened 0.5mm/day. Corticotomy and lengthening of mandible were not performed in control group. After the completion of the lengthening process, a 6-week-consolidation period was allowed. Then, the rabbits were sacrificed, and histologic examination of the craniomandibular joints was performed. Proliferative changes were observed in the craniomandibular joints in all groups. With the increasing amount of distraction, hypertrophy of the cartilage layer became more severe, bone formed was dense and enchondral ossification was clearly shown in subchondral bone. Hypertrophy of the cartilage layer was also seen in the non-distracted side as the distracted side in the experimental group. These results indicate that when physical force is applied constantly to joints, the proliferation of articular cartilage and bone formation are present. When more than 6 weeks of consolidation period is allowed at the time of performing distraction for more than 5mm, articular changes, especially, in the contralateral side should also be noted.
Bicuspid
;
Cartilage
;
Cartilage, Articular
;
Hypertrophy
;
Joints*
;
Mandible
;
Osteogenesis
;
Osteogenesis, Distraction*
;
Rabbits*
3.An experimental study on the effect of 5-Thio-D-Glucose on radiation injury after hyperthermia
Hae Soon CHANG ; Man Chung HAN ; Chu Wan KIM ; Charn Il PARK
Journal of the Korean Radiological Society 1982;18(1):17-26
To evaluate the influence of 5-thio-D-glucose on irradiation effect after hyperthermia, an experimental study was carried out using a total of 72 mice. A single dose of 3000 rads was delivered on skin of mouse tail after hyperthermia with or without intraperitoneal injection of 5-thio-D-glucose 2 hours before irradiation. The hyperthermia was carried out at 43degrees C for 40 minutes just before the irradiation. The skin changes of their radiatied mouse tail were observed from 7th to 31st post-irradiation days, and the scores were anlayzed. Theresults are as follows; 1. Radiation damage on mouse skin increased significantly when radiation was combined withhyperthermia. 2. In the group of 5-thio-D-glucose and irradiation after hyperthermia, radiation damage on mouseskin significantly decreased than in the group without 5-thio-D-glucose. 3. 5-thio-D-glucose appears to be apotential radioprotective agent in clinical radiotherapy with hyperthermia.
Animals
;
Fever
;
Injections, Intraperitoneal
;
Mice
;
Radiation Injuries
;
Radiotherapy
;
Skin
;
Tail
4.Iatrogenic dissection of the celiac artery and its branches during TAE for HCC: results of follow-up in 30 cases.
Dae Young YOON ; Jae Hyung PARK ; Jin Wook CHUNG ; Joon Koo HAN ; Chang Hae SUH ; Man Chung HAN
Journal of the Korean Radiological Society 1993;29(1):86-94
The authors analyzed 30 patients whose celiac artery or its branches were dissected during the procedure of transcatheter arterial embolization (TAE) for hepatocellular carcinoma (HCC) and were followed up angiographically. The incidence of arterial dissection was 1.25%. The dissection occurred most frequently in the celiac artery (40% 12/30) and the proper hepatic artery(28% 7/30). The frequency of arterial dissection was affected by the status of the vessel and the experience of the operator. The follow-up angiography revealed complete recanalization in 40% (12/30), irregularity and narrowing of the lumen in 23% (7/30), pseudoaneurysm formation in 23%(7/30), and complete obstruction in 13% (4/30) of the cases. The rate of recanalization in the celiac artery was lower than that of any other arteries in our series. Recamalization to a certain degree without therapeutic intervention was observed in 72% of the dissected arteries enabling and contributing to subsequent successful TAE within 2 months in 78% of the patients with the dissection.
Aneurysm, False
;
Angiography
;
Arteries
;
Carcinoma, Hepatocellular
;
Celiac Artery*
;
Follow-Up Studies*
;
Humans
;
Incidence
6.Two Cases of Spontaneous Rupture of the Kidney.
Nak Kyu CHOI ; Tae Eui HONG ; Chin Ha LEE ; Hwang CHOI ; Hae Soon JANG ; Sung Yel YOO ; Man Chung HAN
Korean Journal of Urology 1973;14(4):331-335
Two cases of spontaneous kidney rupture with literatural review was presented at first in Korea. 1) 56 years male patient and 25 years male patient admitted to our department of Urology through Emergency Room after onset of 2 and 1 day. after treatment at local clinic. 2) Chief complaints were one side flank pain which was followed by total gross hematuria. 3) Preoperative diagnoses were kidney rupture due to necrotic pelvic tumor in 56 years male and hypernephroma in 25 years male patient. 4) Operation was procedured at 8 days and 4 days after admission respectively. 5) The operative procedure were nephrectomy in both cases. 6) The pathological diagnoses were pelvis rupture due to renal stone and parenchymal rupture due to renal infarction in each case.
Carcinoma, Renal Cell
;
Diagnosis
;
Emergency Service, Hospital
;
Flank Pain
;
Hematuria
;
Humans
;
Infarction
;
Kidney*
;
Korea
;
Male
;
Nephrectomy
;
Pelvis
;
Rupture
;
Rupture, Spontaneous*
;
Surgical Procedures, Operative
;
Urology
7.Effects of both Clonidine Premedication and Esmolol Administration on the Hemodynamic Changes by Tracheal Intubation.
Jung Man LIM ; Hae Kyoung KIM ; Choon Kun CHUNG
Korean Journal of Anesthesiology 1998;35(6):1061-1067
BACKGROUND: Tracheal intubation by direct laryngoscopy induces frequently transient hypertension, tachycardia and arrhythmia. The purpose of this study was to examine the effect of esmolol and clonidine in attenuating the changes of blood pressure and heart rate by tracheal intubation. METHODS: Eighty patients were randomly divided into four groups: Group 1 (control , n=20), Group 2 (esmolol 0.5 mg/kg IV, n=20), Group 3 (clonidine 4 mcg/kg PO, n=20) and Group 4 (clonidine 4 mcg/kg PO and esmolol 0.5 mg/kg IV, n=20). The clonidine premedication were given orally with a sip of water 90 minutes before induction of anesthesia. Anesthesia was induced with thiopental 5 mg/kg, vecuronium 0.1 mg/kg, 50% nitrous oxide in oxygen and 2 vol % enflurane. After 5 minutes, tracheal intubation was performed. Patients in the group 2 and group 4 were given esmolol 0.5 mg/kg 90 seconds prior to tracheal intubation. Blood pressure and heart rate were measured at ward, preinduction, preintubation, immediately after intubation, 1, 3 and 5 minutes after intubation. RESULTS: After tracheal intubation, the increase in systolic blood pressure was supressed significantly in the clonidine-treated patients (Group 3, Group 4) compared with control group (p<0.05). The attenuating effect on increase of mean arterial pressure(MAP) was sustained longer in group 4 than group 3. Heart rate increased after tracheal intubation in all groups, but were markedly increased in the control group (p<0.05). The differences of MAP which measured at preinduction and immediately postintubation were smaller in group 4 than control group (p<0.05). The differences of heart rate which measured at preinduction and immediately postintubation were smaller in group 4 than group 1 or group 3 (p<0.05). CONCLUSIONS: Esmolol 0.5 mg/kg given as bolus, is effective for controlling the increase of heart rate but not in attenuating increase of blood pressure. Oral clonidine is effective for controlling the increase of blood pressure but not in attenuating increase of heart rate. Therefore esmolol combined with oral clonidine results in effective control of both heart rate and blood pressure.
Anesthesia
;
Arrhythmias, Cardiac
;
Blood Pressure
;
Clonidine*
;
Enflurane
;
Heart Rate
;
Hemodynamics*
;
Humans
;
Hypertension
;
Intubation*
;
Laryngoscopy
;
Nitrous Oxide
;
Oxygen
;
Premedication*
;
Tachycardia
;
Thiopental
;
Vecuronium Bromide
;
Water
8.Diagnosis of hepatic hemangioma with 99mTc-labeled red cells and single photon emission computed tomography (SPECT).
Dae Hyuk MOON ; Shee Man CHO ; Myung Hae LEE ; Suck Kyun YANG ; Young Hwa CHUNG ; Yung Sang LEE ; Sung Hae SHIN ; Kee Suk HONG
Korean Journal of Nuclear Medicine 1991;25(1):68-75
No abstract available.
Diagnosis*
;
Hemangioma*
;
Tomography, Emission-Computed, Single-Photon*
9.Carcinosarcoma (True Malignant Mixed Tumor) of the Parotid Gland: A Report of a Case with Small Cell Carcinoma as the Carcinoma Component.
Hun Soo KIM ; Hyang Jung CHO ; Yeun Tai CHUNG ; Soon Ah PARK ; Hae Joong CHO ; Jin Man KIM
Korean Journal of Pathology 2008;42(3):175-180
True malignant mixed tumor (carcinosarcoma) of the salivary gland is an extremely rare tumor. By definition, it is a heterologous neoplasm that's composed of both malignant epithelial and mesenchymal components. We report here on a case of an 83 year old female patient with a parotid gland mass. Histologic examination showed a biphasic pattern of growth with both a poorly differentiated epithelial component and a sarcomatous spindle cell background. The immunohistochemical and ultrastructural findings support the diagnosis of a small cell neuroendocrine epithelial tumor and an undifferentiated malignant mesenchymal features. The histologic and ultrastructural features along with the immunohistochemical findings are presented. We also review the literature and we discuss the different opinions on the exact histogenesis of the true malignant mixed tumor of the salivary gland. To the best of our knowledge, this histological pattern has not been previously reported in the English medical literature.
Female
;
Humans
10.Effects of Carvedilol on Left Ventricular Function in Elderly Patients with Congestive Heart Failure.
In Sook KIM ; Sang Man CHUNG ; Jong Hyok LEE ; Jung Yon LEE ; Hae Ryon AHN ; Sung Ryul KIM ; Hae Woon LEE
Journal of the Korean Society of Echocardiography 2001;9(1):31-27
BACKGROUND AND OBJECTIVES: Neurohormonal compensation plays an important role on the pathophysiologic aspects of congestive heart failure (CHF). There is recent clinical evidence that beta blocker is beneficial in selected patients. However, there is little information regarding the effect of beta blocker on elderly patients. MATERIALS AND METHODS: 26 patients of CHF under stable condition by conventional management were selected and were divided into two age subgroup. Group 1 were more than 65 years (n=12) and group 2 were less than 65 years (n=14). From 12.5 to 25 mg/day of carvedilol was given according to the clinical condition. The left ventricular end diastolic dimension (LVEDD), left ventricular end systolic dimension (LVESD), left ventricular volume index (LVVI), ejection fraction (LVEF), E/A ratio and E wave deceleration time (EwDT) of mitral inflow doppler velocity were measured by echocardiographic examination before and 3 months after carvedilol trial. Six-minute walk distance were also measured. RESULTS: Between before and after carvedilol treatment, there were significant decrease of LVVI and sign-ificant increase of EF in group I and group II. The EwDT and 6 minute walk distance of both group were also increased significantly after carvedilol trial. The delta EF of group I is smaller than group II (4.1+/-5.7 vs 9.7+/-10.0, p<0.05). CONCLUSION: When compared to younger patients with CHF, the efficacy of carvedilol on LV function in aged patients was evident. Improved clinical conditions would be expected by using carvedilol in elderly patients with CHF.
Aged*
;
Compensation and Redress
;
Deceleration
;
Echocardiography
;
Estrogens, Conjugated (USP)*
;
Heart Failure*
;
Humans
;
Ventricular Function, Left*