1.An association between elevated second-trimester human chorionic gonadotropin and subsequent preeclampsia.
Korean Journal of Obstetrics and Gynecology 1999;42(10):2348-2352
OBJECTIVES: The purpose of this investigation was to determine whether women with unexplained elevations of maternal serum human chorionic gonadotropin(hCG) at 14-20weeks gestation are at incresed risk for poor pregnancy outcomes. METHODS: 661 pregnant women undergoing second trimester triple marker screening test for Down syndrome and neural tube defect and delivered at our hospital were reviewed. Of 656 pregnancies that did not have maternal serum alpha feto-protein> or =2.5 multiples of the median(MoM), risk for poor pregnancy outcomes include to preeclampsia, preterm delivery, preterm rupture of membrane(PROM), small for gestational age(SGA) and fetal distress was evaluated in women with elevated hCG(> or =2.0 MoM) compared with women without elevated hCG(<2.0 MoM). RESULTS: Pregnancies with elevated hCG levels were at increased risk for preeclampsia (risk ratio 3.4, 95% confidence interval 1.5-7.6) but elevated hCG levels were not significantly associated with preterm delivery, PROM, and SGA and fetal ditress independent with preeclampsia. CONCLUSION: Pregnancies with elevated second-trimester hCG appear to be at higher risk of subsequent preeclampsia and this finding supports the theory that placental vascular changes that ultimately lead to preeclampsia begin at least by the second trimester. But further studies must be to determine how such information can be used to improve pregnany outcome.
Chorion
;
Chorionic Gonadotropin*
;
Down Syndrome
;
Female
;
Fetal Distress
;
Humans*
;
Mass Screening
;
Neural Tube Defects
;
Pre-Eclampsia*
;
Pregnancy
;
Pregnancy Outcome
;
Pregnancy Trimester, Second
;
Pregnant Women
;
Rupture
2.A Case of Acute Generalized Exanthematous Pustulosis.
Hae Jin PARK ; Ho Jung KANG ; Jeong Hee HAHM
Korean Journal of Dermatology 1997;35(1):160-164
Acute generalized exanthematous pustulosis (AGEP) has symptoms of abrupt onset of a widespread pustular eruption on an erythematous. base. Most cases appear to be related to drug reactions, mainly antibiotics, but viral infections and hypersensitivity to mercury may cause AGEP. The essential features of AGEP include. (1) numerous (several dazen) small((5mm), mostly non follicular pustules arising on a widespread erythema:purpura and target-like lesions may be associated; (2) histology showing intraepidermal or subcorneal pustules associated with one or more of the following.clermal edema, vasculitis, perivascular eosinophils, or focal necrosis of keratinocytes; (3) fever (over 38C); (4) neutrophilia, and (5) acute evolution with spontaneous resulotion of pustules within 15 days. We report a case of AGEP which presented with widespread tiny pustules on the whole body except the face, palms and soles. There were petechia, purpura, and vesiculobullous lesions on the axilla, popliteal fossa and upper abdomen. A biopsy specimen from a pustule showed subcorneal pustules with perivascular polymorphous cellular infiltration, marked dermal edema and necrotic keratinocytes. There was complete resolution of the lesions within 10 days.
Abdomen
;
Acute Generalized Exanthematous Pustulosis*
;
Amoxicillin
;
Anti-Bacterial Agents
;
Axilla
;
Biopsy
;
Drug Eruptions
;
Edema
;
Eosinophils
;
Fever
;
Hypersensitivity
;
Keratinocytes
;
Necrosis
;
Purpura
;
Vasculitis
3.A Study on HBV Precore Mutant in Liver Tissues of Chronic Hepatitis B Patiets.
Hae Chul CHUNG ; Yeong Hong PARK ; Jung Myung CHUNG
The Korean Journal of Hepatology 1996;2(2):145-159
BACKGROUND/AIMS: In order to determine the relationship between the HBV precore mutant and the severity of liver disease in Korea, we performed liver biopsies in patients with HBV related chronic liver disease and compared the types of mutations and histologic findings in the same liver tissue simultaneously. METHODS: HBV DNA in liver tissues was amplified by polymerase chain reaction (PCR). The precore mutants were detected by PCR-SSCP(single strand conformation polymorphism), cloning the amplified PCR products and direct sequencing for them. RESULTS: 1. HBV DNA was detected in liver tissues of 28 cases among 30 patients with PCR. And with SSCP, the most cases were mixed type infections. 2. The HBV precore mutants were found in 12 cases among the total number of 28 cases(42.9%) and all mutations were G to A change at nucleotide 1896, creating a stop codon at codon 28. However, 10 cases among 12 mutants were associated with simultaneous another mutation at different positions or regions;9 cases at core gene region, 2 cases at nucleotide 1856(C to T change at codon 15), one case at core promoter, and one case with double mutations at nucleotide 1837 and 1846 respectively. Also, all HBV precore mutants were combined with wild type HBV sequence. 3. The relationship between HBV precore mutants and HBeAg status revealed that 4 cases from 13 HBeAg positive(30.8%) and 8 from 15 HBeAg negative or Anti-Hbe positive(53.3 %) were mutants. 4. In analysis of the types of mutants and histopathological findings of liver diseases, 6 among 15 chronic active hepatitis(40.0%), all 3 cases with hepatocellular carcinoma(100,0 %), 2 among 4 asymptomatic carriers with minimal histopathologic changes(50.0%) and a case with chronic lobular heaptitis(100.0%) showed precore region mutation. CONCLUSION: The patterns of HBV precore mutants in Korea could be summarized as followings. Firstly, most of the mutations are composed of G to A change at nucleotide 1896. Secondly, the most of the mutants at nuclmtide 1896 have been associated with simultaneous mutations at core promoter, core gene, and rarely at other positions, and manifested usua'ly mixed type viremic conditions. Thirdly, although precore mutation could be occurred in asymptomatic carrier, this type of mutation might be closely related with chronic or severe liver disease. However, it needs further investigations hereafter.
Biopsy
;
Clone Cells
;
Cloning, Organism
;
Codon
;
Codon, Terminator
;
DNA
;
Hepatitis B e Antigens
;
Hepatitis B, Chronic*
;
Hepatitis, Chronic*
;
Humans
;
Korea
;
Liver Diseases
;
Liver*
;
Polymerase Chain Reaction
;
Polymorphism, Single-Stranded Conformational
4.The orientation of facet joints and laminae of Korean in the lower lumbar spine.
In Jung CHAE ; Chang Yong HUH ; Hae Il PARK
The Journal of the Korean Orthopaedic Association 1991;26(4):1233-1237
No abstract available.
Spine*
;
Zygapophyseal Joint*
5.Molecular Mechanism of TNF-alpha and MMP-9 Production in Response to HIV-1 Core Antigen p24 in Human Monocytie THP-1 Cells.
Soon Ah SHIN ; Yoon Jung BAE ; Hyun Joo LEE ; Hae Kyung PARK ; Young Hae CHONG
Journal of Bacteriology and Virology 2001;31(4):369-377
No abstract available.
HIV-1*
;
Humans*
;
Tumor Necrosis Factor-alpha*
6.The diagnosis of mycoplasma pneumoniae pneumonia by high density composite particles agglutinin test.
Hae Jin CHOEH ; Jung Hae PARK ; Chong Sung CHUNG ; Kyu Chul CHOEH
Journal of the Korean Pediatric Society 1991;34(8):1102-1109
No abstract available.
Diagnosis*
;
Mycoplasma pneumoniae*
;
Mycoplasma*
;
Pneumonia*
;
Pneumonia, Mycoplasma*
7.Study on cord blood hemoglobin and etiology of neonatal anemia.
Chul LEE ; Hae Jung CHO ; Myung Ho LEE ; Sook Ja PARK ; Young Hae LEE
Journal of the Korean Pediatric Society 1982;25(9):906-913
No abstract available.
Anemia, Neonatal*
;
Fetal Blood*
;
Infant, Newborn
8.Four cases of malignant mixed mullerian tumors of uterus.
Jung Hee AHN ; Jong Chan PARK ; Min Jung OH ; Hae Jung KIM ; Kyu Wan LEE
Korean Journal of Obstetrics and Gynecology 1993;36(8):3343-3350
No abstract available.
Uterus*
9.Acute renal failure with back pain after exercise.
Hae Jung PARK ; Mi Jung KIM ; Dong Kyu JIN ; Hae Il CHEONG ; Yong CHOI ; Kwang Wook KO ; Jung Mi PARK ; Kyung Mo YEUN
Journal of the Korean Pediatric Society 1991;34(6):863-868
No abstract available.
Acute Kidney Injury*
;
Back Pain*
10.A Case of Perigraft Seroma in Chronic Hemodialysis Patient.
Ji Hoon KIM ; Hae Hyuk JUNG ; Kyoung Hyoub MOON ; In Suk SONG ; Jung Sik PARK
Korean Journal of Nephrology 1999;18(3):510-512
Perigraft seroma is uncommon complication of polytetrafluoroethylene(PTFE) grafts applied as an arteriovenous shunt for hemodialysis. It is a collection of clear, sterile fluid confined to nonsecretory fibrous pseudomembrane, most commonly localized around the middle and distal portion of graft. The possible etiologic factors of perigraft seroma include poor graft incorporation, mechanical graft damage caused by alcohol and povidone-iodine, intraoperative streching of the graft, variations in quality control at the time of manufacture and contributing factors such as anemia and coagulopathy in uremia. The best strategy for management of perigraft seroma is not clear. spiration or drainage alone is not effective, and some authors advocate graft removal. We report a case of perigraft seroma around arterial end of PTFE graft along with a brief review of the literatures.
Anemia
;
Drainage
;
Humans
;
Polytetrafluoroethylene
;
Povidone-Iodine
;
Quality Control
;
Renal Dialysis*
;
Seroma*
;
Transplants
;
Uremia