Many drugs have been known to induce lupus-like syndrome, composing approximately 10% of all SLE cases. Isoniazid-induced lupus erythematosus affects either sex equally and the most common presenting feature is arthralgia or arthritis with anemia. Fever and pleuritis occur in approximately half of the cases, and pericarditis in approximately 30% of cases. We discribe a 28-year-old woman receiving antituberculous medications including isoniazid for one month. She was hospitalized with fever, arthralgia and newly developed pleural effusion The analysis of pleural fluid and serum revealed an elevated level of antinuclear antibody. We suspected of drug induced lupus and stopped isoniazid medication. After discontinuation of isoniazid and short course of prednisolone treatment, her symptoms and pleural effusion disappeared. This case is to our knowledge, the fist report of isoniazid induced SLE in Korea.
Adult ; Anemia ; Antibodies, Antinuclear ; Arthralgia ; Arthritis ; Female ; Fever ; Humans ; Isoniazid* ; Korea ; Lupus Erythematosus, Systemic* ; Pericarditis ; Pleural Effusion ; Pleurisy ; Prednisolone

A renal angiomyolipoma is uncommon congenital mixed tumor like formations consisting of blood vessel, smooth muscle cells and adipose tissue. We report a case of retroperitoneal hemorrhage from spontaneous rupture of renal angiomyolipoma in a 37 year-old woman that appeared unilateral and pedunculated attached to renal cortex. The patient presented with a clinical feature of flank pain and shock because of massive hemorrhage. Because the patient suffered from flank pain regardless of selective renal embolization, laparoscopic surgery was necessary to remove angiomyolipoma from renal cortex.
Adipose Tissue ; Adult ; Angiomyolipoma* ; Blood Vessels ; Female ; Flank Pain ; Hemorrhage ; Humans ; Kidney Cortex ; Laparoscopy ; Myocytes, Smooth Muscle ; Rupture, Spontaneous ; Shock

Polyarteritis nodosa is a systemic vasculitis that affects mainly small and medium-sized muscular arteries. About half of the cases, it involves gastrointestinal tract, mainly jejunum and ileum. Major clinical manifestations are bleeding, ulcer, infection, necrosis, atrophy and stricture. Gastrointestinal involvement suggests a poor prognosis. We have experienced one case of polyarteritis nodosa involving entire gastrointestinal tract that showed various endoscopic features and confirmed by renal biopsy.
Arteries ; Atrophy ; Biopsy ; Colon ; Constriction, Pathologic ; Duodenum ; Gastrointestinal Tract* ; Hemorrhage ; Ileum ; Jejunum ; Necrosis ; Polyarteritis Nodosa* ; Prognosis ; Systemic Vasculitis ; Ulcer