1.Some biochemical and immunological characteristics in the patients with HIV and AIDS were treated at Bach Mai hospital
Journal of Vietnamese Medicine 2004;294(1):1-6
67 AIDS patients and 35 patients with HIV+ admited to National Institute for Clinical research of tropical diseases were investigated to determine the changes in some biochemical and immunological parameters. CD4 decreased in both groups of patients, but the AIDS patients have more decreased number of cells (AIDS: 99.5%; HIV+: 83.3%). CD8 increased (61.1%) or normal (38.9%) in the patients with HIV+, but decreased 15.5% and only increased 25% in the patients with AIDS. Total protein level was decreased in 33.3% of AIDS patients and 8.82% of HIV+ individuals. Albumin level severely decreased in both groups. Globulin concentration increased in both groups. The activities of GOT, GPT and LDH increased in both groups. Little changes was shown in the rest biochemical parameters
HIV
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Acquired Immunodeficiency Syndrome
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Therapeutics
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Diagnosis
2.Assessment of In vitro Antioxidant, Antidiabetic and Cytotoxic Activities of Sphaeranthus africanus Extracts
Tran Thi HUYEN ; Julien DUJARDIN ; Nguyen Thi THU HUONG ; Chung Thi MY DUYEN ; Nguyen Hoang MINH ; Ha Quang THANH ; Dao Tran MONG ; Ly Hai TRIEU ; Nguyen Mai TRUC TIEN ; Mai Thanh CHUNG ; Nguyen Nhat MINH ; Nguyen Thi NGOC DAN ; Huynh LOI
Natural Product Sciences 2023;29(2):98-103
Sphaeranthus africanus is commonly used as a traditional remedy for sore throats and pain treatment in Vietnam. The aerial parts have been studied for its anti-inflammatory and anti-proliferative properties. However, the antioxidant and antidiabetic potential of the plant has not been explored. In this work, hydrophilic extracts of the plant's aerial parts were prepared in order to investigate its antioxidant and anti-diabetic properties. Also, the cytotoxicity of the root was evaluated and compared to that of the aerial parts. All of the extracts inhibited lipid peroxidation with IC 50 values ranging from 2.05 to 3.56 µg/mL, indicating substantial antioxidant activity. At an IC 50 value of 4.80 μg/mL, the 50% ethanol extract exhibited the most potent inhibition of α-glucosidase. The cytotoxic activity of root extracts is 2 to 5-fold less than that of the aerial parts. Nevertheless, dichloromethane and ethyl acetate extracts of the root demonstrated a selective effect on leukemia cells, with no harm towards the normal HEK-293 cell line. This work provides a scientific support for the antioxidant and antidiabetic activity of the plant. Hence, it may find a promising material for the development of novel antioxidant and antidiabetic agents. More research can be conducted on the phytochemistry and anticancer activities of the plant’s root.