1.The Risk Factors Associated with Foot Re-Ulceration in Diabetes: A Retrospective Study Including Psychosocial Risk Factors.
Suk Ha JEON ; Mao Yuan SUN ; Su Young BAE
Journal of Korean Foot and Ankle Society 2012;16(2):108-115
PURPOSE: To evaluate several risk factors related to re-ulceration of diabetic foot including psychosocial aspects such as familial support and degree of independence of patients' activity. MATERIALS AND METHODS: We reviewed medical records and performed telephone interview with eighty-five patients who had a history of hospitalization in our hospital due to diabetic foot ulceration from year 2002 to 2010. Based on the collected data, we analyzed several factors such as age, gender, prevalence duration, accompanying diseases, HbA1c level, degree of independence and familial support. RESULTS: The mean age was 61.4 years and most common in the 4th decade. There were 57 cases (67%) of recurrence, predominance of male. Eleven patients with recurrent diabetic foot ulceration had undergone major amputations. Psychosocial problems such as depression, insufficient familial support and mortality were more frequently observed in recurrent group. CONCLUSION: This study shows that psychosocial factor such as familial support for patient with diabetic foot could be important to reduce the recurrence rate of diabetic foot ulceration. Therefore, we should pay attention to strategic plans for prevention, screening, treatment, and aftercare through the prospective studies including psychosocial risk factor in diabetic foot ulceration.
Aftercare
;
Amputation
;
Depression
;
Diabetic Foot
;
Foot
;
Hospitalization
;
Humans
;
Interviews as Topic
;
Male
;
Mass Screening
;
Medical Records
;
Prevalence
;
Recurrence
;
Retrospective Studies
;
Risk Factors
;
Ulcer
2.Breast Mass as a Manifestation of Ectopic Paragonimiasis: A case report.
Yung Suk LEE ; Seung Yeon HA ; Hyun I CHO ; Han Kyeom KIM ; Jung Won BAE ; In Sun KIM
Korean Journal of Pathology 1993;27(6):656-658
Paragonimus westermani can cause extrapulmonary parasitism in various sites such as abdominal organ, brain, eye, periorbital tissue, heart and pericardium, mediastinum, and subcutaneous tissue. We experienced a case of subcutaneous paragonimiasis involving the breast. The lesion exhibited chronic granuloma with scattered eggs of paragonimus westermani. The adult worm was not found within the lesion which should be disintegrated a year ago by praziquantel treatment. This relatively rare involvement of ectopic paragonimiasis should be differentiated from breast malignancy.
Adult
;
Male
;
Female
;
Humans
3.Prediction of Prognosis by Acetazolamide Brain Perfusion SPECT in Patients with Arteriovenous Malformation.
Sang Gyun BAE ; Jae Gon MOON ; Suk Mo LEE ; Han Gyu KIM ; Ha Yong YEOM ; Do Yoon HWANG
Korean Journal of Nuclear Medicine 2000;34(5):426-432
After surgical operation in patients with arteriovenous malformation (AVM), normal pressure perfusion breakthrough (NPPB) is one of the major complications. Brain perfusion SPECT with acetazolamide stress was known to be useful to evaluate the vascular reserve in several neurological and neurosurgical conditions. The authors performed acetazolamide brain perfusion SPECT in patients with AVM and compared the brain perfusion in the post-operative clinical courses. The acetazolamide brain perfusion SPECT was helpful in defining the prognosis of the patients with AVM. We describe 4 patients with AVM who had acetazolamide brain perfusion SPECT to examine the prognosis.
Acetazolamide*
;
Arteriovenous Malformations*
;
Brain*
;
Humans
;
Perfusion*
;
Prognosis*
;
Technetium Tc 99m Exametazime
;
Tomography, Emission-Computed, Single-Photon*
4.The Changes of Plantar Pressure and Pathway of Center of Pressure in Foot during the Gait in Normal Preschool Children with Age.
Ha Suk BAE ; Chang Il PARK ; Ji Cheol SHIN ; Ji Woong PARK
Journal of the Korean Academy of Rehabilitation Medicine 2001;25(6):1041-1047
OBJECTIVE: To find out the changes of the plantar pressure distribution of foot and the pathway of center of pressure (COP) in normal preschool children with age. METHOD: Thirty-eight normal children aged 1 to 6 were participated in this study. We divided into three groups according to the age. Foot contact area, pressure of the foot and pathway of COP were measured using F-scan in-shoe measuring system (Tekscan Inc.) during the gait. RESULTS: The ratio of midfoot contact width to forefoot contact width was decreased with age (p<0.05). And the relative pressure of the medial midfoot was decreased with age (p<0.05). In the analysis of COP, the ratio of anteroposterior length of COP to total contact length was significantly increased (p<0.05), and the ratio of mediolateral width of COP to forefoot contact width was tend to decrease. CONCLUSION: We can identify the characteristics and changes of the foot pressure distribution and the pathway of COP in preschool children with normal foot using F-scan system. These quantitative data of foot scan are useful for evaluating the foot pathology in preschool children during the gait.
Child
;
Child, Preschool*
;
Foot*
;
Gait*
;
Humans
;
Pathology
5.Axon Guidance Molecules Guiding Neuroinflammation
Won Suk LEE ; Won Ha LEE ; Yong Chul BAE ; Kyoungho SUK
Experimental Neurobiology 2019;28(3):311-319
Axon guidance molecules (AGMs), such as Netrins, Semaphorins, and Ephrins, have long been known to regulate axonal growth in the developing nervous system. Interestingly, the chemotactic properties of AGMs are also important in the postnatal period, such as in the regulation of immune and inflammatory responses. In particular, AGMs play pivotal roles in inflammation of the nervous system, by either stimulating or inhibiting inflammatory responses, depending on specific ligand-receptor combinations. Understanding such regulatory functions of AGMs in neuroinflammation may allow finding new molecular targets to treat neurodegenerative diseases, in which neuroinflammation underlies aetiology and progression.
Axons
;
Ephrins
;
Inflammation
;
Nervous System
;
Neurodegenerative Diseases
;
Neuroglia
;
Semaphorins
6.Appendiceal Intussusception Caused by Mucinous Cystadenocarcinoma.
Jung Min BAE ; Kyu Ha JUN ; Nak Hee KIM ; Jong Dae BAE ; Byung Ook JUNG ; Ki Hoon JUNG ; Sung Han BAE ; Woo Sup AHN ; Suk Jin CHOI ; Jung Ran KIM
Journal of the Korean Surgical Society 2003;64(4):348-352
An intussusception was first reported by Barbette in 1674, but an intussusception of the appendix was first reported in London, in 1858. Of all intussusceptions, 5% occur in adults, and of these 90% are as a result of a primary cause. Therefore, treatment is usually based on the primary cause. An intussusception of the appendix can be treated by barium or air reduction, or by an appendectomy, with manual reduction in pediatrics, but these are very uncommon in adult, and can be treated by various methods, according to the underlying cause. A 74 years old woman was preoperatively diagnosed, by radiological examination, to have an intussusception of the appendix. An exploratory laparotomy was performed, and the lesion confirmed as an intussusception caused by an appendix mass, which was cystic and filled with mucin. Therefore, a right hemicolectomy was performed, with the pathological results confirming a mucinous cystadenocarcinoma of the appendix. Here, we report a case of an adult intussusception of the appendix in a 74 years old woman.
Adult
;
Aged
;
Appendectomy
;
Appendix
;
Barium
;
Cystadenocarcinoma, Mucinous*
;
Female
;
Humans
;
Intussusception*
;
Laparotomy
;
Mucins*
;
Pediatrics
7.Primitive Neuroectodermal Tumor Arising from the Cerebellum: A Case Report.
Hack Gun BAE ; Kyeong Seok LEE ; Dong Suk HAN ; Il Gyu YUN ; In Soo LEE ; Seung Ha YANG
Journal of Korean Neurosurgical Society 1989;18(1):163-167
We report a 16-month-old male with a primitive neuroectodermal tumor of the cerebellar hemisphere. This tumor consisted of undifferentiated cells resembling germinal or matrix cells of the embryonic neural tube and prominent mesenchymal component.
Cerebellum*
;
Humans
;
Infant
;
Male
;
Neural Tube
;
Neuroectodermal Tumors, Primitive*
8.The Effect of Repeated Stress on the Modulation of Neuroactive Steroids at the GABAA-Benzodiazepine Receptor Complex in Rats.
Bong Suk JANG ; Jong Bum LEE ; Hyung Bae PARK ; Jung Hee HA ; Chang Jin SONG
Journal of Korean Neuropsychiatric Association 1999;38(3):656-663
OBJECTIVES: Pregnanolone is a potent positive modulator of the gamma-aminobutyric acid(GABA) response that enhances the binding of [3H]flunitrazepam to the GABA A receptor. Recently, it was reported that chronic treatment with pregnanolone uncouples allosteric interactions between steroid and benzodiazepine recognition sites. The present study was designed to assess the effect of repeated stress on the modulation of neuroactive steroids on the GABA A receptor. METHODS: The effect of steroids on the ligands binding to GABA A receptor was investigated using cerebral cortices of unstressed and repeatedly immobilized rats. Male Sprague-Dawley rats, weighing 200-250g were forced to suffer an immobilization stress for 2 hours. RESULTS: Pregnanolone enhanced the binding of [3H]flunitrazepam to GABA A receptor in both of unstressed and repeatedly stressed rats. However, repeatedly stressed rats showed significantly higher values in EC50 and lower values in E max of enhancement binding of [3H]flunitrazepam than those of unstressed rats. CONCLUSIONS: From these findings, it can be concluded that repeated stress reduced the positive modulation of neuroactive steroid on the GABA A-receptor complex.
Animals
;
Benzodiazepines
;
Cerebral Cortex
;
gamma-Aminobutyric Acid
;
Humans
;
Immobilization
;
Ligands
;
Male
;
Pregnanolone
;
Rats*
;
Rats, Sprague-Dawley
;
Receptors, GABA-A
;
Steroids*
9.The Performance of Serum Biomarkers for Predicting Fibrosis in Patients with Chronic Viral Hepatitis.
Chang Seok BANG ; Ha Yan KANG ; Gyu Ho CHOI ; Suk Bae KIM ; Wonae LEE ; Il Han SONG
The Korean Journal of Gastroenterology 2017;69(5):298-307
BACKGROUND/AIMS: The invasiveness of a liver biopsy and its inconsistent results have prompted efforts to develop noninvasive tools to evaluate the severity of chronic hepatitis. This study was intended to assess the performance of serum biomarkers for predicting liver fibrosis in patients with chronic viral hepatitis. METHODS: A total of 302 patients with chronic hepatitis B or C, who had undergone liver biopsy, were retrospectively enrolled. We investigated the diagnostic accuracy of several clinical factors for predicting advanced fibrosis (F≥3). RESULTS: The study population included 227 patients with chronic hepatitis B, 73 patients with chronic hepatitis C, and 2 patients with co-infection (hepatitis B and C). Histological cirrhosis was identified in 16.2% of the study population. The grade of porto-periportal activity was more correlated with the stage of chronic hepatitis compared with that of lobular activity (r=0.640 vs. r=0.171). Fibrosis stage was correlated with platelet count (r=-0.520), aspartate aminotransferase to platelet ratio index (APRI) (r=0.390), prothrombin time (r=0.376), and albumin (r=-0.357). For the diagnosis of advanced fibrosis, platelet count and APRI were the most predictive variables (AUROC=0.752, and 0.713, respectively). CONCLUSIONS: In a hepatitis B endemic region, platelet count and APRI could be considered as reliable non-invasive markers for predicting fibrosis of chronic viral hepatitis. However, it is necessary to validate the diagnostic accuracy of these markers in another population.
Aspartate Aminotransferases
;
Biomarkers*
;
Biopsy
;
Blood Platelets
;
Coinfection
;
Diagnosis
;
Fibrosis*
;
Hepatitis B
;
Hepatitis B, Chronic
;
Hepatitis C, Chronic
;
Hepatitis*
;
Hepatitis, Chronic
;
Humans
;
Liver
;
Liver Cirrhosis
;
Platelet Count
;
Prothrombin Time
;
Retrospective Studies
10.RT-PCR of Up-Regulated Factors in Abnormally Proliferated Vascular Endothelial Cells by 1,2- Dimethylhydrazine.
Sung Ho KIM ; Young Seok KANG ; Yong Chan BAE ; Suk Young PARK ; Su Bong NAM
Journal of the Korean Society of Plastic and Reconstructive Surgeons 2005;32(6):689-698
Many studies for verifying angiogenesis have been in progress, especially in the field of abnormal vascular proliferation to explain the pathogenesis and to develop a treatment of several diseases. In our previous experiments, endothelial cell proliferations were induced by DMH stimulation in vitro, and the 177 factors(142 up- regulated and 35 down-regulated factors) were identified. Among the up-regulated factors, 9 substances (EFEMP1, CTGF, CYR61, ITGbeta1, FHL2, SERPINE1, MYC, PTTG1 and MSH6) were selected, which were related to cell proliferation and showed high signal intensities. The RNA was isolated from HUVECs at the time of 0, 6, 12, 24 hours after the DMH treatment, and RNA of control group HUVECs was also isolated. Genetic information of selected molecules was used to make primer for each, and RT-PCR was performed to analyze both groups. In control and treatment groups, each substance presented variety of manifestation degree according to time differences. EFEMP1, CTGF, CYR61, ITGbeta1, FHL2 and MYC were related to abnormal vascular proliferation steadily and SERPINE1, PTTG1 and MSH6 were related secondarily. CTGF was related to both normal and abnormal proliferation, but it played a more significant role in abnormal proliferation from earlier stage. EFEMP1, CYR61, ITGbeta1, FHL2 and MYC were similar to CTGF, although the relation appeared lately. Further study should be performed to analyze the expressions and the interactions of growth factors, which could be utilized in the new therapeutic development.
Cell Proliferation
;
Dimenhydrinate
;
Dimethylhydrazines
;
Endothelial Cells*
;
Intercellular Signaling Peptides and Proteins
;
RNA
;
Umbilical Veins