Parvovirus B19 has been recently identified as the cause of various diseases such as erythema infectiosum, transient aplastic crisis in patients with chronic hemolytic anemias, hydrops fetalis, bone marrow suppression in immunocompromised hosts, and lastly acute and chronic arthropathy mimicking rheumatoid arthritis (RA) and occasionally, systemic lupus erythematosus (SLE). We describe a female patient who presented with fever, chills, polyarthralgia, serologic and PCR evidence of presence of Parvovirus B19, and expression of antinuclear antibody, anti- Ro/SSA and anti-La/SSB. There has been no clinical findings suggestive or diagnostic of any diffuse connective tissue diseases in this patient. Although there has been reports of Parvovirus B19 infection mimicking RA and SLE with manifestations of various autoimmune antibodies including rheumatoid factor, antinuclear antibody, anti-dsDNA, antilymphocyte antibody, and antiphospholipid antibody, there has not been any report of anti-Ro/SSA and anti-La/SSB expression in the setting of parvoviral arthropathy and this is the first case report.
Anemia, Hemolytic ; Antibodies ; Antibodies, Antinuclear* ; Antibodies, Antiphospholipid ; Antilymphocyte Serum ; Arthralgia ; Arthritis, Rheumatoid ; Bone Marrow ; Chills ; Connective Tissue Diseases ; Erythema Infectiosum ; Female ; Fever ; Humans ; Hydrops Fetalis ; Immunocompromised Host ; Lupus Erythematosus, Systemic ; Parvovirus* ; Polymerase Chain Reaction ; Rheumatoid Factor