The immune status in 26 typhoid fever patients has been studied. They are 15 males, 112 females from 16 to 30 years old. This study reveals that: during the fever period of the disease, pronounced disturbances in immune, homeostasis are observed, which are manifested by lymphopenia, with a considerable rise of natural killer (NK) and active rosette forming cells (Ea). At the period of convalescence, the parameters decreased to normal value, except a mild increase of immunoglobulin (IgM, IgG)
Typhoid Fever ; Autoimmunity

79 serum samples of tetanus patients admitted to The Institute for research on Clinical Medicine and Tropical Diseases from November 1996 to May 1997 were analysed by technique of inoculation in mice. The results showed that: 1) Free circulating tetanus toxin was detected in 19% of cases with 5.1% of cases with 5.1% of cases of low toxin concentration and 13.9% of cases of high toxin concentration. All them are negative after 5 days of ATS injection (Anti Tetanus Serum) with 6000-9000 IU (M.I). 2) The presence of free circulating tetanus toxin in the blood was not related to infectious condition of the wound (P>0.05). 3) Mortality in the group with positive free tetanus toxin (60%) are higher significantly (p<0.01) than the negative one (20.3%). So, free circulating tetanus toxin in the blood had a severe prognostic value in tetanus patients. 4) Using ATS was necessary for the treatment of tetanus patients. 5) Serum antitoxin concentration in most of tetanus patients (90%) was lower than the 'protective level' (<0.01IU/ml).
Tetanus ; Bood

79 sera of tetanus patients (Institute for Clinical Research in Tropical Diseases 1966, 1967, 1996 to 1997 were investigated for circulating toxin, using the mouse inoculation technique). Results: free circulating tetanus toxin was detected in 19,0% cases, among them 5,1% had low toxic concentration and 13,9% had high toxic concentration. The presence of free circulating tetanus toxin in the blood was not related to the infectious condition of the wound at admission. The mortality in the group with positive free circulating tetanus toxic was higher 60% than this in the negative one. So the presence of free circulating tetanus toxin in the blood had a prognostic value in tetanus patients. The use of tetanus antitoxin was necessary in the treatment of tetanus patients to neutralize free circulating tetanus toxin.
Tetanus ; Bood

54 patients with acute viral hepatitis of which hepatic coma (8), uncompensate cirrhosis (17) and liver cancer (14) participated to a study have shown that the serum gamma glutamyl transpeptidase ((-GT) activity was slightly increased in patients with viral hepatitis coma and uncompensate cirrhosis. This was a bad sign the (-GT was highly increased in patients with liver cancer. The average serum (-GT activity was increased about 3 times in the acute viral hepatitis. But diagnostic value of (-GT was lower than this of SGPT
Liver Diseases ; Serum ; gamma-Glutamyltransferase ; Hepatic Encephalopathy

54 patients with acute viral hepatitis (8 of those having hepatic coma), 17 patients with unrecovered cirrhosis and 14 patients with hepatoma who were admitted in Bach Mai Hospital form March 1996 to May 1997 were involved in this study. Results showed that serum -GT level is often normally or lightly increased in fulminant hepatic failure and in unrecovered cirrhosis. This suggests that monitoring serum -GT may help to prognosticate for patient with acute viral hepatitis of cirrhosis. Serum -GT activity increases in hepatoma, so the estimation of this enzyme may help to diagnose the disease. Serum -GT activity increases in acute viral hepatitis but is less significance than serum transaminase (SGPT) in diagnosing the disease.
Liver Diseases ; Serum ; gamma-Glutamyltransferase

A study on 73 patients including 27 patients with hepatitis A, 33 patients with hepatitis B and 13 patients with hepatitis C in the Institute of Clinical Medicine and Tropical Disease during 1990, 1993, 1994 has shown that most of patients with hepatitis were ages of under 40, especially under 30. The rate of hepatitis A was less than this hepatitis B; male patients were more than female patients. The common symptoms in stage before jaundice were fever, tired and anorexia. The common symptoms in stage of hepatitis jaundice were mucosal jaundice, anorexia and hepatomegaly, SGOT and SGPT were highly increased, and rate of proshombin in hepatitis B lower than this in hepatitis A and E, the blood total bilirubin in hepatitis B was highly increased.
Hepacivirus ; Hepatitis ; Lymphocytes

Study on 73 patients with acute viral hepatitis type A, B and E, almost patients with ages of less than 40 year old. The average age of patient with A type AVH (20.39.2 years) is less than that of patient with B type AVH (31.511.5 years) or E type AVH (20.9012.3 years). A, B, E type AVH occurred much more in male than in female. During preicteric phase, fever, fatigue, and loss appetite are symptoms that most patients with A, B, E type AVH complain of. Fever happens more frequently in A type AVH than in B type AVH. The duration of preicteric phase of E type AVH (4.22.4 days) is shorter than that of patients with A type AVH (6.75.5 days) or B type (7.66.3 days). Common symptoms observed in icteric phase of A, B, E type AVH are jaundice, loss of appetite and hepatomegaly. Clinical features and hepatic functional disorders of patient with B type AVH are more serious than that of patient with A and E type AVH.
Hepatitis ; Hepatomegaly

There are about 20 millions of people infected by dengue virus and 500 cases of haemorrhagic fever admitted to hospital every year in the world in which the mortality rate of the disease was 5%, even 15%. In Vietnam, the dengue fever and haemorrhagic dengue fever was an epidemic that its frequency of circulation was increasingly. During recent 5 years, the morbidity number and the mortality number of dengue fever/ haemorrhagic dengue fever were 10,8431 cases and 234 deaths, respectively. The diagnosis of the disease involved the viral isolation and serum diagnosis. The treatment involved the symptomatic management, close monitoring and timely management of shock
Dengue ; diagnosis ; therapeutics

Hepatitis B is common disease in the world. There were 350 millions persons who carry the chronic hepatitis B virus. The hepatitis B may cause the chronic hepatitis, cirrhosis and primary liver cancer. The hepatitis B virus transmitted mainly via blood and drug addiction. The virus also transmitted from mother to their children or by intercourse. The hepatitis B virus included 2 major types with the clinical and para-clinical features in 3 phases.
Hepatitis B ; Epidemiologic Methods

Background: Rotavirus vaccines used to prevent acute diarrhea among children under 5 years old. In Vietnam, with the assistance of the World Health Organization (WHO), Centers for disease control and prevention (CDC), Atlanta, United States, Ministry of Health and Ministry of science and technology researched to create rotavirus master seed G1P8 which would use to produce Rota virus in Vietnam. Objectives: to evaluate titre and safety of rotavirus master seed G1P8 in vitro and in experimental animals. Subjectives and Method: experimental studies in vitro and experimental animals. Rotavirus master seed G1P8 (KH0118) series 1 (MS-P5) and series 2 (MS-P5) produced in 2005, preserved 80oC, were determined by immunofluorescence method (with unit of FFU/ml). The strains were tested in experimental animal\u2019s safety like the safe requirements of World Health Organization on live-attenuated vaccine (OPV). Results: no detection for exotic virus strains in virus suspension by PCR and titres of rotavirus master seed were similar and were more than 107 FFU / ml. 10 intervened rabbits were healthy life during follow up period, 8/10 these rabbits increased weight after follow up period, only two rabbits reduced weight but increase of mean weight of all 10 rabbits was 106%. 5 intervened guinea-pig increased mean weight (158%) and healthy during follow-up period. 4 experimental white mice increased mean weight (195%), higher than control groups. It was safety in experimenting on baby mice. Conclusions: two lots of rotavirus master seed G1P8 produced in POLYVAC had high titre and safety both in vitro and in experimental animals.
Rotavirus ;