Defibrillator is the most important therapeutic for ventricular fibrillation.The preconditions for successful defibrillation include short defibrillated time,adoption of biphasic wave,appropriate electrode placement and shocked energy,as well as reasonable chest wall impedance.The defibrillation opportunity is the critical one of all factors for defibrillation.

To appraise the preventive and improvable effects of different movements on OA joints,animal models by fixing the left posterior knee joint in extention using plaster cast for 8 weeks in Newzealand rabbits were carried out. The rabbits were randomly divided into different groups, and the X-RAY、range of motion and ligament biomechanical features of the joint were observed.The results showed that proper movement improved the range of motion, restored tensile strength of the ligament around the OA joint.It is evident that movement improves the function of the OA joint and delays the OA exacerbation.The combination of active and passive movement is the best way to achieve good result.

Type-B RAF (BRAF) gene is one of the most popular genes of thyroid carcinoma in recent studies,and its mutation has significant relationships with the occurrence,development,treatment,and prognosis of papillary thyroid carcinoma(PTC).The influence of BRAFV600E mutation on the expression of iodine uptake relative proteins in PTC cells and the value of molecular targeted therapy with BRAFV600Einhibitors in the clinical treatment of PTC in the future were summarized in this review.

The biological threat is an important component of national security threats .Developed countries attach great importance to biodefense capability building .This paper analyzed the particularity of biological threats , explained the necessi-ty of biosecurity strategic research and development in China , and proposed establishing an integrated biodefense system .

OBJECTIVE:To evaluate the current situation of drug utilization in inpatients with schizophrenia in our hospital. METHODS:The medication of inpatients with schizophrenia during Nov. 2007～Nov.2008 were analyzed statistically,referring to the DDD and DUI method recommended by WHO. RESULTS:Quetiapine,olanzapine,risperidone dominated the first 3 place in DDDs,which were all atypical antipsychotic drugs. Sulpiride ranked at 17th place in the list of typical antipsychotic drugs. the DUI of most drugs were lower than 1.0. CONCLUSION:The medication of most patients with schizophrenia is appropriate. Atypical antipsychotic drugs occupy a dominant position in the clinic.

OBJECTIVE:To reduce and prevent the incidence of complaint events in outpatient dispensary.METHODS:The causes of patients' complaints were analyzed and the countermeasures were put forward.RESULTS & CONCLUSIONS:The complaint events mainly induced by the absence of rules and regulations for pharmacists,lack of related information and professional knowledge,unsoundness of internal management,patients' enhancement in self-protection consciousness as well medical knowledge.The countermeasures available include the following:strictly following rules and regulations and operating instruction,reinforcing legal consciousness and self-protection consciousness,shifting one's ideas and concepts,strengthen-ing service consciousness etc.

OBJECTIVE:To study the optimum conditions for extracting the effective components in Yansheng oral liquidMETHODS:Using orthogonal design L9(34),the content of total solid was taken as the screening indexInfluence of the concentration of alcohol on effective components was observedRESULTS:The number of times of extraction(D) had significant influence on the content of total solid(P

Protein kinase C pathway is an important intracellular signal transduction pathway.A growing number of evidences showes that activation of PKC influences endothelial cell permeability.In this review,we briefly summarize the effects and regulating pathways of protein kinase C in modulation of vascular endothelium permeability.

Islet transplantation is an effective method treating insulin-dependent diabetes mellitus, which is apt to supersede pancreas transplantation currently. Although human islet transplantation has already performed successfully, its long-term effect is still unsatisfying. Reasons causing loss of islet function is still not fully understood to date. Thus, deep research of factors influencing transplanted islet survival is of importance to improve long-term effect of islet transplantation. Patient selection and tissue matching, collection, preservation and transport of pancreatic organ, isolation and purification of islet cells, implement of islet transplantation, blood glucose control and immunosuppressive drug application during islet transplantation period, functional assessment after islet transplantation, etc. completion quality of each of these technical links is the factor influencing islet transplantation.

OBJECTIVE To investigate the antibiotic resistance and nosocomial infections status of Staphylococcus aureus (SAU) and provide scientific evidence for diseasis diagnose and reasonable use of antibiotics. METHODS A retrospective review was performed to analyze the clinical distribution of 321 isolates of SAU. Antibiotic susceptibility test was performed by K-B method and drug-resistance results were analyzed. RESULTS SAU was found been resistant to the diverse antibiotics in different degree. However, the drug sensitivity rate to glycopeptide antibiotics was 100.0%, as well as to new type antibiotic of linezolid. The isolating rate of meticillin-resistant S. aureus (MRSA) reached 57.6%. CONCLUSIONS S. aureus shows multidrug resistance to the commonly used antibiotics. We should strengthen monitoring and controlling of it.