Mizoribine,an immunosuppressive agent,plays a role in cell synthesis process,selectively inhibits lymphocyte proliferation,and suppresses immune function.It has obtained certain curative effect in resistance the rejection after kidney transplantation,slowing down lupus nephritis pathological progress,reducing the proteinuria and the risk of glomerular sclerosis on IgA nephropathy,decreasing the recurrence frequency and proteinuria on steroid-dependent nephrotic syndrome and reducing proteinuria level on Henoch-Schoenlein purpura nephritis.It's safer,fewer side effects,but for lacking evidences,large sample still be needed.

Bronchopulmonary corcinoma is one of the most common malignant tumors and the morbidity has been increased in recent years in China.The most effective treatment for non-small cell lung cancer is surgery assisted by radiotherapy and chemotherapy but still with unsatisfactory effect.In recent years,brachytherapy of iterstitial implantion of radioactive seeds is applied in the treatment of non-small cell lung cancer.Several methods have developed and a satisfactory local control rate has been found.Here is the review on the research progress of the implantation of radioactive particles treating non-small cell lung cancer.

Fragile histidine triad (FHIT) gene is an important tumor suppressor gene,in non-small-cell lung cancer and precancerous lesions its protein deficiency is common,reflecting the FHIT gene is changing in lung cancer occurred in the early molecular events.Ferredoxin in the participation of Fhit protein promotes the electron transport function,and promotes the apoptosis of tumour cells in oxidative stress environment.Fhit protein expression combined platinum enhanced the apoptosis of tumor cell response.With early occuring,high-frequency and facilitate detection,the abnormal changes of FHIT/FRA3B,which take great significance to explain the factors,such as race,genetic polymorphism,geography,environment,respiratory diseases in the pathogenesis of lung cancer.

Moyamoya disease is an uncommon chronic progressive occlusive cerebrovascular disease.It is mainly involved in the terminal internal carotid artery and the proximal portions of the anterior cerebral and middle cerebral arteries.Normally,there are differences between the conventional angiographic findings and the clinical manifestations and outcomes in moyamoya disease,while the perfusion imaging can provide important hemodynamic information.Currently,CT perfusion imaging and magnetic resonance perfusion imaging have been widely used in clinical practice.This article reviews the application of the two imaging techniques in moyamoya disease.

ASCT2 is a Na+-dependent neutral amino acid transporter in brush-border membrane of intestinal epithelial cells.The activity accounts for the majority of intestinal luminal neutral amino acid absorption,such as alanine,serine,cysteine,threonine,glutamine,asparagine and so on.The study about molecular and functional characteristics of ASCT2 will help to the understanding of bowel function,and offer the potential for developing new treatments for short bowel syndrome and other bowel dysfunction conditions.

Medical technology center can promot the development of the desciplines concerned.This paper discusses the feasibility and effect of multidisciplinary construction of medical technology center.We conclude that multidisciplinary participation is beneficial for the center,as these disciplines have respective strengths and are mutually complementary.

Objective To evaluate the efficacy of the drug-eluting stents in the treatment of coronary artery diseases in patients with diabetes. Methods This study included a retrospective database of 600 consecutive patients with coronary artery disease who underwent drug-eluting stems implantation in Zhong Shan Hospital,including 147 pa-tients with diabetes. The MACE in this study included death of any cause,nonfatal myocardial infarction,target lesion revascularization and target vessel revascularization. All the MACE were recorded. The efficacy of the drug-eluting stents was evaluated by the incidence of MACE and the rate of in-stent restenosis. Results No significant differences were found concerning the incidence of MACE (7. 9% vs 4. 9% ,P = 0. 344) as well as the rate of ISR(6. 0% vs 4.9% ,P =0. 540) between patients with diabetes and patients without diabetes. No significant differences were found concerning the incidence of MACE(7.9% vs 4. 9% ,P = 0. 344) as well as the rate of ISR( 1.4% vs 1.9% ,P = 1. 000) between Cypher stents and TAXUS stents. Conclusion Drug-eluting stents are effective in the treatment of coronary artery disease of patients with diabetes. There was no significant difference in the rate of MACE and in-stent restenosis between the two leading drug-eluting stents of sirolimus eluting Cypher stent and the paclitaxle eluting TAX-US stent.

Estrogen has the protective effect on cerebral ischemia in v ar ious ways. It not only can improve the regional cerebral blood flow during ische mia and rescue the remaining neurons alive, but also can reduce the injury of is chemia-reperfusion. In this article, we enumerate at the molecular level that e strogen has the properties of inhibiting the expression of VCAM and cytokines li ke TNF-? in the ischemia region, educing the overload of calcium and cytotoxic ity of EAA by modulating the calcium channels, and regulating related genes expr ession and anti-apoptosis. It is crucial for estrogen replacement therapy as a neutoprotectant clinically.

The effects of tetrandrine on the aggregation and morphological changes of platelets were studied by using the rabbit platelet-rich plasma prepared with centri-fugation.It was found that tetrandrine could markedly inhibit the platelet aggregation induced by ADP,collagen,and arachidonic acid with an IC50(50% inhibitory concentration) of 38.9,30.3 and 44.3?g/ml respectively.The platelets pretreated with tetrandrine could not be stimulated to initiate morphological changes and granule release,and their normal structures were well preserved.In addition,di-pyridamole could enhance but excessive amount of extracellular calcium could weaken the inhibition of tetrandrine on platelet aggregation.

Objective To explore the application effect of the model of clinical nursing path management in clinical nursing. Methods A comparative study was conducted of the clinical nursing paths respectively with regard to patients who had received thyroid adenoma resection and with regard to patients who had received hysteromyomectomy. Results In the experimental group involving clinical nursing path management, the average length of stay was shortened, pre operation days were reduced, and the average hospitalization expenses were lowered while the satisfaction rate of patients with thyroid adenoma rose by 2.18%, reaching 98.96% and that of patients with hysteromyoma rose by 2.87%, reaching 99.55%. At the same time, clinical nursing path management also enhanced the job satisfaction of nurses. Conclusion It is viable to adopt the model of clinical nursing path management in clinical nursing in China.