OBJECTIVE:To study the general regularity and characteristics of adverse drug reaction caused by meropenem,and to provide reference for rational use of drugs.METHODS:Vesicle and bullous change occurring in one patient with allergic dermatitis,age of 80,treated with meropenem were analyzed.Literatures about meropenem-induced ADR reported in domestic pharmaceutical journals from Jan.1994 to Dec.2009 were collected and analyzed statistically.RESULTS:Meropenem rarely caused ADR.The most clinical manifestations were diarrhea,rash and abnormality of liver function.CONCLUSION:Meropenem-induced ADR case is rare as well as allergic dermatitis.Great importance should be attached to meropenem-induced ADR.

Objective To explore the incidence of facial hormone-dependent dermatitis, and to raise the healing rate of it. Methods We applied non-steroid drug topically, cold compress combined with anti-histamine agents to treat facial hormone-dependent dermatitis in 68 cases. The results were compared before and after the treatment. Results There were significantly clinical effects of non-steroid drug topically, cold compress combined with antihistamine agents on facial hormone-dependent dermatitis, with healing rate of 82. 4 % , and effective rate of 100 %. Conclusions In order to reduce the incidence of facial hormone-dependent dermatitis, we should follow the principal of applying steroid agent strictly to treat facial dermatitis. Meanwhile, there is significantly clinical effects of non-steroid drug with topical use and cold compress combined with antihistamine agents on facial steroid-dependent dermatitis.

0.05).Comparison group model and normal control:detected the numbers of endothelial cells:①1 month:control group contrast with test group has no changed;②3 month:group 30Gy/N(P

Lens opacity attenuates the contrast sensitivity and clarity of eye due to scattering of light,which leads to poor vision in cataract patients.Phacoemulsification with primary intraocular lens is the primary surgical approach.Some complaints of vision discomfort commonly occur although the vision acuity is good.It is,therefore,vital for us to seek an objective evaluation system of visual quality after cataract surgery.Contrast sensitivity test and visual questionnaire offer valuable input for this issue.Contrast sensitivity can estimate vision function more accurately to better measure visual impairment preoperatively and vision outcome after cataract extraction.

Alcoholic liver disease (ALD) is one of the most common chronic liver diseases in clinical practice with a complicated pathogenesis.Genetic factors play an important role in the pathogenesis of ALD and might be the potential targets for the treatment of ALD.This article reviews the susceptibility genes associated with ALD in recent years and points out that the exploration of the mechanisms of action of these genes in the development and progression of ALD can provide a theoretical basis for effective evaluation,diagnosis,and prevention and treatment of ALD in clinical practice.

The proliferation,progression and metastasis of pancreatic cancer are complicated processes caused by muhiple factors.C-X-C motif ligand 5 (CXCL5) can recognize and bind to C-X-C motif receptor 2 (CXCR2),and activate or regulate the expression of signaling pathway by autocrine or paracrine pathway in cells.CXCL5/CXCR2 biological axis plays important roles in proliferation,adhesion,progression,metastasis and prognosis of pancreatic cancer,and is also associated with the angiogenesis and lymphangiogenesis of pancreatic cancer.So,direct or indirect regulation of CXCL5/CXCR2 expression in pancreatic cancer can be effective for target therapy of pancreatic cancer.

Objective To study the extent of psychological dysfunction and the relationship between the psychological dysfunction and age, personality as well as environment in patients with stutter by means of questionnaire.Methods 96 patients were asked to answer 60 questions before and after speech therapy about the following aspects: perception of reality; emotional stability; harmony of human relationship; psychological adaptability. Results The mean scores of the above four parts were 16.6, 129.5, 31.8 and 25.1 respectively before therapy. The mean scores were 8.9, 55.9, 19.1 and 14.6 respectively after therapy. The scores after therapy were less than those before therapy. Conclusion Serious psychological dysfunction was found in patients with stutter. After speech therapy a psychological dysfunction improved markedly .

Objective To evaluate the effect and mechanism of ginseng polysaccharides injective solu-tion on invasive ability of human breast cancer MCF-7 cells.Methods Human breast cancer MCF-7 cells were treated with different concentrations of ginseng polysaccharides injections(12.5μL/mL,25μL/mL,50μL/mL or 100μL/mL),and phosphate buffer saline was served as control.The invasive ability,transfer ability and protein expression of matrix metalloproteinases-2 ( MMP-2 ) and matrix metalloproteinases-9 ( MMP-9 ) were determined via transwell matrigel invasive test,scratch test and Western Blot,respectively.Results Ginseng pol-ysaccharide injection on invasive ability and transfer ability in vitro of MCF-7 cell had significant role in inhibi-ting effect,and showed dose and time dependent.After ginseng polysaccharides injection treatment,the MMP-2 and MMP-9 protein expression significantly reduced,and showed dose and time dependent manner.Conclusion Ginseng polysaccharides injection is able to inhibit the invasion and transfer in MCF -7 cells.Moreover,theregulation of MMP -2 and MMP -9 expression may be involved in this effect.

Evaluation of regional health service system can provide guidance for regional health planning,improve the ability of the national macro-control and supervision,and optimize the medical resource allocation.China has yet to establish a set of scientific and comprehensive evaluation index system.Through the introduction of the importance,influence factors and the current methods in evaluation of regional medical service system in US,suggestions are provided for establishing and improving China's evaluation system of regional health service.

Objective To investigate the serum levels of Thyroid stimulating hormone (TSH ) ,Thyroglobulin antibody (TgAb) and Peroxidase antibodies(TpoAb) in patients with different thyroid diseases and to explore the relationship between the 3 indexes with thyroid diseases .Methods 383 cases of thyroid diseases were divided into six groups ,simple adenoma of throid group(TA , n=30) ,nodular goiter group(NG ,n=59) ,papillary thyroid hyperplasia group(PTH ,n=36) ,nodular goiter with adenoma group (NG+ TA ,n=196) ,hashimoto′s thyroiditis(HT ,n=13) ,throid carcinoma group(TC ,n=49) .The relationship between concentra-tion of FT3 ,FT4 ,TSH ,TgAb ,TpoAb in serum and thyroid diseases incidence was analyzed .Results (1)The serum TSH concen-tration had statistically sinificance between group HT with group TA and NG ,group PTH and TA+NG group(P<0 .05) .Despite the concentration of serum TSH in TC group was in a high level near to the upper limit ,there was no statistically significance ver-sus other groups .(2)In group HT and TC ,the increased rate of TSH and positive rate of TgAb and TpoAb were significantly high-er than in group BT (P<0 .05) .(3)The double positive rate of TgAb and TpoAb ,the single positive rate of TpoAb in group HT and TC were higher than those in group BT (P<0 .05) .Conclusion There was a close correlation between serum TSH ,TgAb , TpoAb concentration and thyroid disease ,especially closely associated with HT and TC .Raised TSH and TpoAb positive have im-portant reference value in diagnosis of TC .