OBJECTIVE:To study the general regularity and characteristics of adverse drug reaction caused by meropenem,and to provide reference for rational use of drugs.METHODS:Vesicle and bullous change occurring in one patient with allergic dermatitis,age of 80,treated with meropenem were analyzed.Literatures about meropenem-induced ADR reported in domestic pharmaceutical journals from Jan.1994 to Dec.2009 were collected and analyzed statistically.RESULTS:Meropenem rarely caused ADR.The most clinical manifestations were diarrhea,rash and abnormality of liver function.CONCLUSION:Meropenem-induced ADR case is rare as well as allergic dermatitis.Great importance should be attached to meropenem-induced ADR.

0.05).Comparison group model and normal control:detected the numbers of endothelial cells:①1 month:control group contrast with test group has no changed;②3 month:group 30Gy/N(P

Objective To explore the incidence of facial hormone-dependent dermatitis, and to raise the healing rate of it. Methods We applied non-steroid drug topically, cold compress combined with anti-histamine agents to treat facial hormone-dependent dermatitis in 68 cases. The results were compared before and after the treatment. Results There were significantly clinical effects of non-steroid drug topically, cold compress combined with antihistamine agents on facial hormone-dependent dermatitis, with healing rate of 82. 4 % , and effective rate of 100 %. Conclusions In order to reduce the incidence of facial hormone-dependent dermatitis, we should follow the principal of applying steroid agent strictly to treat facial dermatitis. Meanwhile, there is significantly clinical effects of non-steroid drug with topical use and cold compress combined with antihistamine agents on facial steroid-dependent dermatitis.

Lens opacity attenuates the contrast sensitivity and clarity of eye due to scattering of light,which leads to poor vision in cataract patients.Phacoemulsification with primary intraocular lens is the primary surgical approach.Some complaints of vision discomfort commonly occur although the vision acuity is good.It is,therefore,vital for us to seek an objective evaluation system of visual quality after cataract surgery.Contrast sensitivity test and visual questionnaire offer valuable input for this issue.Contrast sensitivity can estimate vision function more accurately to better measure visual impairment preoperatively and vision outcome after cataract extraction.

Child ; China ; Emergency Medicine ; Humans ; Pediatrics

OBJECTIVE:To apply Markov model in the drug market and to discuss its effect on the forecasting of the dynamic state of drug market.METHOD:The principle of Markov model was expounded and its application in the forecasting of drug market was illustrated with examples.RESULT:Markov model was a forecasting method of many merits,which can be used to forecast those economy dynamic states that were in line with the condition of hypothesis.CONCLUSIONS:Markov model should be applied in drug market extensively.

OBJECTIVE: To improve the management level in outpatient dispensary.METHODS: The current management model in each outpatient dispensary of our hospital was introduced;the problems were pointed out and the proposals were put forward.RESULTS & CONCLUSIONS: The current outpatient pharmacy management mode and drug control measures of "individual responsibility,weekly small stocktaking,monthly big stocktaking,and irregular spot checks" is feasible,if optimized further,which would help enhance the working quality and service level in pharmacy.

Since the first launching of heart lung bypass machine in animal model in 1937,cardiopulmonary bypass(CPB) has become more and more consummate,but it still brings about many complications,including pulmonary,renal and hepatic dysfunctions.Among these complications,hepatic dysfunction plays an important role in the impairment after cardiac operations.The liver function indices such as aspartate aminotransferase,glutamate-pyruvate transaminase,bilirubin and alkaline phosphatase will step up obviously during 3 to 5 days after the operation.The physiological changes deteriorate patient's condition,and even influence the prognosis.This clinical phenomenon puzzles cardiac surgeons.All these demand us to answer the following questions: Is the cardiopulmonary bypass harm the liver? What's the mechanism? We review the different researches on hepatic injury after cardiopulmonary bypass.

The proliferation,progression and metastasis of pancreatic cancer are complicated processes caused by muhiple factors.C-X-C motif ligand 5 (CXCL5) can recognize and bind to C-X-C motif receptor 2 (CXCR2),and activate or regulate the expression of signaling pathway by autocrine or paracrine pathway in cells.CXCL5/CXCR2 biological axis plays important roles in proliferation,adhesion,progression,metastasis and prognosis of pancreatic cancer,and is also associated with the angiogenesis and lymphangiogenesis of pancreatic cancer.So,direct or indirect regulation of CXCL5/CXCR2 expression in pancreatic cancer can be effective for target therapy of pancreatic cancer.