From Jeunary 1986 to June 1991 107 cases of carcinoma of stomach were found by gastroscopy, in which 100cases were proved pathologically by biopsy (93.5%).The biopsy of other 7 cases was negative and the diagnosis was confirmed lately by operation.gastroscopy and pathological characteristics and their clinical significane were discussed (103 cases of carcinoma of stomach cases of early stage carcinoma ventriculi case of pinpoint carcinoma).The authors suggested that ulcer, erosion, nodule and stiff surface on the depressed mucosa at the antrum be examined carefully by means of gastroscopy and biopsy be done in order to discover early stage carcinoma ventriculi and make a correct diagnosis.Being aware of these features in not only beneficial to the reasonable clinical treatmet but also helpful to the diagnosis of carcinoma of stomach.

Objective:To study the mechanism of apoptosis in hippocampus of the rats with disorder of cortical developments.Methods:The Rats with disorder of cortical developments were established by carmustine(BUCN).AT P0,P15,P30,P45,P60,the number of apoptosis cell and expression of Bax and Bcl-2 in hippocampus were detected by TUNEL,immunohistochemistry method and RT-PCR;then the detected outcomes were analyzed by computer micrograph analysis system in control group and model group.Results:At P15,P30,P45,P60,the numbers of apoptosis,Bax,Bcl-2 masculine cell and bcl-2 MRNA,bax MRNA in hippocampus in the model group were more than those in the control group.The ratio of Bax/Bcl-2 in model group was significantly higher than those in the control group(P

Animals ; Antigens, Neoplasm ; genetics ; metabolism ; Biomarkers, Tumor ; genetics ; metabolism ; Brain Neoplasms ; metabolism ; Cell Adhesion Molecules ; genetics ; metabolism ; Digestive System Neoplasms ; metabolism ; Female ; Genital Neoplasms, Female ; metabolism ; Glioma ; metabolism ; Head and Neck Neoplasms ; metabolism ; Humans ; Immunotherapy ; Male ; Prostatic Neoplasms ; metabolism ; Signal Transduction

Pharmacodynamic (PD) studies play an important role in research and development of new traditonal Chinese medicines (TCMs). Phamacologic and toxicologic studies that aim to research drug ability can provide supporting data for the clinical trials and reduce the risk of clinical trials. In recent years, PD studies in TCMs are developing and progressing, but there are still some problems affecting the value of PD studies in the development of new TCMs. The value of PD studies depends on scientific and rational study design. This article summaries some defects in PD study design of new TCMs that are common in the application data, including defects in study type, testing targets, dosing, duration of administration, control group, testing time. This article also discusses some points of concern and specific requirements for PD study design of new TCMs.
Humans ; Medicine, Chinese Traditional ; methods ; Pharmacokinetics

Aim To observe the effects of heat shock protein 70 ( Hsp70 ) activator SW02 on lipopolysaccha-ride( LPS)-induced expression of inducible nitric oxide synthase ( iNOS ) and LPS-induced production of nitric oxide ( NO ) in macrophages. Methods RAW264. 7 cells were stimulated by LPS, and were divided into DMSO,DMSO+LPS(1 mg·L-1),SW02,and SW02+LPS ( 1 mg · L-1 ) groups. The protein expression was detected by Western blot. NO concentration was measured by Griess kit. The iNOS mRNA was detected by real-time PCR. The NF-κB binding to iNOS promot-ers was measured by chromatin immunoprecipitation ( ChIP ) assays. Results SW02 significantly blocked the protein and mRNA expression of iNOS as well as the production of NO in LPS-stimulated RAW264 . 7 cells(P<0. 01 or P<0. 05,SW02+LPS group vs DM-SO+LPS group) . SW02 did not affect the LPS-induced degradation of IκB-α( P>0. 05 , SW02 +LPS group vs DMSO+LPS group ) and nuclear translocation of NF-κB ( P > 0. 05 , SW02 + LPS group vs DMSO + LPS group) . However,SW02 reduced the NF-κB binding to iNOS promoters inside the cell( P<0. 05,SW02+LPS group vs DMSO+LPS group) . Conclusion These re-sults show that SW02 prevents iNOS expression and NO induction likely through attenuation of the NF-κB bind-ing to iNOS promoters in macrophages.

Objective To investigate the different gender and untreated hyperthyroidism parameter difference (hyperthyroidism) and hemoglobin of red blood cells in peripheral blood of patients with relatively healthy people.Methods Collecting blood samples of patients with hyperthyroidism,with EDTA-K2 anticoagulant,using Sysmex XE-2100 automated hematology analyzer analysis of peripheral blood hemoglobin in red blood cell parameters and using healthy people as healthy control.Results Healthy control group,male,female red blood cells and hemoglobin in patients with hyperthyroidism were increased,the difference was statistical-ly significant (P <0.05).Conclusion Newly diagnosed hyperthyroidism value and erythrocyte hemoglobin values higher than nor-mal.

Since the first launching of heart lung bypass machine in animal model in 1937,cardiopulmonary bypass(CPB) has become more and more consummate,but it still brings about many complications,including pulmonary,renal and hepatic dysfunctions.Among these complications,hepatic dysfunction plays an important role in the impairment after cardiac operations.The liver function indices such as aspartate aminotransferase,glutamate-pyruvate transaminase,bilirubin and alkaline phosphatase will step up obviously during 3 to 5 days after the operation.The physiological changes deteriorate patient's condition,and even influence the prognosis.This clinical phenomenon puzzles cardiac surgeons.All these demand us to answer the following questions: Is the cardiopulmonary bypass harm the liver? What's the mechanism? We review the different researches on hepatic injury after cardiopulmonary bypass.

OBJECTIVE:To explore the observation and nursing points of hemorrhage in intravenous thrombolysis after using alteplase. METHODS:128 patients underwent alteplase intravenous thrombolysis were selected as the research object. The occur-rence of hemorrhage in each part were observed within 48 hours after medication and nursed timely. RESULTS:128 patients re-ceived intravenous thrombolysis. 48 h later,26 patients suffered from hemorrhage complications (20.3%). Among them,there were 6 cases of nose bleeding (4.7%),8 cases of subcutaneous congestion (6.3%),6 cases of gingival bleeding (4.7%) and 6 cases of gastrointestinal bleeding(4.7%). There was no significant difference in the incidence of complications among those groups (P>0.05). The time of nose bleeding was (3.2 ± 1.3) h,the time of subcutaneous congestion (3.5 ± 1.2)h,the time of gingival bleeding(1.5±0.7)h,and the time of gastrointestinal bleeding(4.1±1.8)h. The time of gingival bleeding was earlier than that of other groups,with statistically significant difference(P<0.05). There was no statistically significant difference among other groups (P>0.05). CONCLUSIONS:In alteplase intravenous thrombolysis,nurses should closely monitor hemorrhage and complications, especially the complication of gingival bleeding. Find out the complications timely and nurse it as early as possible.

Three-dimensional (3D) reconstruction of medical images constructs the 3D models of organs using 2D medical image serials, which provide intuitionistic visual information for medical workers. However, most people concern about the CT images reconstruction, only few people focus on the reconstruction of Ultrasound images. In this thesis, it introduces Insight Segmentation and Registration Toolkit (ITK) and The Visualization Toolkit (VTK) firstly. Then it presents the process of Ultrasound image serials using ITK and VTK. At last, it presents the outcome of the experiment. The results show that the reconstruction of Ultrasound images can also get good effect by using ITK and VTK.

The imaging appearance of progressive multifocal leukoencephalopathy (PML) in acquired immunodeficiency syndrome (AIDS), including CT and MRI appearance, the differential diagnosis between PML and other similarly diseases were reviewed.