Purpose:To evaluate the efficacy of NP regimen (NVB and DDP) in advanced non-small-cell lung cancer (NSCLC). Methods:48 patients with advanced NSCLC were treated by NP regimen. All of them had stage Ⅲ-Ⅳ disease (22 of them were primary treatment, the others were subsequent treatment). The chemotherapy dosage of NVB was 25 mg/m2 iv. d1,5, That of DDP was 35 mg/m2 iv d1,3.Results:The overall response rate (RR) was 50%, medium response time 5.5 months, medium survival time 11 months. The RR of 22 patients with primary treatment was 63.6%. The other patients after multiple course therapy 38.5%. The major adverse effects were myelosuppression and vein inflammation drug infusion through deep vein could avoid the vein inflammation. Conclusions:Authors suggest that NP regimen is effective therapy for non-small-cell lung cancer and deserves further clinical observation.

Purpose:To investigate clinical effects and side reactions of advanced NSCLC by combined chemotherapy base on gemcitabine. Methods:36 cases of advanced NSCLC were divided into two groups: Group 1, 20 cases were treated by gemcitabine 1.6 g at d1,d8,d15 and 80mg/m 2 DDP at d1; Group 2,16 cases were treaded by gemcitabine 1.6 g and paclitaxel 60 mg at d1,d8,d15.Both groups were repeated every 4 weeks and clinical effects were evaluated after 3 cycles.Results:CR 1 case, PR 17 cases, SD 16 cases, PD 2 cases and CR+PR 18 cases (response rate 50 0%) in 36 cases observed. In 20 cases primary treatments:CR+PR 11cases (response rate 55 0%);In 16 cases re-treatments: CR+ PR 7 cases (response rate 43.75%); In 15 cases of advanced NSCLC re-treated by gemcitabine combined with paclitaxel: CR+PR 7 cases (response rate 46.7%). Side reaction: most cases showed bone marrow suppression and symptoms of gastrointestinal side-effects, which included 12 cases of Ⅲ-Ⅳ grades leukocytopenia (33.3%),7 cases of Ⅱ-Ⅲ grades soterocytopenia (19.4%),8 cases of Ⅲ-Ⅳ grades symptoms of gastrointestinal side-effects (22.2%),2 cases of Ⅱ grades abnormal liver function.Conclusions:Better clinical effects have been achieved in the therapy of advanced NSCLC by combined methods based on gemcitabine and side-reactions are tolerable;Nice effects were obtained in the re-treatment of NSCLC by gemcitabine combined with paclitaxel.It is valuable to investigate its Clinical effects more deeply.

Nuclear receptor transcription factors are ligand-activated proteins that control various biological events from cell growth and development to lipid metabolism, and energy and glucose homeostasis. Nuclear receptors are important drug targets for metabolic diseases. Liver X receptors (LXRs) are nuclear receptor transcription factors that play essential roles in regulation of cholesterol, triglyceride, fatty acid, and glucose homeostasis. LXR-deficient mice have shown the association of LXR-signaling pathway dysfunction with several human pathologies including atherosclerosis, hyperlipidemia, Alzheimer's disease and cancer. Thus, LXRs are promising pharmacological targets for these diseases. Synthetic LXR agonists may lower cholesterol, but increase triglyceride and induce fatty liver. The naturally occurring LXR ligands, with moderate activity, may serve as nutraceuticals for prevention or treatment of the disorders, while minimizing potential side effects. In this review, recent advances in natural LXR modulators are summarized including agonist, antagonist and the modulator of LXR pathway.

In order to to be a outstanding doctor must have the six elements:theory, practice, moral quality, psychological quality, developing quality and communication quality. To cultivate outstanding physicians are de-signed, on the ability of accommodation;A sound personality and good professional ethics;Unity, is the ability to obtain from the following several aspects:reform the traditional education teaching system, establishing the special general education management organization, set up a scientific system of general education courses, makes the strong ability of general education teachers and building with students as the core of teaching methods.

Purpose To investigate the MRI findings and to improve the understanding of spinal epidural angiolipomas. Materials and Methods MRI findings were retrospectively analyzed in two cases of surgery and pathology proven spinal epidural angiolipomas. Relevant literatures were reviewed. Results Two cases of spinal epidural angiolipomas were located in the lumber and lower thoracic spinal canal. The tumors were elongated or spindle in shape within the epidural space, and parallel to the longitudinal axis. In both cases part of the tumors were hyperintense on T1WI and T2WI, attenuated on fat-saturated sequences with mild enhancement. Some areas were hypointenseon T1WI, hyperintenseon T2WI, unattenuated on fat-saturated sequences with apparent enhancement. Angiolipomas were classified according to the MRI features. One was type I and the other was type III. Both cases were non-infiltrative. Conclusion MRI shows the size, shape, MRI signals and the association with the adjacent structure of spinal epidural angiolipomas. The MRI classification is helpful for improving the understanding of the tumor. MRI is the best imaging modality to diagnose spinal epidural angiolipomas.

Objective: To establish a method for the determination of ketoconazole and miconazole nitrate in compound ketocon-azole gels. Methods:An HPLC method was developed. A Hypersil BDS C18 column(416 mm × 200 mm,5μm) was used, the mobile phases consisted of 0. 5% ammonium acetate solution-methanol(containing 0. 2% triethanolamine) (20∶80), the flow rate was 1. 0 ml ·min-1 , the detection wavelength was set at 230nm, the column temperature was 30℃ and the injection volume was 20μl. Results:There was a good linear correlation within the range of 5. 1-510. 0 mg·L-1 for ketoconazole (r=0. 999 9) and 50. 0-500. 0 mg·L-1 for miconazole nitrate (r=0. 999 9), the average recovery for ketoconazole and miconazole nitrate was 100. 3%(RSD=0. 38%, n=6) and 99. 9%(RSD=0. 79%, n=6), respectively. Conclusion:The method is simple, rapid, accurate and sensitive, and can pro-vide a method for controlling the quality of compound ketoconazole gels.

During the treatment of pediatric tumor,vincristine is one of the most widely used and most effective drugs. However,the adverse reactions have limited its clinical application. In recent years,studies have found that the metabolism of vincristine are different in different races and different individuals,and co-ad-ministration with certain drugs such as imidazoles antifungal drugs may enhance its adverse reaction. Resear-ches on new drug delivery system provide a new idea for reducing the adverse reactions of vincristine and impro-ving its bioavailability.

Construction of knowledge service system for university students'innovation and undertaking training program was proposed by analyzing their difficulties in information access during innovation and undertaking train-ing.The key points in constructing knowledge service system were pointed out, namely establishing professional service teams, providing stereoscopic and diversified service, establishing feedback and evaluation systems, and building powerful platform for information exchange.

The prevalence of childhood primary hypertension is increasing each year,not only bring-ing symptoms to these children,but also causing damage to multiple target organs such as heart,kidney,blood vessels,eyes and nerve system. Childhood hypertension is a risk factor of adult hypertension. Paying atten-tion to and preventing childhood hypertension has become a public health challenge. There are many associat-ed risk factors for childhood primary hypertension,including parental hypertension,overweight and obesity, low birth weight,and so forth. From the analysis of these factors,suggestions can be given about how to pre-vent childhood primary hypertension.

Objective To compare the effect and safety of totally transumbilical single -port laparoscopic herniorrhaphy and traditional surgery in treatment with pediatric indirect inguinal hernia.Methods 100 children with indirect inguinal hernia were divided into control group(n =50)and observation group(n =50).The control group was given to traditional surgery.The observation group was given to totally transumbilical single -port laparoscopic herniorrhaphy.The operation related index,postoperative complications and hernia recurrence rate were compared between the two groups.Results The intraoperatve bleeding,incision length,operation time and hospital stays of the observation group respectively were (18.1 ±5.9)mL,(1.3 ±0.3)cm,(27.4 ±7.9)min and (4.5 ±1.2)d,those of the control group respectively were (38.7 ±8.1)mL,(2.2 ±0.4)cm,(46.7 ±9.2)min and (7.4 ±1.3)d,the difference was statistically significant (t =3.439,3.811,2.872,2.878,P =0.026,0.019,0.045,0.049).The postoperative complications rate of observation the group and the control group were respectively 8.0%(4 /50)and 24.0%(12 /50),the difference was statistically significant(χ2 =4.762,P =0.029).Postoperative follow -up of 1 year,the hernia recurrence rate of the observation group and the control group respectively was 0(0 /50)and 12%(6 /50),the difference was statistically significant (χ2 =6.383,P =0.012).Conclusion Using totally transumbili-cal single -port laparoscopic herniorrhaphy treat with pediatric indirect inguinal hernia is safe and effective.It is ben-eficial to prevent recurrence,and is worth clinical promotion.