The management of patients with cancer of unknown primary site (CUP) is a notoriously medical problem. The outcome is bad in most patients. The clinical general characteristics, histopathology, im-aging features and endoscopies can provide some useful information, and the primary site can be detected in part of these patients, but most are not. With the application of molecular biology and positron emission tomography-computed tomography(PET-CT) technology, the detection rate of CUP has increased significantly.

BACKGROUND: Numerous studies have shown that Danshen Root can suppress adhesion and aggregation of neutrophils as well as production of oxygen free radical, can activate blood circulation to dissipate blood stasis. However, there are few studies about precise mechanisms underlying protection of vascular endothelium and anti-thrombosis, especially concerning the mechanism of action following coronary artery stent implantation.OBJECTIVE: To investigate the influence of Danhong injection on vascular endothelial function before and after coronary artery stent implantation in patients with acute coronary syndrome (ACS). METHODS: A total of 60 ACS patients were randomly assigned to two groups. The patients in the conventional treatment group were subjected to conventional drug treatment following coronary artery stent implantation. The patients in the Danhong injection group received conventional drug treatment and Danhong injection (20 mL/d) following coronary artery stent implantation. The treatment course was 10 days. Before and after implantation as well as before and after Danhong injection treatment, endothelium-derived blood flow-mediated vasodilation, plasma endothelin, thromboxane B2, 6-keto-prostaglandin levels were determined, and the vascular endothelial function were evaluated. Simultaneously, short-term prognosis was observed in patients of both groups.RESULTS AND CONCLUSION: Plasma endothelin and thromboxane B2 levels were significantly increased, but 6-keto-prostaglandin levels were significantly decreased following stent implantation in patients of both groups compared with that before implantation (P < 0.05). Plasma endothelin and thromboxane B2 levels were significantly reduced, but endothelium-derived blood flow-mediated vasodilation and 6-keto-prostaglandin levels were significantly increased in both groups following treatment compared with that following implantation (P < 0.05, P < 0.01), especially in the Danhong injection group (P < 0.05). During hospitalization, the incidences of cardiovascular events were diminished in the Danhong injection group compared with conventional drug treatment group (P > 0.05). Results suggested that Danhong injection significantly improves vascular endothelial function, induces vasodilatation, improves blood supply, inhibits platelet aggragation, and shows the tendency of ameliorating short-term prognosis.

DBJECTIVE: To evaluate the efficacy of traditional Chinese medicine in the treatment of complications following cerebrovascular stent placement.METHODS: A computer screen was performed for Science Direct database and Ei database between January 1960 and October2009,using key words of"traditional Chinese medicine,stent placement,complication",and the language was limited to English.At the same time,Chinese Journal Full-text database and Chinese Biomedical Literature database between January 1994 and October 2009 were searched for related articles,using key words of"traditional Chinese medicine,cerebral blood vessels,stent placement,complications",and the language was limited to Chinese.In addition,several monographs were manually consulted.The basic and clinical trials addressing the prevention and treatment of traditional Chinese medicine on the complications following cerebrovascular stenting were included.RESULTS: Subsequent to the cerebrovascular stent placement,the traditional Chinese medicine interventions include benefiting Qi,invigorating blood circulation,and eliminating phlegm,which all serve as the basic approach,in addition these interventions are accompanied by relieving Qi and stagnancy in liver,soothing the nerves and benefiting water,cooling blood and stopping bleeding.The commonly used traditional Chinese medicine compound is consisted of Shengmai San,Buyang Huanwu decoction,Xuefu Zhuyu decoction,sini decoction and resist decoction.Modern pharmacological studies have shown that a large number of traditional Chinese medicine and compound which are always used to benefit Qi,invigorate blood circulation,dissipate blood stasis and eliminate phlegm,can effectively prevent the complications following cerebrovascular stent placement through a multi-component,multi-target,multi-channel integration regulatory role.CONCLUSION: The traditional Chinese medicine interventions during the peri-operative period of cerebral vascular stent placement exhibit a feature of Chinese medicine and play an important role for improving the success rate of surgery,preventing and reducting peri-operative period and long-term complications.

Objective To explore clinical curative effect of lamivudine in treatment of HBV reactivation.Methods The clinical data of HBV reactivation patients in immunosuppressive therapy were retrospectively analyzed. Results The clinical symptom and liver function recovery rate, HBV-DNA darkening rate, HBeAg darkening rate and HBe-Ag/anti HBe frequence of seroconversion of detection group were higher than that of control group,the difference was statistically significant( all P ＜ 0. 05 ). Conclusion The clinical curative effect of HBV reactivation in immunosuppressive therapy by Lamivudine was good.

Child ; Diagnostic Errors ; Epilepsy ; diagnosis ; Female ; Humans ; Pseudohypoparathyroidism ; diagnosis

A new method of calculating fractal dimension of short-term heart rate variability signals is presented. The method is based on wavelet transform and filter banks. The implementation of the method is: First of all we pick-up the fractal component from HRV signals using wavelet transform. Next, we estimate the power spectrum distribution of fractal component using auto-regressive model, and we estimate parameter 7 using the least square method. Finally according to formula D = 2- (gamma-1)/2 estimate fractal dimension of HRV signal. To validate the stability and reliability of the proposed method, using fractional brown movement simulate 24 fractal signals that fractal value is 1.6 to validate, the result shows that the method has stability and reliability.
Algorithms ; Electrocardiography ; Fourier Analysis ; Fractals ; Heart Rate ; physiology ; Humans ; Least-Squares Analysis ; Nonlinear Dynamics ; Signal Processing, Computer-Assisted

Objective To investigate the ontogeny of the islet amyloid polypeptide(IAPP)and explore the relationship IAPP and other classical hormones in human fetal colon and rectum. Methods The localization of IAPP immunoreactive(IR) cells and 5 hydroxytryptamine(5 HT) IR cells in 31 human fetal colon and rectum from 9\|27 weeks of gestation was investigated with immunohistochemical SABC method. Results At 9 weeks of fetal age,a lot of 5 HT IR cells were found in the colon,but IAPP IR cells appeared at 18 weeks.In the rectum,both 5 HT and IAPP IR cells were present at 11 weeks,the number of 5 HT IR cells ascended gradually with fetus aged,reached a peak at 20 weeks and dropped gradually after 21 weeks,while in the whole fetus period,IAPP IR cells appeared fewer and scattered.The co localization of IAPP and 5 HT in some cells of colon and rectum was proved as compared with adjacent sections.Immunohistochemical double staining procedures on the same tissue section also showed that IAPP co existed with 5 HT in some cells.Conclusion\ During the human fetus,IAPP were synthesized and co existed with 5 HT in endocrine cells of the colon and rectum.The possible function on the co existence of IAPP and 5 HT in the colon and rectum of fetal was discussed. [

Silk fiber,as a kind of natural polymer,has been used as surgical sutures in clinic for years.Silk fiber is composed of a filament core protein,termed fibroin and a glue-like coating called sericin proteins.Due to its unique mechanical properties,good biocompatibility and slow degradability,silk fiber has been put in variety of applications as a new kind of biomedical scaffolds in recent years.With the development of the processing technique,silk fiber can be processed through the new versatile processing method to form various forms of scaffolds and its surface could be modified for different purposes.Further more,it could be tailored through genetic recombination to form the silk fibroin-like polymers which has a promising potential in medical applications.

[Summary] The incidences of obesity and its associated diseases are increasing worldwide.Bariatric surgery leads to more sustainable weight loss and better glycemic control compared with conservative medical treatment. Potential mechanisms mediating the improvement in glycemic control after bariatric surgery include changes in the levels of food intake, gastrointestinal hormones, bile acids as well as intestinal bacterial flora.

The objective of this article was to deliberate the relationship between trace elements and "Qi and blood" theory of traditional Chinese medicine by studying the similarities and differences in the contents of trace elements in SiJunzi decoction and Siwu decoction. Experiments indicate that there were some similarities and differences in the contents of trace elements in SiJunzi decoction and Siwu decoction, and it is very similar to "Qi and blood" theory of traditional Chinese medicine. When the Chinese herbs were decocted, the trace elements of Chinese herbs do not get into medicated solution uniformly. Different elements enter into the medicated solution in different periods of time and batches. It point out that the theory of methods of decocting Chinese herbs has a certain basis. These experiments remain existing some questions and doubts,it is worth to do some further related experiments and to be researched furthe.